{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:34:41Z","timestamp":1769114081925,"version":"3.49.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZR2021MF098"],"award-info":[{"award-number":["ZR2021MF098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172248"],"award-info":[{"award-number":["62172248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prediction of drug\u2013drug interactions (DDIs) is essential for the development and repositioning of new drugs. Meanwhile, they play a vital role in the fields of biopharmaceuticals, disease diagnosis and pharmacological treatment. This article proposes a new method called DBGRU-SE for predicting DDIs. Firstly, FP3 fingerprints, MACCS fingerprints, Pubchem fingerprints and 1D and 2D molecular descriptors are used to extract the feature information of the drugs. Secondly, Group Lasso is used to remove redundant features. Then, SMOTE-ENN is applied to balance the data to obtain the best feature vectors. Finally, the best feature vectors are fed into the classifier combining BiGRU and squeeze-and-excitation (SE) attention mechanisms to predict DDIs. After applying five-fold cross-validation, The ACC values of DBGRU-SE model on the two datasets are 97.51 and 94.98%, and the AUC are 99.60 and 98.85%, respectively. The results showed that DBGRU-SE had good predictive performance for drug\u2013drug interactions.<\/jats:p>","DOI":"10.1093\/bib\/bbad184","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T20:51:20Z","timestamp":1684961480000},"source":"Crossref","is-referenced-by-count":16,"title":["DBGRU-SE: predicting drug\u2013drug interactions based on double BiGRU and squeeze-and-excitation attention mechanism"],"prefix":"10.1093","volume":"24","author":[{"given":"Mingxiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Qingdao University of Science and Technology , China"}]},{"given":"Hongli","family":"Gao","sequence":"additional","affiliation":[{"name":"Qingdao University of Science and Technology , China"}]},{"given":"Xin","family":"Liao","sequence":"additional","affiliation":[{"name":"Qingdao University of Science and Technology , China"}]},{"given":"Baoxing","family":"Ning","sequence":"additional","affiliation":[{"name":"Qingdao University 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