SLC16A11

SLC16A11
Identifiers
Aliases	SLC16A11, MCT11, solute carrier family 16 member 11, MCT 11
External IDs	OMIM: 615765; MGI: 2663709; HomoloGene: 27409; GeneCards: SLC16A11; OMA:SLC16A11 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,044,092 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,107,243 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; olfactory zone of nasal mucosa; ; parotid gland; ; minor salivary glands; ; palpebral conjunctiva; ; skin of abdomen; ; skin of leg; ; right lobe of liver;
	Top expressed in
	cerebellar cortex; ; right kidney; ; olfactory epithelium; ; motor neuron; ; superior frontal gyrus; ; trachea; ; primary visual cortex; ; conjunctival fornix; ; dentate gyrus of hippocampal formation granule cell; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity; monocarboxylic acid transmembrane transporter activity; protein binding; pyruvate transmembrane transporter activity;
Cellular component	membrane; integral component of membrane; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of plasma membrane; plasma membrane;
Biological process	transmembrane transport; lipid metabolism; monocarboxylic acid transport; pyruvate transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	162515
	216867
	ENSG00000174326
	ENSMUSG00000040938
	Q8NCK7
	Q5NC32
	NM_153357; NM_001370549; NM_001370553
	NM_001114970; NM_001114971; NM_153081
	NP_699188; NP_001357478; NP_001357482
	NP_694721
	Wikidata
View/Edit Human	View/Edit Mouse

Monocarboxylate transporter 11 (MCT 11) is a protein that in humans is encode by the SLC16A11 gene.^[5]

Variants in this gene are associated with increased body-mass index^[6] and type 2 diabetes.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174326 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040938 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt". www.uniprot.org. Retrieved 2024-07-16.
^ Mardones L, Petermann-Rocha F, Martinez-Sanguinetti MA, Leiva AM, Troncoso-Pantoja C, Martorell M, et al. (November 2021). "Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population". Archives of Endocrinology and Metabolism. 65 (3): 305–314. doi:10.20945/2359-3997000000359. PMC 10065347. PMID 33909378.
^ Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, et al. (February 2014). "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico". Nature. 506 (7486): 97–101. Bibcode:2014Natur.506...97T. doi:10.1038/nature12828. PMC 4127086. PMID 24390345.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174326 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040938 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "UniProt". www.uniprot.org. Retrieved 2024-07-16.

[6] Mardones L, Petermann-Rocha F, Martinez-Sanguinetti MA, Leiva AM, Troncoso-Pantoja C, Martorell M, et al. (November 2021). "Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population". Archives of Endocrinology and Metabolism. 65 (3): 305–314. doi:10.20945/2359-3997000000359. PMC 10065347. PMID 33909378.

[7] Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, et al. (February 2014). "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico". Nature. 506 (7486): 97–101. Bibcode:2014Natur.506...97T. doi:10.1038/nature12828. PMC 4127086. PMID 24390345.

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