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| summary_text = This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).<ref name="entrez" /> |
| summary_text = This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).<ref name="entrez" /> |
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==See Also== |
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* [[Hairy palms and soles]] <ref>{{cite journal |last1=Song |first1=Yaolin |last2=Boncompagni |first2=Ana C. |last3=Kim |first3=Sang-Seok |last4=Gochnauer |first4=Heather R. |last5=Zhang |first5=Yuhang |last6=Loots |first6=Gabriela G. |last7=Wu |first7=Dianqing |last8=Li |first8=Yulin |last9=Xu |first9=Mingang |last10=Millar |first10=Sarah E. |title=Regional Control of Hairless versus Hair-Bearing Skin by Dkk2 |journal=Cell Reports |date=December 2018 |volume=25 |issue=11 |pages=2981–2991.e3 |doi=10.1016/j.celrep.2018.11.017}}</ref> |
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==References== |
==References== |
Revision as of 23:42, 21 February 2019
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | DKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605415; MGI: 1890663; HomoloGene: 8681; GeneCards: DKK2; OMA:DKK2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2 gene.[5][6]
See Also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000155011 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028031 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA (Dec 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
- ^ "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".
- ^ Song, Yaolin; Boncompagni, Ana C.; Kim, Sang-Seok; Gochnauer, Heather R.; Zhang, Yuhang; Loots, Gabriela G.; Wu, Dianqing; Li, Yulin; Xu, Mingang; Millar, Sarah E. (December 2018). "Regional Control of Hairless versus Hair-Bearing Skin by Dkk2". Cell Reports. 25 (11): 2981–2991.e3. doi:10.1016/j.celrep.2018.11.017.
Further reading