GIPC1: Difference between revisions

{{Infobox_gene}}

'''GIPC PDZ domain containing family, member 1''' ('''GIPC1''') is a [[protein]] that in humans is encoded by the ''GIPC1'' [[gene]].<ref name="pmid9770488">{{cite journal | vauthors = De Vries L, Lou X, Zhao G, Zheng B, Farquhar MG | title = GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 21 | pages = 12340–5 | date = November 1998 | pmid = 9770488 | pmc = 22833 | doi = 10.1073/pnas.95.21.12340 | bibcode = 1998PNAS...9512340D | doi-access = free }}</ref><ref name="pmid9482110">{{cite journal | vauthors = Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P | title = The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins | journal = Oncogene | volume = 16 | issue = 5 | pages = 643–54 | date = March 1998 | pmid = 9482110 | doi = 10.1038/sj.onc.1201567 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GIPC1 GIPC PDZ domain containing family, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10755}}</ref> GIPC was originally identified as it binds specifically to the C terminus of RGS-GAIP, a protein involved in the regulation of [[G protein]] signaling.<ref name="pmid9770488"/> GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins. The human GIPC1 molecule is 333 amino acids or about 36&nbsp;kDa in molecular size and consists of a central [[PDZ domain]], a compact protein module which mediates specific protein-protein interactions. The RGS-GAIP protein interacts with this domain and many other proteins interact here or at other parts of the GIPC1 molecule. As a result, GIPC1 was independently discovered by several other groups and has a variety of alternate names, including synectin, C19orf3, RGS19IP1 and others. The GIPC1 gene family in mammals consisting of three members, so the first discovered, originally named GIPC, is now generally called GIPC1, with the other two being named GIPC2 and GIPC3.<ref name = "pmid12011974">{{cite journal | vauthors = Katoh M | title = GIPC gene family (Review) | journal = Int. J. Mol. Med. | volume = 9 | issue = 6 | pages = 585–9 | year = 2002 | pmid = 12011974 | doi = 10.3892/ijmm.9.6.585 }}</ref> The three human proteins are about 60% identical in protein sequence. GIPC1 has been shown to interact with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4, SEMA4C/semaphorin-4 and HTLV-I Tax. The general function of GIPC family proteins therefore appears to be mediating specific interactions between proteins involved in G protein signaling and membrane translocation.

* {{cite journal | vauthors = Cai H, Reed RR | title = Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1 | journal = J. Neurosci. | volume = 19 | issue = 15 | pages = 6519–27 | year = 1999 | pmid = 10414980 | doi = 10.1523/JNEUROSCI.19-15-06519.1999| pmc = 6782790 | doi-access = free }}

* {{cite journal | vauthors = Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J | title = Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25616–24 | year = 2000 | pmid = 10827173 | doi = 10.1074/jbc.M000955200 | doi-access = free }}

* {{cite journal | vauthors = Von Kap-Herr C, Kandala G, Mann SS, Hart TC, Pettenati MJ, Setaluri V | title = Assignment of PDZ domain-containing protein GIPC gene (C19orf3) to human chromosome band 19p13.1 by in situ hybridization and radiation hybrid mapping | journal = Cytogenet. Cell Genet. | volume = 89 | issue = 3–4 | pages = 234–5 | year = 2000 | pmid = 10965131 | doi = 10.1159/000015621 | s2cid = 85292825 }}

* {{cite journal | vauthors = Lou X, Yano H, Lee F, Chao MV, Farquhar MG | title = GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways | journal = Mol. Biol. Cell | volume = 12 | issue = 3 | pages = 615–27 | year = 2001 | pmid = 11251075 | pmc = 30968 | doi = 10.1091/mbc.12.3.615 }}