{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:47:57Z","timestamp":1753876077936,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":144,"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108014 82171396"],"award-info":[{"award-number":["81820108014 82171396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108014 82171396"],"award-info":[{"award-number":["81820108014 82171396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system. \u2018Omics\u2019 technologies (genomics, transcriptomics, proteomics) and associated drug information have begun reshaping our understanding of multiple sclerosis. However, these data are scattered across numerous references, making them challenging to fully utilize. We manually mined and compiled these data within the Multiple Sclerosis Gene Database (MSGD) database, intending to continue updating it in the future. We screened 5485 publications and constructed the current version of MSGD. MSGD comprises 6255 entries, including 3274 variant entries, 1175 RNA entries, 418 protein entries, 313 knockout entries, 612 drug entries and 463 high-throughput entries. Each entry contains detailed information, such as species, disease type, detailed gene descriptions (such as official gene symbols), and original references. MSGD is freely accessible and provides a user-friendly web interface. Users can easily search for genes of interest, view their expression patterns and detailed information, manage gene sets and submit new MS-gene associations through the platform. The primary principle behind MSGD\u2019s design is to provide an exploratory platform, aiming to minimize filtration and interpretation barriers while ensuring highly accessible presentation of data. This initiative is expected to significantly assist researchers in deciphering gene mechanisms and improving the prevention, diagnosis and treatment of MS.<\/jats:p>\n               <jats:p>Database URL: https:\/\/linproxy.fan.workers.dev:443\/http\/bio-bigdata.hrbmu.edu.cn\/MSGD<\/jats:p>","DOI":"10.1093\/database\/baae037","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T20:34:38Z","timestamp":1716582878000},"source":"Crossref","is-referenced-by-count":0,"title":["MSGD: a manually curated database of genomic, transcriptomic, proteomic and drug information for multiple sclerosis"],"prefix":"10.1093","volume":"2024","author":[{"given":"Tao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , No.45 Changchun Street, Xicheng District, Beijing 100053, China"},{"name":"National Center for Neurological Disorders , No.45 Changchun Street, Xicheng District, Beijing 100053, China"}]},{"given":"Yaopan","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Guanghao","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Jingyan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Shanshan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Fanfan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Yuling","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Yifangfei","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Huixue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Xiaotong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Yuze","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , No.1 Shuaifuyuan, Dongcheng District, Beijing 100730, China"}]},{"ORCID":"https:\/\/linproxy.fan.workers.dev:443\/https\/orcid.org\/0000-0003-4079-8945","authenticated-orcid":false,"given":"Shangwei","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Lihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China"}]},{"given":"Junwei","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , No.45 Changchun Street, Xicheng District, Beijing 100053, China"},{"name":"National Center for Neurological Disorders , No.45 Changchun Street, Xicheng District, Beijing 100053, China"}]}],"member":"286","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"2024062912221640600_R1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler."},{"key":"2024062912221640600_R2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2016.187","article-title":"Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis","volume":"13","author":"Olsson","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"2024062912221640600_R3","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","article-title":"Multiple sclerosis","volume":"391","author":"Thompson","year":"2018","journal-title":"Lancet"},{"key":"2024062912221640600_R4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"2024062912221640600_R5","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.cell.2023.03.008","article-title":"Multiple sclerosis: neuroimmune crosstalk and therapeutic targeting","volume":"186","author":"Charabati","year":"2023","journal-title":"Cell"},{"key":"2024062912221640600_R6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/brain\/119.2.449","article-title":"Age-adjusted recurrence risks for relatives of patients with multiple sclerosis","volume":"119","author":"Robertson","year":"1996","journal-title":"Brain"},{"key":"2024062912221640600_R7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/brain\/awt356","article-title":"Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden","volume":"137","author":"Westerlind","year":"2014","journal-title":"Brain"},{"key":"2024062912221640600_R8","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.tig.2017.09.004","article-title":"The genetics of multiple sclerosis: from 0 to 200 in 50 years","volume":"33","author":"Baranzini","year":"2017","journal-title":"Trends Genet."},{"key":"2024062912221640600_R9","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1177\/1352458511402411","article-title":"Relevance of IL7R genotype and mRNA expression in Dutch patients with multiple sclerosis","volume":"17","author":"Sombekke","year":"2011","journal-title":"Mult. 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Neurosci."},{"key":"2024062912221640600_R13","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/iji.12197","article-title":"Age- and gender-specific effects on VDR gene polymorphisms and risk of the development of multiple sclerosis in Tunisians: a preliminary study","volume":"42","author":"Ben-Selma","year":"2015","journal-title":"Int. J. Immunogenet."},{"key":"2024062912221640600_R14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2478\/bjmg-2022-0003","article-title":"Vitamin D receptor polymorphisms among the Turkish population are associated with multiple sclerosis","volume":"25","author":"Bulan","year":"2022","journal-title":"Balk. J. Med. Genet."},{"key":"2024062912221640600_R15","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/427519","article-title":"Positive association of vitamin D receptor gene variations with multiple sclerosis in South East Iranian population","volume":"2015","author":"Narooie-Nejad","year":"2015","journal-title":"Biomed Res. Int."},{"key":"2024062912221640600_R16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/FPC.0000000000000420","article-title":"Association between polymorphisms in the vitamin D receptor and susceptibility to multiple sclerosis","volume":"31","author":"Cancela Diez","year":"2021","journal-title":"Pharmacogenet. Genom."},{"key":"2024062912221640600_R17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/19338244.2014.937381","article-title":"Heavy metals, organic solvents, and multiple sclerosis: an exploratory look at gene-environment interactions","volume":"71","author":"Napier","year":"2016","journal-title":"Arch. Environ. Occup. Health"},{"key":"2024062912221640600_R18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-5728(96)00182-8","article-title":"TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients","volume":"72","author":"Huizinga","year":"1997","journal-title":"J. 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