Oksaprozin – razlika između verzija

Oksaprozin
Klinički podaci
Robne marke	Alvo, Daypro, Daypro Alta, Deflam
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	21256-18-8
ATC kod	M01AE12
PubChem	4614
DrugBank	DB00991
ChemSpider	4453
KEGG	C07356
ChEMBL	CHEMBL1071
Hemijski podaci
Formula	C18H15NO3
Mol. masa	293,317
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21); Key: OFPXSFXSNFPTHF-UHFFFAOYSA-N
Fizički podaci
Tačka topljenja	158-159 °C (-96 °F)
Farmakokinetički podaci
Poluvreme eliminacije	54,9 h
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Oralno

Interaktivna pretraga historije

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Verzija od 8. aprila 2014. u 09:22

Oksaprozin je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 293,317 Da.^[6]^[7]^[8]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	1
Broj rotacionih veza	5
Particioni koeficijent^[9] (ALogP)	3,6
Rastvorljivost^[10] (logS, log(mol/L))	-5,3
Polarna površina^[11] (PSA, Å²)	63,3

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. PMID 15324531
↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682. edit
↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412. edit
↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573. edit
↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286. edit

Literatura

Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Oxaprozin

Šablon:Medicinsko upozorenje-lat

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. PMID 15324531

[7] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682. edit

[8] David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412. edit

[9] Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.

[10] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573. edit

[11] Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286. edit

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@@ Red 12: / Red 12: @@
 <!-- Clinical data -->
-| tradename         = Alvo, Daypro, Daypro Alta, Deflam}-
+| tradename         = Alvo, Daypro, Daypro Alta, Deflam
 | Drugs.com         = {{drugs.com-lat|monograph|Oxaprozin}}
 | MedlinePlus       =
@@ Red 80: / Red 80: @@
 | sec_combustion    =
 }}
-'''Oksaprozin''' je [[organsko jedinjenje]], koje sadrži 18 [[atom]]a [[ugljenik]]a i ima [[Молекулска маса|molekulsku masu]] od 293,317 [[Јединица атомске масе|Da}-]].<ref>Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. [[PubMed|PMID]] [http://www.ncbi.nlm.nih.gov/pubmed/15324531 15324531]}-</ref><ref>{{Cite pmid|21059682}}</ref><ref>{{cite pmid|18048412}}</ref>
+'''Oksaprozin''' je [[organsko jedinjenje]], koje sadrži 18 [[atom]]a [[ugljenik]]a i ima [[Молекулска маса|molekulsku masu]] od 293,317 [[Јединица атомске масе|Da]].<ref>Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. [[PubMed|PMID]] [http://www.ncbi.nlm.nih.gov/pubmed/15324531 15324531]</ref><ref>{{Cite pmid|21059682}}</ref><ref>{{cite pmid|18048412}}</ref>
 == Osobine ==
@@ Red 93: / Red 93: @@
 | [[Геометрија молекула|Broj rotacionih veza]] || 5
 |-
-| [[Particioni koeficijent]]<ref>{{cite doi/10.1021/jp980230o}}</ref> (''ALogP'')}- || 3,6
+| [[Particioni koeficijent]]<ref>{{cite doi/10.1021/jp980230o}}</ref> (''ALogP'') || 3,6
 |-
-| [[Rastvorljivost]]<ref>{{cite pmid|11749573}}</ref> (''logS'', log(''mol/L''}-)) || -5,3
+| [[Rastvorljivost]]<ref>{{cite pmid|11749573}}</ref> (''logS'', log(''mol/L'')) || -5,3
 |-
-| [[Polarna površina molekula|Polarna površina]]<ref>{{cite pmid|11020286}}</ref> (''PSA''}-, [[Ангстрем (јединица)|Å<sup>2</sup>]]) || 63,3
+| [[Polarna površina molekula|Polarna površina]]<ref>{{cite pmid|11020286}}</ref> (''PSA'', [[Ангстрем (јединица)|Å<sup>2</sup>]]) || 63,3
 |}
@@ Red 111: / Red 111: @@
 {{Portal-lat|Medicina|Hemija}}
 {{Commonscat-lat|Oxaprozin}}
-* [http://www.drugbank.ca/drugs/DB00991 Oxaprozin}-]
+* [http://www.drugbank.ca/drugs/DB00991 Oxaprozin]
 {{Medicinsko upozorenje-lat}}