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{{Short description|Protein-coding gene in the species Homo sapiens}}
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'''Dickkopf-related protein 2''' is a [[protein]] that in humans is encoded by the ''DKK2'' [[gene]].<ref name="pmid10570958">{{cite journal | author = Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA | title = Functional and structural diversity of the human Dickkopf gene family | journal = Gene | volume = 238 | issue = 2 | pages = 301–13 |date=Dec 1999 | pmid = 10570958 | pmc = | doi =10.1016/S0378-1119(99)00365-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27123| accessdate = }}</ref>


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'''Dickkopf-related protein 2''' is a [[protein]] in the [[Dickkopf]] family that in humans is encoded by the ''DKK2'' [[gene]].<ref name="pmid10570958">{{cite journal | vauthors = Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA | display-authors = 6 | title = Functional and structural diversity of the human Dickkopf gene family | journal = Gene | volume = 238 | issue = 2 | pages = 301–13 | date = October 1999 | pmid = 10570958 | doi = 10.1016/S0378-1119(99)00365-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27123}}</ref>
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{{PBB_Summary
| section_title =
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| summary_text = This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).<ref name="entrez" />
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This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two [[cysteine]] rich regions and is involved in [[embryonic development]] through its interactions with the [[Wnt signaling pathway]].
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==References==

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It can act as either an [[agonist]] or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 ([[LRP6]]).<ref name="entrez" />

== See also ==
* [[Hairy palms and soles]]<ref>{{cite journal | vauthors = Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, Wu D, Li Y, Xu M, Millar SE | display-authors = 6 | title = Regional Control of Hairless versus Hair-Bearing Skin by Dkk2 | journal = Cell Reports | volume = 25 | issue = 11 | pages = 2981–2991.e3 | date = December 2018 | pmid = 30509557 | pmc = 6345517 | doi = 10.1016/j.celrep.2018.11.017 }}</ref>

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== References ==
{{reflist}}
{{reflist}}

==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Wu W, Glinka A, Delius H, Niehrs C | title = Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling | journal = Current Biology | volume = 10 | issue = 24 | pages = 1611–4 | year = 2001 | pmid = 11137016 | doi = 10.1016/S0960-9822(00)00868-X | s2cid = 6397269 | doi-access = free }}
{{PBB_Further_reading
* {{cite journal | vauthors = Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C | title = LDL-receptor-related protein 6 is a receptor for Dickkopf proteins | journal = Nature | volume = 411 | issue = 6835 | pages = 321–5 | date = May 2001 | pmid = 11357136 | doi = 10.1038/35077108 | s2cid = 4323027 }}
| citations =
*{{cite journal | author=Wu W, Glinka A, Delius H, Niehrs C |title=Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. |journal=Curr. Biol. |volume=10 |issue= 24 |pages= 1611–4 |year= 2001 |pmid= 11137016 |doi=10.1016/S0960-9822(00)00868-X }}
* {{cite journal | vauthors = Li L, Mao J, Sun L, Liu W, Wu D | title = Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 5977–81 | date = February 2002 | pmid = 11742004 | doi = 10.1074/jbc.M111131200 | doi-access = free }}
*{{cite journal | author=Mao B, Wu W, Li Y |title=LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. |journal=Nature |volume=411 |issue= 6835 |pages= 321–5 |year= 2001 |pmid= 11357136 |doi= 10.1038/35077108 |display-authors=etal}}
* {{cite journal | vauthors = Brott BK, Sokol SY | title = Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins | journal = Molecular and Cellular Biology | volume = 22 | issue = 17 | pages = 6100–10 | date = September 2002 | pmid = 12167704 | pmc = 133995 | doi = 10.1128/MCB.22.17.6100-6110.2002 }}
*{{cite journal | author=Li L, Mao J, Sun L |title=Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 5977–81 |year= 2002 |pmid= 11742004 |doi= 10.1074/jbc.M111131200 |display-authors=etal}}
* {{cite journal | vauthors = Mao B, Niehrs C | title = Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling | journal = Gene | volume = 302 | issue = 1–2 | pages = 179–83 | date = January 2003 | pmid = 12527209 | doi = 10.1016/S0378-1119(02)01106-X }}
*{{cite journal | author=Brott BK, Sokol SY |title=Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6100–10 |year= 2002 |pmid= 12167704 |doi=10.1128/MCB.22.17.6100-6110.2002 | pmc=133995 }}
* {{cite journal | vauthors = Kuphal S, Lodermeyer S, Bataille F, Schuierer M, Hoang BH, Bosserhoff AK | title = Expression of Dickkopf genes is strongly reduced in malignant melanoma | journal = Oncogene | volume = 25 | issue = 36 | pages = 5027–36 | date = August 2006 | pmid = 16568085 | doi = 10.1038/sj.onc.1209508 | doi-access = | s2cid = 12065588 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal | author=Mao B, Niehrs C |title=Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. |journal=Gene |volume=302 |issue= 1-2 |pages= 179–83 |year= 2003 |pmid= 12527209 |doi=10.1016/S0378-1119(02)01106-X }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Kuphal S, Lodermeyer S, Bataille F |title=Expression of Dickkopf genes is strongly reduced in malignant melanoma. |journal=Oncogene |volume=25 |issue= 36 |pages= 5027–36 |year= 2006 |pmid= 16568085 |doi= 10.1038/sj.onc.1209508 |display-authors=etal}}
}}
{{refend}}
{{refend}}


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{{gene-4-stub}}
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Latest revision as of 09:43, 8 January 2024

DKK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2
External IDsOMIM: 605415; MGI: 1890663; HomoloGene: 8681; GeneCards: DKK2; OMA:DKK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

27123

56811

Ensembl

ENSG00000155011

ENSMUSG00000028031

UniProt

Q9UBU2

Q9QYZ8

RefSeq (mRNA)

NM_014421

NM_020265

RefSeq (protein)

NP_055236

NP_064661

Location (UCSC)Chr 4: 106.92 – 107.28 MbChr 3: 131.79 – 131.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene.[5][6]

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.

It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).[6]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155011 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028031 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (October 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
  6. ^ a b "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".
  7. ^ Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, et al. (December 2018). "Regional Control of Hairless versus Hair-Bearing Skin by Dkk2". Cell Reports. 25 (11): 2981–2991.e3. doi:10.1016/j.celrep.2018.11.017. PMC 6345517. PMID 30509557.

Further reading

[edit]


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