File:Serpin activation by heparin (unannotated).png

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English: Some serpins are activated by cofactors. The the serpin antithrombin has an RCL (blue) where the P1 arginine (blue sticks) points inwards, preventing protease binding. Binding of heparin (green sticks) causes the P1 arginine residue to flip to an exposed position. The target protease (grey) then binds both the exposed P1 arginine as well as the heparin. The serpin then activates and heparin is released. (PDB: 2ANT, 1TB6, 1EZX​)
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Author Thomas Shafee
Other versions For annotated version , see File:Serpin activation by heparin.png

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Date/TimeThumbnailDimensionsUserComment
current11:20, 26 December 2015Thumbnail for version as of 11:20, 26 December 20152,400 × 1,131 (983 KB)Evolution and evolvability (talk | contribs)unstructured RCL loop added
13:39, 23 December 2015Thumbnail for version as of 13:39, 23 December 20152,400 × 1,140 (974 KB)Evolution and evolvability (talk | contribs)User created page with UploadWizard

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