{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:26:22Z","timestamp":1764588382638,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/linproxy.fan.workers.dev:443\/https\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Background: Guidelines for degenerative cerebellar ataxia neurorehabilitation suggest intensive coordinative training based on physiotherapeutic exercises. Scientific studies demonstrate virtual exergaming therapeutic value. However, patient-based personalization, post processing analyses and specific audio-visual feedbacks are not provided. This paper presents a wearable motion tracking system with recording and playback features. This system has been specifically designed for ataxic patients, for upper limbs coordination studies with the aim to retrain movement in a neurorehabilitation setting. Suggestions from neurologists and ataxia patients were considered to overcome the shortcomings of virtual systems and implement exergaming. Methods: The system consists of the mixed-reality headset Hololens2 and a proprietary exergaming implemented in Unity. Hololens2 can track and save upper limb parameters, head position and gaze direction in runtime. Results: Data collected from a healthy subject are reported to demonstrate features and outputs of the system. Conclusions: Although further improvements and validations are needed, the system meets the needs of a dynamic patient-based exergaming for patients with cerebellar ataxia. Compared with existing solutions, the mixed-reality system is designed to provide an effective and safe therapeutic exergaming that supports both primary and secondary goals of an exergaming: what a patient should do and how patient actions should be performed.<\/jats:p>","DOI":"10.3390\/s23031680","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T01:40:25Z","timestamp":1675388425000},"page":"1680","update-policy":"https:\/\/linproxy.fan.workers.dev:443\/https\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Proof of Concept Combined Using Mixed Reality for Personalized Neurorehabilitation of Cerebellar Ataxic Patients"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/linproxy.fan.workers.dev:443\/https\/orcid.org\/0000-0001-6955-7534","authenticated-orcid":false,"given":"Michela","family":"Franz\u00f2","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, \u201cSapienza\u201d University of Rome, 00184 Rome, Italy"}]},{"ORCID":"https:\/\/linproxy.fan.workers.dev:443\/https\/orcid.org\/0000-0002-6877-4120","authenticated-orcid":false,"given":"Andrada","family":"Pica","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, \u201cSapienza\u201d University of Rome, 00184 Rome, Italy"}]},{"ORCID":"https:\/\/linproxy.fan.workers.dev:443\/https\/orcid.org\/0000-0003-3897-9384","authenticated-orcid":false,"given":"Simona","family":"Pascucci","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, \u201cSapienza\u201d University of Rome, 00184 Rome, Italy"},{"name":"National Centre for Clinical Excellence, Healthcare Quality and Safety, Italian National Institute of Health, 00161 Rome, Italy"}]},{"given":"Mariano","family":"Serrao","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies, \u201cSapienza\u201d University of Rome, 00185 Rome, Italy"}]},{"given":"Franco","family":"Marinozzi","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, \u201cSapienza\u201d University of Rome, 00184 Rome, Italy"}]},{"ORCID":"https:\/\/linproxy.fan.workers.dev:443\/https\/orcid.org\/0000-0002-5641-1189","authenticated-orcid":false,"given":"Fabiano","family":"Bini","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, \u201cSapienza\u201d University of Rome, 00184 Rome, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-3-030-24230-5_2","article-title":"Smart and Assistive Walker\u2014ASBGo: Rehabilitation Robotics: A Smart\u2013Walker to Assist Ataxic Patients","volume":"Volume 1170","author":"Moreira","year":"2019","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Son, S., Lim, K.B., Kim, J., Lee, C., Cho, S.I.I., and Yoo, J. 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