{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:53:14Z","timestamp":1763628794313,"version":"3.45.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Netw Model Anal Health Inform Bioinforma"],"DOI":"10.1007\/s13721-025-00654-7","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:50:33Z","timestamp":1763628633000},"update-policy":"https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Target identification and mechanism elucidation of Chai Hu Shu Gan-San against the comorbidity of insomnia and depression based on integrative computational pharmacology"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/linproxy.fan.workers.dev:443\/https\/orcid.org\/0000-0002-3634-0053","authenticated-orcid":false,"given":"Meesala Krishna","family":"Murthy","sequence":"first","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"654_CR1","doi-asserted-by":"publisher","first-page":"D789","DOI":"10.1093\/nar\/gku1205","volume":"43","author":"JS Amberger","year":"2014","unstructured":"Amberger JS, Bocchini CA, Schiettecatte F, Scott AF, Hamosh A (2014) OMIM.org: online Mendelian inheritance in man (OMIM\u00ae), an online catalog of human genes and genetic disorders. Nucleic Acids Res 43:D789\u2013D798. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gku1205","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"654_CR2","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1192\/bjp.bp.111.106666","volume":"202","author":"RES Anglin","year":"2013","unstructured":"Anglin RE, Samaan Z, Walter SD, McDonald SD (2013) Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry 202(2):100\u2013107. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1192\/bjp.bp.111.106666","journal-title":"Br J Psychiatry"},{"issue":"1","key":"654_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.36877\/pddbs.a0000424","volume":"6","author":"PF Ayodele","year":"2023","unstructured":"Ayodele PF, Bamigbade A, Bamigbade OO, Adeniyi IA, Tachin ES, Seweje AJ, Farohunbi ST (2023) Illustrated procedure to perform molecular docking using pyrx and biovia discovery studio visualizer: a case study of 10kt with Atropine. Prog Drug Discov Biomed Sci 6(1):1\u201331. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.36877\/pddbs.a0000424","journal-title":"Prog Drug Discov Biomed Sci"},{"issue":"1\u20133","key":"654_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jad.2011.01.011","volume":"135","author":"C Baglioni","year":"2011","unstructured":"Baglioni C, Battagliese G, Feige B, Spiegelhalder K, Nissen C, Voderholzer U, Lombardo C, Riemann D (2011) Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord 135(1\u20133):10\u201319. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.jad.2011.01.011","journal-title":"J Affect Disord"},{"issue":"9","key":"654_CR5","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1037\/bul0000053","volume":"142","author":"C Baglioni","year":"2016","unstructured":"Baglioni C, Nanovska S, Regen W, Spiegelhalder K, Feige B, Nissen C, Reynolds III CF, Riemann D (2016) Sleep and mental disorders: a meta-analysis of polysomnographic research. Psychol Bull 142(9):969\u2013990. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1037\/bul0000053","journal-title":"Psychol Bull"},{"issue":"W1","key":"654_CR6","doi-asserted-by":"publisher","first-page":"W257","DOI":"10.1093\/nar\/gky318","volume":"46","author":"P Banerjee","year":"2018","unstructured":"Banerjee P, Eckert AO, Schrey AK, Preissner R (2018) Protox-II: a webserver for the prediction of toxicity of chemicals. Nucleic Acids Res 46(W1):W257\u2013W263. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gky318","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"654_CR7","doi-asserted-by":"publisher","first-page":"W513","DOI":"10.1093\/nar\/gkae303","volume":"52","author":"P Banerjee","year":"2024","unstructured":"Banerjee P, Kemmler E, Dunkel M, Preissner R (2024) Protox 3.0: a webserver for the prediction of toxicity of chemicals. Nucleic Acids Res 52(W1):W513\u2013W520. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkae303","journal-title":"Nucleic Acids Res"},{"key":"654_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2023.101174","volume":"37","author":"MA Basar","year":"2023","unstructured":"Basar MA, Hosen MF, Kumar Paul B, Hasan MR, Shamim SM, Bhuyian T (2023) Identification of drug and protein-protein interaction network among stress and depression: a bioinformatics approach. Inf Med Unlocked 37:101174. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.imu.2023.101174","journal-title":"Inf Med Unlocked"},{"issue":"2","key":"654_CR9","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.3892\/mmr.2016.5382","volume":"14","author":"GP Cao","year":"2016","unstructured":"Cao GP, Gui D, Fu LD, Guo ZK, Fu WJ (2016) Anxiolytic and neuroprotective effects of the traditional Chinese medicinal formulation Dan-zhi-xiao-yao-san in a rat model of chronic stress. Mol Med Rep 14(2):1247\u20131254. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.3892\/mmr.2016.5382","journal-title":"Mol Med Rep"},{"issue":"2","key":"654_CR11","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.pharmthera.2011.01.014","volume":"130","author":"L Capuron","year":"2011","unstructured":"Capuron L, Miller AH (2011) Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 130(2):226\u2013238. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.pharmthera.2011.01.014","journal-title":"Pharmacol Ther"},{"issue":"9","key":"654_CR12","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1176\/appi.ajp.2018.17121383","volume":"175","author":"A Caspi","year":"2018","unstructured":"Caspi A, Moffitt TE (2018) All for one and one for all: mental disorders in one dimension. Am J Psychiatry 175(9):831\u2013844. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1176\/appi.ajp.2018.17121383","journal-title":"Am J Psychiatry"},{"issue":"S4","key":"654_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-8-s4-s11","volume":"8","author":"CH Chin","year":"2014","unstructured":"Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY (2014) CytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol 8(S4):S11. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1186\/1752-0509-8-s4-s11","journal-title":"BMC Syst Biol"},{"issue":"2","key":"654_CR14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.9758\/cpn.23.1093","volume":"22","author":"J Chung","year":"2023","unstructured":"Chung J, Kim YC, Jeong JH (2023) Bipolar disorder, circadian rhythm and clock genes. Clin Psychopharmacol Neurosci 22(2):211\u2013221. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.9758\/cpn.23.1093","journal-title":"Clin Psychopharmacol Neurosci"},{"issue":"1","key":"654_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-024-01179-2","volume":"7","author":"A Daina","year":"2024","unstructured":"Daina A, Zoete V (2024) Testing the predictive power of reverse screening to infer drug targets, with the help of machine learning. Commun Chem 7(1):105. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1038\/s42004-024-01179-2","journal-title":"Commun Chem"},{"issue":"1","key":"654_CR16","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7(1):42717. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1038\/srep42717","journal-title":"Sci Rep"},{"issue":"W1","key":"654_CR17","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina A, Michielin O, Zoete V (2019) Swisstargetprediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res 47(W1):W357\u2013W364. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkz382","journal-title":"Nucleic Acids Res"},{"key":"654_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.32948\/ajpt.2024.07.22","volume":"4","author":"S Dhinesh Kumar","year":"2024","unstructured":"Dhinesh Kumar S, Rajasekaran A, Kumar KS (2024) Insilico toxicity prediction by using ProTox-II computational tools. Asia-Pacific J Pharmacotherapy Toxicol 4:41\u201346. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.32948\/ajpt.2024.07.22","journal-title":"Asia-Pacific J Pharmacotherapy Toxicol"},{"issue":"1","key":"654_CR19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad031","volume":"39","author":"M Franz","year":"2023","unstructured":"Franz M, Lopes CT, Fong D, Kucera M, Cheung M, Siper MC, Huck G, Dong Y, Sumer O, Bader GD (2023) Cytoscape.js 2023 update: a graph theory library for visualization and analysis. Bioinformatics 39(1):btad031. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/bioinformatics\/btad031","journal-title":"Bioinformatics"},{"issue":"W1","key":"654_CR20","doi-asserted-by":"publisher","first-page":"W726","DOI":"10.1093\/nar\/gkac297","volume":"50","author":"K Gallo","year":"2022","unstructured":"Gallo K, Goede A, Preissner R, Gohlke BO (2022) SuperPred 3.0: drug classification and target prediction-a machine learning approach. Nucleic Acids Res 50(W1):W726\u2013W731. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkac297","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"654_CR21","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","volume":"36","author":"SX Ge","year":"2019","unstructured":"Ge SX, Jung D, Yao R (2019) Shinygo: a graphical gene-set enrichment tool for animals and plants. Bioinformatics 36(8):2628\u20132629. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/bioinformatics\/btz931","journal-title":"Bioinformatics"},{"issue":"23","key":"654_CR22","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1093\/bioinformatics\/btt540","volume":"29","author":"D Gfeller","year":"2013","unstructured":"Gfeller D, Michielin O, Zoete V (2013) Shaping the interaction landscape of bioactive molecules. Bioinformatics 29(23):3073\u20133079. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/bioinformatics\/btt540","journal-title":"Bioinformatics"},{"issue":"5","key":"654_CR23","first-page":"499","volume":"43","author":"J Heitzman","year":"2009","unstructured":"Heitzman J (2009) Sleep disturbances-cause or result of depression. Psychiatr Pol 43(5):499\u2013511","journal-title":"Psychiatr Pol"},{"issue":"11","key":"654_CR24","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"AL Hopkins","year":"2008","unstructured":"Hopkins AL (2008) Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4(11):682\u2013690. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1038\/nchembio.118","journal-title":"Nat Chem Biol"},{"key":"654_CR25","doi-asserted-by":"publisher","unstructured":"Hosen MF, Basar MA, Yasmin MF, Morshed M, Uddin MS (2024) Identification of key signaling pathways and novel computational drug target for depression and coronary artery disease. IEEE Int Conf Comput Appl Syst (COMPAS), Cox\u2019s Bazar, Bangladesh, pp 1\u20134. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1109\/compas60761.2024.10796501","DOI":"10.1109\/compas60761.2024.10796501"},{"issue":"Suppl 2","key":"654_CR26","doi-asserted-by":"publisher","first-page":"W169","DOI":"10.1093\/nar\/gkm415","volume":"35","author":"DW Huang","year":"2007","unstructured":"Huang DW, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC, Lempicki RA (2007) DAVID bioinformatics resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res 35(Suppl 2):W169\u2013W175. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkm415","journal-title":"Nucleic Acids Res"},{"key":"654_CR71","doi-asserted-by":"publisher","unstructured":"Huang MW, Yang HJ, Zhou XC, Ge FX, Jiao SG, Tu PF, Xie YY, Chai XY (2019) Advances on network pharmacology in ethnomedicine research. Zhongguo Zhong Yao Za Zhi\u2009=\u2009Zhongguo Zhongyao Zazhi\u2009=\u2009China. J Chin Materia Med 44(15):3187\u20133194. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.19540\/j.cnki.cjcmm.20190711.201","DOI":"10.19540\/j.cnki.cjcmm.20190711.201"},{"issue":"1","key":"654_CR27","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/npp.2016.148","volume":"42","author":"MR Irwin","year":"2016","unstructured":"Irwin MR, Opp MR (2016) Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology 42(1):129\u2013155. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1038\/npp.2016.148","journal-title":"Neuropsychopharmacology"},{"key":"654_CR28","doi-asserted-by":"publisher","unstructured":"Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/28.1.27","DOI":"10.1093\/nar\/28.1.27"},{"key":"654_CR29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr988","author":"M Kanehisa","year":"2012","unstructured":"Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M (2012) KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res 40:D109\u2013D114. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkr988"},{"issue":"D1","key":"654_CR30","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","volume":"45","author":"M Kanehisa","year":"2016","unstructured":"Kanehisa M, Furumichi M, Tanabe M, Sato Y, Morishima K (2016) KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res 45(D1):D353\u2013D361. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkw1092","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"654_CR31","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2024","unstructured":"Kanehisa M, Furumichi M, Sato Y, Matsuura Y, Ishiguro-Watanabe M (2024) KEGG: biological systems database as a model of the real world. Nucleic Acids Res 53(D1):D672\u2013D677. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkae909","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"654_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-025-04892-0","volume":"25","author":"X Kang","year":"2025","unstructured":"Kang X, Wang T, Wan H, Fu W, Lin S (2025) Xiao yao san mitigates corticosterone stimulation-induced hippocampal neuronal damage by inhibiting GR phosphorylation and nuclear translocation via FKBP4 involvement. BMC Complement Med Ther 25(1):155. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1186\/s12906-025-04892-0","journal-title":"BMC Complement Med Ther"},{"issue":"21","key":"654_CR33","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.1111\/febs.13412","volume":"282","author":"J Keaney","year":"2015","unstructured":"Keaney J, Campbell M (2015) The dynamic blood-brain barrier. FEBS J 282(21):4067\u20134079. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1111\/febs.13412","journal-title":"FEBS J"},{"issue":"D1","key":"654_CR34","doi-asserted-by":"publisher","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","volume":"49","author":"S Kim","year":"2020","unstructured":"Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE (2020) PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res 49(D1):D1388\u2013D1395. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkaa971","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"654_CR35","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/prot.20151","volume":"56","author":"JA Kovacs","year":"2004","unstructured":"Kovacs JA, Chac\u00f3n P, Abagyan R (2004) Predictions of protein flexibility: first-order measures. Proteins Struct Funct Bioinform 56(4):661\u2013668. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1002\/prot.20151","journal-title":"Proteins Struct Funct Bioinform"},{"key":"654_CR36","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/978-1-4615-0323-1_8","volume-title":"Cytokines and mental Health. Neurobiological foundation of aberrant behaviors","author":"JM Krueger","year":"2003","unstructured":"Krueger JM, Churchill L (2003) Cytokines and sleep regulation. In: Kronfol Z (ed) Cytokines and mental Health. Neurobiological foundation of aberrant behaviors, vol 7. Springer, Boston, MA, pp 147\u2013165. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1007\/978-1-4615-0323-1_8"},{"issue":"6","key":"654_CR37","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.apsb.2019.10.001","volume":"9","author":"Y Li","year":"2019","unstructured":"Li Y, Meng Q, Yang M, Liu D, Hou X, Tang L, Wang X, Lyu Y, Chen X, Liu K, Yu AM, Zuo Z, Bi H (2019) Current trends in drug metabolism and pharmacokinetics. Acta Pharm Sin B 9(6):1113\u20131144. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.apsb.2019.10.001","journal-title":"Acta Pharm Sin B"},{"issue":"7","key":"654_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-12553-y","volume":"15","author":"XY Li","year":"2025","unstructured":"Li XY, Li K, Wei YH, Yu WK, Wu JH, Gao K, He WJ, Niu PP, Zhang C, Cheng YN, Li YS (2025a) Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation. Sci Rep 15(7):26365. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1038\/s41598-025-12553-y","journal-title":"Sci Rep"},{"key":"654_CR39","doi-asserted-by":"publisher","unstructured":"Li W, Wang Q, Dang C, Xiong Y, Lu Y (2025b) Chinese herbal medicine for insomnia: A systematic review and network meta-analysis. Medicine 104(33):e43789. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1097\/MD.0000000000043789","DOI":"10.1097\/MD.0000000000043789"},{"issue":"13","key":"654_CR40","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.2174\/0109298673299665240924090617","volume":"32","author":"CT Lin","year":"2025","unstructured":"Lin CT, Lin HY, Peng WH, Wu LY (2025) Multi-target mechanisms of Si-Ni-San on anxious insomnia: an example of network-pharmacology and molecular docking analysis. Curr Med Chem 32(13):2640\u20132663. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.2174\/0109298673299665240924090617","journal-title":"Curr Med Chem"},{"key":"654_CR41","doi-asserted-by":"publisher","first-page":"D198","DOI":"10.1093\/nar\/gkl999","volume":"35","author":"T Liu","year":"2006","unstructured":"Liu T, Lin Y, Wen X, Jorissen RN, Gilson MK (2006) BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Nucleic Acids Res 35:D198\u2013D201. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkl999","journal-title":"Nucleic Acids Res"},{"issue":"22","key":"654_CR42","doi-asserted-by":"publisher","first-page":"8523","DOI":"10.26355\/eurrev_202211_30388","volume":"26","author":"XX Liu","year":"2022","unstructured":"Liu XX, Ma YQ, Wang YG, Zhong FX, Yin XP, Zhang QM (2022) Suanzaoren decoction for the treatment of chronic insomnia: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci 26(22):8523\u20138533. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.26355\/eurrev_202211_30388","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"20","key":"654_CR43","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1093\/bioinformatics\/btr497","volume":"27","author":"JR Lop\u00e9z-Blanco","year":"2011","unstructured":"Lop\u00e9z-Blanco JR, Garz\u00f3n JI, Chac\u00f3n P (2011) Imod: multipurpose normal mode analysis in internal coordinates. Bioinformatics 27(20):2843\u20132850. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/bioinformatics\/btr497","journal-title":"Bioinformatics"},{"key":"654_CR44","doi-asserted-by":"publisher","first-page":"W271","DOI":"10.1093\/nar\/gku339","volume":"42","author":"JR L\u00f3pez-Blanco","year":"2014","unstructured":"L\u00f3pez-Blanco JR, Aliaga JI, Quintana-Ort\u00ed ES, Chac\u00f3n P (2014) iMODS: internal coordinates normal mode analysis server. Nucleic Acids Res 42:W271\u2013W276. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gku339","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"654_CR45","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s11655-019-3064-0","volume":"26","author":"TT Luo","year":"2019","unstructured":"Luo TT, Lu Y, Yan SK, Xiao X, Rong XL, Guo J (2019) Network pharmacology in research of Chinese medicine formula: methodology, application and prospective. Chin J Integr Med 26(1):72\u201380. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1007\/s11655-019-3064-0","journal-title":"Chin J Integr Med"},{"issue":"7","key":"654_CR46","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/nn.2139","volume":"11","author":"M Lutter","year":"2008","unstructured":"Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky SA, Anderson JG, Jung S, Birnbaum S, Yanagisawa M, Elmquist JK, Nestler EJ, Zigman JM (2008) The orexigenic hormone Ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 11(7):752\u2013753. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1038\/nn.2139","journal-title":"Nat Neurosci"},{"key":"654_CR47","doi-asserted-by":"publisher","unstructured":"Ma T, Sun Y, Jiang C, Xiong W, Yan T, Wu B, Jia Y (2021) A combined network Pharmacology and molecular Docking approach to investigate candidate active components and multitarget mechanisms of hemerocallis flowers on antidepressant effect. Evidence-Based Complement Altern Medicine: ECAM 2021(6):7127129. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1155\/2021\/7127129","DOI":"10.1155\/2021\/7127129"},{"issue":"1","key":"654_CR48","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nri.2015.5","volume":"16","author":"AH Miller","year":"2015","unstructured":"Miller AH, Raison CL (2015) The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 16(1):22\u201334. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1038\/nri.2015.5","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"654_CR49","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1002\/pro.3781","volume":"29","author":"BHM Mooers","year":"2019","unstructured":"Mooers BHM (2019) Shortcuts for faster image creation in PyMOL. Protein Sci 29(1):268\u2013276. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1002\/pro.3781","journal-title":"Protein Sci"},{"issue":"16","key":"654_CR50","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30(16):2785\u20132791. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1002\/jcc.21256","journal-title":"J Comput Chem"},{"issue":"1","key":"654_CR51","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jsmc.2014.11.009","volume":"10","author":"M Murphy","year":"2014","unstructured":"Murphy M, Peterson MJ (2014) Sleep disturbances in depression. Sleep Med Clin 10(1):17. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.jsmc.2014.11.009","journal-title":"Sleep Med Clin"},{"issue":"6","key":"654_CR52","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1017\/s1461145707008401","volume":"11","author":"F Ng","year":"2008","unstructured":"Ng F, Berk M, Dean O, Bush AI (2008) Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 11(6):851\u2013876. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1017\/s1461145707008401","journal-title":"Int J Neuropsychopharmacol"},{"key":"654_CR53","doi-asserted-by":"publisher","first-page":"W26","DOI":"10.1093\/nar\/gku477","volume":"42","author":"J Nickel","year":"2014","unstructured":"Nickel J, Gohlke BO, Erehman J, Banerjee P, Rong WW, Goede A, Dunkel M, Preissner R (2014) Superpred: update on drug classification and target prediction. Nucleic Acids Res 42:W26\u2013W31. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gku477","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"654_CR54","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cell.2013.03.034","volume":"153","author":"R Nussinov","year":"2013","unstructured":"Nussinov R, Tsai CJ (2013) Allostery in disease and in drug discovery. Cell 153(2):293\u2013305. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.cell.2013.03.034","journal-title":"Cell"},{"key":"654_CR66","doi-asserted-by":"publisher","unstructured":"Pan Z, Li M, Jin Z, Sun D, Zhang D, Hu B, Li Z, Jing Y, Sun S (2022) Research status of Chinese medicine formula based on network pharmacology. Pharmacol Res Mod Chin Med 4:100132. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.prmcm.2022.100132","DOI":"10.1016\/j.prmcm.2022.100132"},{"issue":"D1","key":"654_CR55","doi-asserted-by":"publisher","first-page":"D845","DOI":"10.1093\/nar\/gkz1021","volume":"48","author":"J Pi\u00f1ero","year":"2019","unstructured":"Pi\u00f1ero J, Ram\u00edrez-Anguita JM, Sa\u00fcch-Pitarch J, Ronzano F, Centeno E, Sanz F, Furlong LI (2019) The disgenet knowledge platform for disease genomics: 2019 update. Nucleic Acids Res 48(D1):D845\u2013D855. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkz1021","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"654_CR56","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","volume":"58","author":"DEV Pires","year":"2015","unstructured":"Pires DEV, Blundell TL, Ascher DB (2015) PkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. J Med Chem 58(9):4066\u20134072. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1021\/acs.jmedchem.5b00104","journal-title":"J Med Chem"},{"issue":"10","key":"654_CR57","doi-asserted-by":"publisher","first-page":"420","DOI":"10.6026\/97320630001420","volume":"1","author":"M Pirooznia","year":"2007","unstructured":"Pirooznia M, Nagarajan V, Deng Y (2007) Genevenn - a web application for comparing gene lists using venn diagrams. Bioinformation 1(10):420\u2013422. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.6026\/97320630001420","journal-title":"Bioinformation"},{"issue":"1","key":"654_CR58","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41386-019-0411-y","volume":"45","author":"D Riemann","year":"2019","unstructured":"Riemann D, Krone LB, Wulff K, Nissen C (2019) Sleep, insomnia, and depression. Neuropsychopharmacology 45(1):74\u201389. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1038\/s41386-019-0411-y","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"654_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"J Ru","year":"2014","unstructured":"Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, Xu X, Li Y, Wang Y, Yang L (2014) TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform 6(1):13. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1186\/1758-2946-6-13","journal-title":"J Cheminform"},{"key":"654_CR10","unstructured":"Rui S, Jiping F, Tao L, Xindong C, Jie Z, Zhenyun H, Yan M (2019) Jiawei xiaoyao capsule treatment for mild to moderate major depression with anxiety symptoms: a randomized, double-blind, double-dummy, controlled, multicenter, parallel-treatment trial. J Tradit Chin Med 39(3):410\u2013417"},{"issue":"5","key":"654_CR60","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1176\/ajp.122.5.509","volume":"122","author":"JJ Schildkraut","year":"1965","unstructured":"Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122(5):509\u2013522. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1176\/ajp.122.5.509","journal-title":"Am J Psychiatry"},{"issue":"11","key":"654_CR61","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"key":"654_CR62","doi-asserted-by":"publisher","unstructured":"Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y, Kaplan S, Dahary D, Warshawsky D, Golan YG, Kohn A, Rappaport N, Safran M, Lancet D (2016) The genecards suite: from gene data mining to disease genome sequence analyses. Curr Protocols Bioinf 54(1). https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1002\/cpbi.5","DOI":"10.1002\/cpbi.5"},{"issue":"D1","key":"654_CR63","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2020","unstructured":"Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, Doncheva NT, Legeay M, Fang T, Bork P, Jensen LJ, von Mering C (2020) The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res 49(D1):D605\u2013D612. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkaa1074","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"654_CR64","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.joim.2022.07.003","volume":"20","author":"KR Tang","year":"2022","unstructured":"Tang KR, Mo XW, Zhou XY, Chen YY, Liu DD, He LL, Ma QY, Li XJ, Chen JX (2022) Xiaoyao san, a Chinese herbal formula, ameliorates depression-like behavior in mice through the AdipoR1\/AMPK\/ACC pathway in hypothalamus. J Integr Med 20(5):442\u2013452. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.joim.2022.07.003","journal-title":"J Integr Med"},{"key":"654_CR73","doi-asserted-by":"publisher","unstructured":"The UniProt Consortium (2024) UniProt: the universal protein knowledgebase in 2025. Nucleic Acids Res 53(D1):D609\u2013D617. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1093\/nar\/gkae1010","DOI":"10.1093\/nar\/gkae1010"},{"issue":"2","key":"654_CR65","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2009","unstructured":"Trott O, Olson AJ (2009) Autodock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31(2):455\u2013461. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1002\/jcc.21334","journal-title":"J Comput Chem"},{"key":"654_CR67","unstructured":"Wikipedia (2005) Guipi Wan. In Pharmacopoeia of The People\u2019s Republic of China (Volume I). Chemical Industry Press. https:\/\/linproxy.fan.workers.dev:443\/https\/en.wikipedia.org\/wiki\/Guipi_Wan"},{"key":"654_CR68","doi-asserted-by":"publisher","unstructured":"Wu H, Yale W, Shumei C, Guiyun L, Donggui L, Xianming W (2023) Hei-Xiao-Yao-San improves amyloid plague in alzheimer\u2019s disease mice by regulating the PERK\/CHOP pathway. Wiley.\u00a0 https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.22541\/au.168638224.47337521\/v1","DOI":"10.22541\/au.168638224.47337521\/v1"},{"issue":"2","key":"654_CR69","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.chmed.2022.12.007","volume":"15","author":"J Xie","year":"2023","unstructured":"Xie J, Xu D, Wang C, Huang J (2023) Jiawei Xiaoyao san in treatment of anxiety disorder and anxiety: a review. Chin Herb Med 15(2):214\u2013221. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1016\/j.chmed.2022.12.007","journal-title":"Chin Herb Med"},{"key":"654_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13020-018-0183-z","volume":"13","author":"R Yan","year":"2018","unstructured":"Yan R, Yang Y, Chen Y (2018) Pharmacokinetics of Chinese medicines: strategies and perspectives. Chin Med 13:1\u201312. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1186\/s13020-018-0183-z","journal-title":"Chin Med"},{"issue":"33","key":"654_CR72","doi-asserted-by":"publisher","first-page":"8276","DOI":"10.1021\/acs.jpcb.6b01991","volume":"120","author":"XQ Yao","year":"2016","unstructured":"Yao XQ, Skj\u00e6rven L, Grant BJ (2016) Rapid characterization of allosteric networks with ensemble normal mode analysis. J Phys Chem B 120(33):8276\u20138288. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1021\/acs.jpcb.6b01991","journal-title":"J Phys Chem B"},{"issue":"S6","key":"654_CR74","doi-asserted-by":"publisher","first-page":"278","DOI":"10.36468\/pharmaceutical-sciences.spl.809","volume":"85","author":"W Zeng","year":"2023","unstructured":"Zeng W, Jiang J, Wu F (2023) Study on the synergistic effect of Chaihu Shugan San and Liuzijue in treating depression: traditional Chinese medicine formula. Indian J Pharm Sci 85(S6):278\u2013283. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.36468\/pharmaceutical-sciences.spl.809","journal-title":"Indian J Pharm Sci"},{"issue":"1","key":"654_CR75","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-024-01056-z","volume":"20","author":"Y Zhai","year":"2025","unstructured":"Zhai Y, Liu L, Zhang F, Chen X, Wang H, Zhou J, Chai K, Liu J, Lei H, Lu P, Guo M, Guo J, Wu J (2025) Network pharmacology: a crucial approach in traditional Chinese medicine research. Chin Med 20(1):8. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1186\/s13020-024-01056-z","journal-title":"Chin Med"},{"key":"654_CR76","doi-asserted-by":"publisher","unstructured":"Zhang Z (2020) Cardiovascular disease treatment from perspective of traditional Chinese medicine combined with evidence-based medicine. In: AIP Conference Proceedings 2252(1): 020024. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1063\/5.0020712","DOI":"10.1063\/5.0020712"},{"issue":"492470","key":"654_CR77","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fphar.2019.00123","volume":"10","author":"R Zhang","year":"2019","unstructured":"Zhang R, Zhu X, Bai H, Ning K (2019) Network pharmacology databases for traditional Chinese medicine: review and assessment. Front Pharmacol 10(492470):123. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.3389\/fphar.2019.00123","journal-title":"Front Pharmacol"},{"issue":"1","key":"654_CR78","doi-asserted-by":"publisher","DOI":"10.26420\/austinpharmacolpharm.2023.1026","volume":"7","author":"J Zhang","year":"2023","unstructured":"Zhang J, Chen Z, Gao F, Fan Y, Huang X, Zhou W (2023) Systems pharmacology-based research on the mechanism of Danzhi Xiaoyao San in the treatment of depression. Austin Pharmacol Pharm 7(1):1026. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.26420\/austinpharmacolpharm.2023.1026","journal-title":"Austin Pharmacol Pharm"},{"issue":"Suppl 11","key":"654_CR79","doi-asserted-by":"publisher","first-page":"791097","DOI":"10.3389\/fphar.2021.791097","volume":"12","author":"X Zhu","year":"2022","unstructured":"Zhu X, Li T, Hu E, Duan L, Zhang C, Wang Y, Tang T, Yang Z, Fan R (2022) Proteomics study reveals the anti-depressive mechanisms and the compatibility advantage of Chaihu-Shugan-San in a rat model of chronic unpredictable mild stress. Front Pharmacol 12(Suppl 11):791097. https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.3389\/fphar.2021.791097","journal-title":"Front Pharmacol"}],"container-title":["Network Modeling Analysis in Health Informatics and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/link.springer.com\/content\/pdf\/10.1007\/s13721-025-00654-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/link.springer.com\/article\/10.1007\/s13721-025-00654-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/link.springer.com\/content\/pdf\/10.1007\/s13721-025-00654-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:50:38Z","timestamp":1763628638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/link.springer.com\/10.1007\/s13721-025-00654-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":79,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["654"],"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.1007\/s13721-025-00654-7","relation":{"references":[{"id-type":"doi","id":"10.1093\/nar\/gkr988","asserted-by":"subject"}]},"ISSN":["2192-6670"],"issn-type":[{"value":"2192-6670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"25 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Author declares no competing of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not Applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not Applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"156"}}