View source for Interleukin 5 receptor alpha subunit

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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Interleukin 5 receptor, alpha''' ('''IL5RA''') also known as '''CD125''' ('''C'''luster of '''D'''ifferentiation '''125''') is a subunit of the [[Interleukin-5 receptor]]. IL5RA also denotes its human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL5RA interleukin 5 receptor, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3568}}</ref>

== Function ==

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein ([[Syntenin-1|syntenin]]), which is required for IL5 mediated activation of the transcription factor [[SOX4]]. Six alternatively spliced transcript variants encoding three distinct [[Protein isoform|isoforms]] have been reported.<ref name="entrez"/>

== Interactions ==

Interleukin 5 receptor alpha subunit has been shown to [[Protein-protein interaction|interact]] with:
* [[Interleukin 5]],<ref name = pmid7957082>{{cite journal | vauthors = Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF | title = Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF | journal = EMBO J. | volume = 13 | issue = 21 | pages = 5176–85 | date = Nov 1994 | pmid = 7957082 | pmc = 395466 | doi =  10.1002/j.1460-2075.1994.tb06848.x}}</ref><ref name = pmid7721873>{{cite journal | vauthors = Johanson K, Appelbaum E, Doyle M, Hensley P, Zhao B, Abdel-Meguid SS, Young P, Cook R, Carr S, Matico R | title = Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins | journal = J. Biol. Chem. | volume = 270 | issue = 16 | pages = 9459–71 | date = Apr 1995 | pmid = 7721873 | doi =  10.1074/jbc.270.16.9459| doi-access = free }}</ref><ref name = pmid1732409>{{cite journal | vauthors = Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K | title = Molecular cloning and expression of the human interleukin 5 receptor | journal = J. Exp. Med. | volume = 175 | issue = 2 | pages = 341–51 | date = Feb 1992 | pmid = 1732409 | pmc = 2119102 | doi =  10.1084/jem.175.2.341}}</ref> 
* [[Janus kinase 2]],<ref name = pmid9516124>{{cite journal | vauthors = Ogata N, Kouro T, Yamada A, Koike M, Hanai N, Ishikawa T, Takatsu K | title = JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation | journal = Blood | volume = 91 | issue = 7 | pages = 2264–71 | date = Apr 1998 | pmid = 9516124 | doi =  10.1182/blood.V91.7.2264| doi-access = free }}</ref>
* [[Protein unc-119 homolog]],<ref name = pmid12496276>{{cite journal | vauthors = Cen O, Gorska MM, Stafford SJ, Sur S, Alam R | title = Identification of UNC119 as a novel activator of SRC-type tyrosine kinases | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8837–45 | date = Mar 2003 | pmid = 12496276 | doi = 10.1074/jbc.M208261200 | doi-access = free }}</ref>  and
* [[SDCBP]]<ref name = pmid11498591>{{cite journal | vauthors = Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ | title = Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein | journal = Science | volume = 293 | issue = 5532 | pages = 1136–8 | date = Aug 2001 | pmid = 11498591 | doi = 10.1126/science.1059157 | s2cid = 28003281 }}</ref>

== See also ==
* [[Cluster of differentiation]]
* [[Benralizumab]]
* [[Mepolizumab]]
* [[Reslizumab]]

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
*{{cite journal | vauthors = Isobe M, Kumura Y, Murata Y, Takaki S, Tominaga A, Takatsu K, Ogita Z | title = Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. | journal = Genomics | volume = 14 | issue = 3 | pages = 755–8 | year = 1992 | pmid = 1427903 | doi = 10.1016/S0888-7543(05)80180-6 }}
*{{cite journal | vauthors = Tuypens T, Plaetinck G, Baker E, Sutherland G, Brusselle G, Fiers W, Devos R, Tavernier J | title = Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene. | journal = Eur. Cytokine Netw. | volume = 3 | issue = 5 | pages = 451–9 | year = 1993 | pmid = 1477296 }}
*{{cite journal | vauthors = Tavernier J, Tuypens T, Plaetinck G, Verhee A, Fiers W, Devos R | title = Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 15 | pages = 7041–5 | year = 1992 | pmid = 1495999 | pmc = 49641 | doi = 10.1073/pnas.89.15.7041 | bibcode = 1992PNAS...89.7041T | doi-access = free }}
*{{cite journal | vauthors = Scott HS, Guo XH, Hopwood JJ, Morris CP | title = Structure and sequence of the human alpha-L-iduronidase gene. | journal = Genomics | volume = 13 | issue = 4 | pages = 1311–3 | year = 1992 | pmid = 1505961 | doi = 10.1016/0888-7543(92)90053-U }}
*{{cite journal | vauthors = Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K | title = Molecular cloning and expression of the human interleukin 5 receptor. | journal = J. Exp. Med. | volume = 175 | issue = 2 | pages = 341–51 | year = 1992 | pmid = 1732409 | pmc = 2119102 | doi = 10.1084/jem.175.2.341 }}
*{{cite journal | vauthors = Tavernier J, Devos R, Cornelis S, Tuypens T, Van der Heyden J, Fiers W, Plaetinck G | title = A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. | journal = Cell | volume = 66 | issue = 6 | pages = 1175–84 | year = 1991 | pmid = 1833065 | doi = 10.1016/0092-8674(91)90040-6 | s2cid = 54277241 }}
*{{cite journal | vauthors = Johanson K, Appelbaum E, Doyle M, Hensley P, Zhao B, Abdel-Meguid SS, Young P, Cook R, Carr S, Matico R | title = Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins. | journal = J. Biol. Chem. | volume = 270 | issue = 16 | pages = 9459–71 | year = 1995 | pmid = 7721873 | doi = 10.1074/jbc.270.16.9459 | doi-access = free }}
*{{cite journal | vauthors = Sun Z, Yergeau DA, Tuypens T, Tavernier J, Paul CC, Baumann MA, Tenen DG, Ackerman SJ | title = Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene. | journal = J. Biol. Chem. | volume = 270 | issue = 3 | pages = 1462–71 | year = 1995 | pmid = 7836416 | doi = 10.1074/jbc.270.3.1462 | doi-access = free }}
*{{cite journal | vauthors = Hori K, Hirashima M, Ueno M, Matsuda M, Waga S, Tsurufuji S, Yodoi J | title = Regulation of eosinophil migration by adult T cell leukemia-derived factor. | journal = J. Immunol. | volume = 151 | issue = 10 | pages = 5624–30 | year = 1993 | doi = 10.4049/jimmunol.151.10.5624 | pmid = 8228251 | doi-access = free }}
*{{cite journal | vauthors = Huston MM, Moore JP, Mettes HJ, Tavana G, Huston DP | title = Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis. | journal = J. Immunol. | volume = 156 | issue = 4 | pages = 1392–401 | year = 1996 | doi = 10.4049/jimmunol.156.4.1392 | pmid = 8568239 | doi-access = free }}
*{{cite journal | vauthors = Monahan J, Siegel N, Keith R, Caparon M, Christine L, Compton R, Cusik S, Hirsch J, Huynh M, Devine C, Polazzi J, Rangwala S, Tsai B, Portanova J | title = Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. | journal = J. Immunol. | volume = 159 | issue = 8 | pages = 4024–34 | year = 1997 | doi = 10.4049/jimmunol.159.8.4024 | pmid = 9378992 | s2cid = 22709807 }}
*{{cite journal | vauthors = Ogata N, Kouro T, Yamada A, Koike M, Hanai N, Ishikawa T, Takatsu K | title = JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. | journal = Blood | volume = 91 | issue = 7 | pages = 2264–71 | year = 1998 | pmid = 9516124 | doi =  10.1182/blood.V91.7.2264| doi-access = free }}
*{{cite journal | vauthors = Tavernier J, Van der Heyden J, Verhee A, Brusselle G, Van Ostade X, Vandekerckhove J, North J, Rankin SM, Kay AB, Robinson DS | title = Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit. | journal = Blood | volume = 95 | issue = 5 | pages = 1600–7 | year = 2000 | pmid = 10688814 | doi =  10.1182/blood.V95.5.1600.005k22_1600_1607}}
*{{cite journal | vauthors = Czabotar PE, Holland J, Sanderson CJ | title = Identification of regions within the third FnIII-like domain of the IL-5Ralpha involved in IL-5 interaction. | journal = Cytokine | volume = 12 | issue = 7 | pages = 867–73 | year = 2000 | pmid = 10880230 | doi = 10.1006/cyto.1999.0663 }}
*{{cite journal | vauthors = Plugariu CG, Wu SJ, Zhang W, Chaiken I | title = Multisite mutagenesis of interleukin 5 differentiates sites for receptor recognition and receptor activation. | journal = Biochemistry | volume = 39 | issue = 48 | pages = 14939–49 | year = 2001 | pmid = 11101310 | doi = 10.1021/bi001467p }}
*{{cite journal | vauthors = Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ | title = Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. | journal = Science | volume = 293 | issue = 5532 | pages = 1136–8 | year = 2001 | pmid = 11498591 | doi = 10.1126/science.1059157 | s2cid = 28003281 }}
*{{cite journal | vauthors = Upham JW, Sehmi R, Hayes LM, Howie K, Lundahl J, Denburg JA | title = Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells. | journal = J. Allergy Clin. Immunol. | volume = 109 | issue = 2 | pages = 307–13 | year = 2002 | pmid = 11842302 | doi = 10.1067/mai.2002.121527 | doi-access = free }}
*{{cite journal | vauthors = Rizzo CA, Yang R, Greenfeder S, Egan RW, Pauwels RA, Hey JA | title = The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness. | journal = J. Allergy Clin. Immunol. | volume = 109 | issue = 3 | pages = 404–9 | year = 2002 | pmid = 11897983 | doi = 10.1067/mai.2002.122459 }}
*{{cite journal | vauthors = Scibek JJ, Evergren E, Zahn S, Canziani GA, Van Ryk D, Chaiken IM | title = Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes. | journal = Anal. Biochem. | volume = 307 | issue = 2 | pages = 258–65 | year = 2003 | pmid = 12202242 | doi = 10.1016/S0003-2697(02)00043-X }}
*{{cite journal | vauthors = Liu LY, Sedgwick JB, Bates ME, Vrtis RF, Gern JE, Kita H, Jarjour NN, Busse WW, Kelly EA | title = Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge. | journal = J. Immunol. | volume = 169 | issue = 11 | pages = 6452–8 | year = 2002 | pmid = 12444154 | doi = 10.4049/jimmunol.169.11.6452 | doi-access = free }}
{{refend}}

== External links ==
* {{MeshName|IL5RA+protein,+human}}
* {{PDBe-KB2|Q01344|Interleukin-5 receptor subunit alpha}}

{{NLM content}}
{{Cytokine receptors}}
{{Clusters of differentiation}}
{{Interleukin receptor modulators}}

[[Category:Clusters of differentiation]]