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Although lncRNA\u2013disease associations have received significant attention, no online repository is available to collect lncRNA-mediated regulatory mechanisms, key downstream targets, and important biological functions driven by disease-related lncRNAs in human diseases. We thus developed LncTarD (https:\/\/linproxy.fan.workers.dev:443\/http\/biocc.hrbmu.edu.cn\/LncTarD\/ or https:\/\/linproxy.fan.workers.dev:443\/http\/bio-bigdata.hrbmu.edu.cn\/LncTarD), a manually-curated database that provides a comprehensive resource of key lncRNA\u2013target regulations, lncRNA-influenced functions, and lncRNA-mediated regulatory mechanisms in human diseases. LncTarD offers (i) 2822 key lncRNA\u2013target regulations involving 475 lncRNAs and 1039 targets associated with 177 human diseases; (ii) 1613 experimentally-supported functional regulations and 1209 expression associations in human diseases; (iii) important biological functions driven by disease-related lncRNAs in human diseases; (iv) lncRNA\u2013target regulations responsible for drug resistance or sensitivity in human diseases and (v) lncRNA microarray, lncRNA sequence data and transcriptome data of an 11 373 pan-cancer patient cohort from TCGA to help characterize the functional dynamics of these lncRNA\u2013target regulations. LncTarD also provides a user-friendly interface to conveniently browse, search, and download data. LncTarD will be a useful resource platform for the further understanding of functions and molecular mechanisms of lncRNA deregulation in human disease, which will help to identify novel and sensitive biomarkers and therapeutic targets.<\/jats:p>","DOI":"10.1093\/nar\/gkz985","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T22:19:30Z","timestamp":1571264370000},"source":"Crossref","is-referenced-by-count":31,"title":["LncTarD: a manually-curated database of experimentally-supported functional lncRNA\u2013target regulations in human diseases"],"prefix":"10.1093","author":[{"given":"Hongying","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Jian","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Yunpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Aimin","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Caiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Junjie","family":"Lei","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Haotian","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Zhijun","family":"Leng","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Tengyue","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Waidong","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Shihua","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Yun","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"},{"name":"College of Bioinformatics, Hainan Medical University, Haikou 570100, China"}]}],"member":"286","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"2019111206183678100_B1","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/ijc.31865","article-title":"Systematic identification of lincRNA-based prognostic biomarkers by integrating lincRNA expression and copy number variation in lung adenocarcinoma","volume":"144","author":"Wang","year":"2019","journal-title":"Int. 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