GSTT1

GSTT1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2C3N, 2C3Q, 2C3T
Identifiers
Aliases	GSTT1, glutathione S-transferase theta 1
External IDs	OMIM: 600436; GeneCards: GSTT1; OMA:GSTT1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	24,384,680 bp
RNA expression pattern
	Top expressed in
	vena cava; ; thoracic diaphragm; ; adrenal gland; ; external globus pallidus; ; jejunal mucosa; ; right ventricle; ; coronary artery; ; Skeletal muscle tissue of rectus abdominis; ; lateral nuclear group of thalamus; ; cingulate gyrus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glutathione peroxidase activity; glutathione transferase activity; protein binding;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	glutathione derivative biosynthetic process; glutathione metabolic process; cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	2952
	n/a
	ENSG00000277656
	n/a
	P30711
	n/a
NM_000853; NM_001293807; NM_001293808; NM_001293809; NM_001293810;
	NM_001293811; NM_001293812; NM_001293813; NM_001293814
	n/a
NP_000844; NP_001280736; NP_001280737; NP_001280738; NP_001280739;
	NP_001280740; NP_001280741; NP_001280742; NP_001280743
	n/a
	Wikidata
View/Edit Human

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.^[2]

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.^[3]

References

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
^ "Entrez Gene: GSTT1 glutathione S-transferase theta 1".

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8617495-2] Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.

[3] "Entrez Gene: GSTT1 glutathione S-transferase theta 1".

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