DKK2: Difference between revisions

DKK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JTK
Identifiers
Aliases	DKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2
External IDs	OMIM: 605415; MGI: 1890663; HomoloGene: 8681; GeneCards: DKK2; OMA:DKK2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	107,283,806 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	131,886,065 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of hip; ; buccal mucosa cell; ; Achilles tendon; ; testicle; ; Skeletal muscle tissue of rectus abdominis; ; hair follicle; ; thoracic diaphragm; ; right lung; ; muscle of thigh;
	Top expressed in
	vestibular membrane of cochlear duct; ; external carotid artery; ; internal carotid artery; ; iris; ; glomerulus; ; umbilical cord; ; conjunctival fornix; ; saccule; ; gastrula; ; glomerular mesangium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	co-receptor binding; receptor antagonist activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of canonical Wnt signaling pathway; multicellular organism development; negative regulation of Wnt signaling pathway; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	27123
	56811
	ENSG00000155011
	ENSMUSG00000028031
	Q9UBU2
	Q9QYZ8
	NM_014421
	NM_020265
	NP_055236
	NP_064661
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 18:51, 21 May 2016

Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155011 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028031 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA (Dec 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
^ "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".

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+{{Multiple issues|
+{{Underlinked|date=May 2016}}
 {{Orphan|date=February 2009}}
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 {{Infobox_gene}}
-'''Dickkopf-related protein 2''' is a [[protein]] that in humans is encoded by the ''DKK2'' [[gene]].<ref name="pmid10570958">{{cite journal | author = Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA | title = Functional and structural diversity of the human Dickkopf gene family | journal = Gene | volume = 238 | issue = 2 | pages = 301–13 |date=Dec 1999 | pmid = 10570958 | pmc =  | doi =10.1016/S0378-1119(99)00365-0  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27123| accessdate = }}</ref>
+'''Dickkopf-related protein 2''' is a [[protein]] that in humans is encoded by the ''DKK2'' [[gene]].<ref name="pmid10570958">{{cite journal | vauthors = Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA | title = Functional and structural diversity of the human Dickkopf gene family | journal = Gene | volume = 238 | issue = 2 | pages = 301–13 |date=Dec 1999 | pmid = 10570958 | pmc =  | doi =10.1016/S0378-1119(99)00365-0  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27123| accessdate = }}</ref>
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 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Wu W, Glinka A, Delius H, Niehrs C |title=Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. |journal=Curr. Biol. |volume=10 |issue= 24 |pages= 1611–4 |year= 2001 |pmid= 11137016 |doi=10.1016/S0960-9822(00)00868-X  }}
+*{{cite journal  | vauthors=Wu W, Glinka A, Delius H, Niehrs C |title=Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. |journal=Curr. Biol. |volume=10 |issue= 24 |pages= 1611–4 |year= 2001 |pmid= 11137016 |doi=10.1016/S0960-9822(00)00868-X  }}
-*{{cite journal  | author=Mao B, Wu W, Li Y |title=LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. |journal=Nature |volume=411 |issue= 6835 |pages= 321–5 |year= 2001 |pmid= 11357136 |doi= 10.1038/35077108 |display-authors=etal}}
+*{{cite journal  | vauthors=Mao B, Wu W, Li Y |title=LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. |journal=Nature |volume=411 |issue= 6835 |pages= 321–5 |year= 2001 |pmid= 11357136 |doi= 10.1038/35077108 |display-authors=etal}}
-*{{cite journal  | author=Li L, Mao J, Sun L |title=Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 5977–81 |year= 2002 |pmid= 11742004 |doi= 10.1074/jbc.M111131200 |display-authors=etal}}
+*{{cite journal  | vauthors=Li L, Mao J, Sun L |title=Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 5977–81 |year= 2002 |pmid= 11742004 |doi= 10.1074/jbc.M111131200 |display-authors=etal}}
-*{{cite journal  | author=Brott BK, Sokol SY |title=Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6100–10 |year= 2002 |pmid= 12167704 |doi=10.1128/MCB.22.17.6100-6110.2002  | pmc=133995  }}
+*{{cite journal  | vauthors=Brott BK, Sokol SY |title=Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6100–10 |year= 2002 |pmid= 12167704 |doi=10.1128/MCB.22.17.6100-6110.2002  | pmc=133995  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Mao B, Niehrs C |title=Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. |journal=Gene |volume=302 |issue= 1-2 |pages= 179–83 |year= 2003 |pmid= 12527209 |doi=10.1016/S0378-1119(02)01106-X  }}
+*{{cite journal  | vauthors=Mao B, Niehrs C |title=Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. |journal=Gene |volume=302 |issue= 1-2 |pages= 179–83 |year= 2003 |pmid= 12527209 |doi=10.1016/S0378-1119(02)01106-X  }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
+*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Kuphal S, Lodermeyer S, Bataille F |title=Expression of Dickkopf genes is strongly reduced in malignant melanoma. |journal=Oncogene |volume=25 |issue= 36 |pages= 5027–36 |year= 2006 |pmid= 16568085 |doi= 10.1038/sj.onc.1209508 |display-authors=etal}}
+*{{cite journal  | vauthors=Kuphal S, Lodermeyer S, Bataille F |title=Expression of Dickkopf genes is strongly reduced in malignant melanoma. |journal=Oncogene |volume=25 |issue= 36 |pages= 5027–36 |year= 2006 |pmid= 16568085 |doi= 10.1038/sj.onc.1209508 |display-authors=etal}}
 }}
 {{refend}}
-{{gene-4-stub}}
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+{{Uncategorized stub|date=May 2016}}