Fenilbutazon – razlika između verzija
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| drug_name = Fenilbutazon |
| drug_name = Fenilbutazon |
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| [[Rastvorljivost]]<ref>{{cite pmid|11749573|noedit}}</ref> (''logS'', log(''mol/L'')) || -4,0 |
| [[Rastvorljivost]]<ref>{{cite pmid|11749573|noedit}}</ref> (''logS'', log(''mol/L'')) || -4,0 |
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| [[Polarna površina molekula|Polarna površina]]<ref>{{cite pmid|11020286|noedit}}</ref> (''PSA'', [[ |
| [[Polarna površina molekula|Polarna površina]]<ref>{{cite pmid|11020286|noedit}}</ref> (''PSA'', [[Angstrem (jedinica)|Å<sup>2</sup>]]) || 40,6 |
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{{Portal-lat|Medicina|Hemija}} |
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{{Commonscat-lat|Phenylbutazone}} |
{{Commonscat-lat|Phenylbutazone}} |
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* [http://www.drugbank.ca/drugs/DB00812 Phenylbutazone] |
* [http://www.drugbank.ca/drugs/DB00812 Phenylbutazone] |
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[[Kategorija:Nesteroidni antiinflamatorni lekovi]] |
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Aktualna verzija od 19. decembra 2024. u 20:23
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| Klinički podaci | |||
|---|---|---|---|
| Robne marke | 'Esteve', Alindor, Alka Butazolidin, Alkabutazona | ||
| AHFS/Drugs.com | Monografija | ||
| Identifikatori | |||
| CAS broj | 50-33-9 | ||
| ATC kod | M01AA01 , M02AA01 | ||
| PubChem[1][2] | 4781 | ||
| DrugBank | DB00812 | ||
| ChemSpider[3] | 4617 | ||
| KEGG[4] | C07440 
| ||
| ChEBI | CHEBI:48574
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| ChEMBL[5] | CHEMBL101
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| Hemijski podaci | |||
| Formula | C19H20N2O2 | ||
| Mol. masa | 308,374 | ||
| SMILES | eMolekuli & PubHem | ||
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| Fizički podaci | |||
| Tačka topljenja | 105 °C (221 °F) | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
| Način primene | Oralno | ||
Fenilbutazon je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 308,374 Da.[6][7]
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 2 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 5 |
| Particioni koeficijent[8] (ALogP) | 4,0 |
| Rastvorljivost[9] (logS, log(mol/L)) | -4,0 |
| Polarna površina[10] (PSA, Å2) | 40,6 |
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
- ↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
- ↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.
- ↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
