Aceklofenak – razlika između verzija
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| drug_name = Aceklofenak |
| drug_name = Aceklofenak |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 93645 |
| ChEMBL = 93645 |
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| [[Rastvorljivost]]<ref>{{cite pmid|11749573|noedit}}</ref> (''logS'', log(''mol/L'')) || -5,5 |
| [[Rastvorljivost]]<ref>{{cite pmid|11749573|noedit}}</ref> (''logS'', log(''mol/L'')) || -5,5 |
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| [[Polarna površina molekula|Polarna površina]]<ref>{{cite pmid|11020286|noedit}}</ref> (''PSA'', [[ |
| [[Polarna površina molekula|Polarna površina]]<ref>{{cite pmid|11020286|noedit}}</ref> (''PSA'', [[Angstrem (jedinica)|''Å''<sup>2</sup>]]) || 75,6 |
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* {{FoyePrinciplesMedChem6th}} |
* {{FoyePrinciplesMedChem6th}} |
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== Vanjske veze == |
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{{Portal-lat|Medicina|Hemija}} |
{{Portal-lat|Medicina|Hemija}} |
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{{Commonscat-lat|Aceclofenac}} |
{{Commonscat-lat|Aceclofenac}} |
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* [http://www.drugbank.ca/drugs/ Aceclofenac] |
* [http://www.drugbank.ca/drugs/ Aceclofenac] |
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{{Medicinsko upozorenje-lat}} |
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{{Nesteroidni antiinflamatorni lek}} |
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[[Kategorija:Karboksilne kiseline]] |
[[Kategorija:Karboksilne kiseline]] |
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Aktualna verzija od 19. decembra 2024. u 22:47
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| Klinički podaci | |||
|---|---|---|---|
| AHFS/Drugs.com | Monografija | ||
| Identifikatori | |||
| CAS broj | 89796-99-6 | ||
| ATC kod | M01AB16 M02AA25 | ||
| PubChem[1][2] | 71771 | ||
| ChemSpider[3] | 64809 | ||
| UNII | RPK779R03H 
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| KEGG[4] | D01545
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| ChEBI | CHEBI:31159
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| ChEMBL[5] | CHEMBL93645
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| Hemijski podaci | |||
| Formula | C16H13Cl2NO4 | ||
| Mol. masa | 354,185 | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Aceklofenak je organsko jedinjenje, koje sadrži 16 atoma ugljenika i ima molekulsku masu od 354,185 Da.
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 5 |
| Broj donora vodonika | 2 |
| Broj rotacionih veza | 7 |
| Particioni koeficijent[6] (ALogP) | 4,1 |
| Rastvorljivost[7] (logS, log(mol/L)) | -5,5 |
| Polarna površina[8] (PSA, Å2) | 75,6 |
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
- ↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.
- ↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
