View source for KIF1B

{{Short description|Mammalian protein found in Homo sapiens}}
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{{Use dmy dates|date=April 2023}}
{{Infobox_gene}}
'''Kinesin-like protein KIF1B''' is a [[protein]] that in humans is encoded by the ''KIF1B'' [[gene]].<ref name="pmid11389829">{{cite journal |vauthors=Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N | title = Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta | journal = Cell | volume = 105 | issue = 5 | pages = 587–97 |date=Jun 2001 | pmid = 11389829 | doi =10.1016/S0092-8674(01)00363-4  | s2cid = 17303998 | doi-access = free }}</ref><ref name="pmid10762626">{{cite journal |vauthors=Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, Ohira M, Tomioka N, Nomura N, Sakiyama S, Kubo O, Takakura K, Hori T, Nakagawara A | title = Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2 | journal = Int J Oncol | volume = 16 | issue = 5 | pages = 907–16 |date=May 2000 | pmid = 10762626 | doi =  10.3892/ijo.16.5.907}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIF1B kinesin family member 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23095}}</ref>

==Clinical significance==
It is associated with [[Charcot–Marie–Tooth disease]], type 2A1.<ref name="entrez" />

==Interactions==
KIF1B has been shown to [[Protein-protein interaction|interact]] with [[GIPC1]].<ref name=pmid10198040>{{cite journal |last=Bunn |first=R C |author2=Jensen M A |author3=Reed B C  |date=Apr 1999|title=Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton |journal=Mol. Biol. Cell |volume=10 |issue=4 |pages=819–32 | issn = 1059-1524| pmid = 10198040 | pmc = 25204 | doi=10.1091/mbc.10.4.819}}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal   |vauthors=Nangaku M, Sato-Yoshitake R, Okada Y, etal |title=KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria |journal=Cell |volume=79 |issue= 7 |pages= 1209–20 |year= 1995 |pmid= 7528108 |doi=10.1016/0092-8674(94)90012-4  |s2cid=38430180 }}
*{{cite journal  |vauthors=Gong TL, Burmeister M, Lomax MI |title=The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36 |journal=Mamm. Genome |volume=7 |issue= 10 |pages= 790–1 |year= 1997 |pmid= 8854876 |doi=10.1007/s003359900237  |s2cid=40174732 }}
*{{cite journal   |vauthors=Saito M, Hayashi Y, Suzuki T, etal |title=Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A |journal=Neurology |volume=49 |issue= 6 |pages= 1630–5 |year= 1998 |pmid= 9409358 |doi=  10.1212/wnl.49.6.1630|s2cid=32002103 }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Miyajima N, etal |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31  |doi-access=free }}
*{{cite journal  |vauthors=Bunn RC, Jensen MA, Reed BC |title=Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton |journal=Mol. Biol. Cell |volume=10 |issue= 4 |pages= 819–32 |year= 1999 |pmid= 10198040 |doi=  10.1091/mbc.10.4.819| pmc=25204  }}
*{{cite journal   |vauthors=Conforti L, Buckmaster EA, Tarlton A, etal |title=The major brain isoform of kif1b lacks the putative mitochondria-binding domain |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 617–22 |year= 1999 |pmid= 10341097 |doi=10.1007/s003359901056  |s2cid=24223913 }}
*{{cite journal   |vauthors=Nagase T, Kikuno R, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143  |doi-access=free }}
*{{cite journal   |vauthors=Yang HW, Chen YZ, Takita J, etal |title=Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2 |journal=Oncogene |volume=20 |issue= 36 |pages= 5075–83 |year= 2001 |pmid= 11526494 |doi= 10.1038/sj.onc.1204456 |s2cid=20404213 |doi-access=  }}
*{{cite journal   |vauthors=Mok H, Shin H, Kim S, etal |title=Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins |journal=J. Neurosci. |volume=22 |issue= 13 |pages= 5253–8 |year= 2002 |pmid= 12097473 |pmc=6758229 |doi=10.1523/JNEUROSCI.22-13-05253.2002 }}
*{{cite journal   |vauthors=Nakamura N, Miyake Y, Matsushita M, etal |title=KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles |journal=J. Biochem. |volume=132 |issue= 3 |pages= 483–91 |year= 2003 |pmid= 12204119 |doi=  10.1093/oxfordjournals.jbchem.a003246}}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  |vauthors=Huang YS, Carson JH, Barbarese E, Richter JD |title=Facilitation of dendritic mRNA transport by CPEB |journal=Genes Dev. |volume=17 |issue= 5 |pages= 638–53 |year= 2003 |pmid= 12629046 |doi= 10.1101/gad.1053003  | pmc=196011 }}
*{{cite journal   |vauthors=Chen YY, Takita J, Chen YZ, etal |title=Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma |journal=Int. J. Oncol. |volume=23 |issue= 3 |pages= 737–44 |year= 2004 |pmid= 12888911 |doi= 10.3892/ijo.23.3.737 }}
*{{cite journal  |vauthors=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200 |doi-access= free }}
*{{cite journal  |vauthors=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654–65 |year= 2004 |pmid= 14697242 |doi=10.1016/j.bbrc.2003.12.001  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |doi-access=free |bibcode=2004CBio...14.1436J }}
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==External links==
* [https://www.ncbi.nlm.nih.gov/books/NBK1285/  GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2]

{{Cytoskeletal proteins}}


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