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Mad About You centers on the trials and tribulations of a married couple living in New York.

Three twenty-somethings share a Boston apartment and hang around (and work) at a pizza place.

Marriage counselor Susan DeRuzza winds up sharing office space with divorce attorney Jack Harold and sparks fly.

Wall Street broker Carl loses everything, forced to live with brother Simon in Harlem. When Simon lands a high-paying TV job, Carl struggles with his sibling's success.

Jack's parents unexpectedly visit and tell him that they are getting divorced. Jack asks Susan to save their marriage.

It's Susan's birthday. She's turning 40 and insists that she's fine with her age. Jack offers himself as a gift but only until midnight. There is also the hot gardener.

Jamie tells Paul they should renew their wedding vows. Paul is not enthused about it. Paul has tonsillitis but Jamie thinks it is just a sore throat. Lisa is a mentor to a young teen. Mabel says her first word.

Jamie and Paul travel with Ira and Fran for the weekend in Atlantic City where Ira's long-estranged wife, Marianne, who works as the casino hostess, arranges their weekend for them. But Paul is not fond of the memories he has of Marianne who deserted Ira nearly 20 years ago, and who wants Ira to sign divorce papers for her to get married again.

Paul and Jamie finally admit they have no time to walk Murray so they hire Nat Ostertag, a dog walker.

Paul shows his Buchman documentary to a former professor. Nat's sister visits and gives astrological readings. Jamie's reading shows she is a liar. Nat quits because of the reading. Jamie finds out her birth date was wrong.

A review of Paul's documentary comes out. The review is positive, but the movie facts are wrong. Jamie starts a new job and misses Mabel. She wants the company to fire her so she tries to be annoying by getting constant interruptions.

Paul's father Burt has a small heart attack. While he is in the hospital, Paul & Jamie stay with his mother Sylvia. Sylvia manages to make her backhand compliments to Jamie and Paul's sister, while treating Paul still as a young child.

Jamie is dismayed to find her mother is dating, and the man is younger than her mother. Paul wants Jamie to start Mabel with bottle feeding so he could help feed Mabel. He points out all the times Jamie is late getting home to feed Mabel.

Paul, Ira, and Burt go to Burt's old building for part of the Buchman documentary. Paul runs late to hear the baby's heartbeat at Jamie's pregnancy checkup appointment.

It's Paul's birthday once again and he lives in fear when this day comes every year; Not because he's a year older. but as he says, something bad always happens to him. Over the last four years, from 1991-94, we receive a "sample" of Paul's past birthday misfortunes and see why this "haunts" him every year since he was a kid; From Jamie almost leaving him, to having a catered party being given to him and only two people being there due to a freak spring snowstorm to having a surprise party thrown for him and is on the brink of crashing, due to a combination of exhaustion and being given a sleeping pill accidentally by his sister-in-law Lisa. Now we are back to the present time (1995) and we find out that this year is no exception!!!

Paul and Jamie attend a party held by their therapist, Sheila. They meet another therapist there and relate more to him than Sheila, so they want to start going to him. Meanwhile, Burt & Sylvia have a spat, and Burt stays with Paul & Jamie.

Jamie tells Brockwell she is pregnant. Everyone starts treating her differently and she does not want that. She goes shopping for maternity clothes. Paul interviews narrators for the Buchman project, and Ira decides to become his producer.

While filming for the Buchman documentary, Paul's great Uncle Marty has a heart attack and dies, with the last words of his great regret - Who Moos. Paul tries to find out what it means. All the relatives have their own theory.

Paul & Jamie meet at Rockefeller Center ice rink on Valentines Day for an anniversary skate. They think back to three years previous when they searched for their first apartment and got engaged.

Paul and Jamie return home with their new baby. They experience new parent anxiety for taking care of the baby. Family members all try to help. They name her Mabel - Mothers Always Bring Extra Love.

Jamie becomes upset when Lisa comes into her own, under a pseudonym, as the "saddest chapter" in her therapist's book, which blames Jamie as the "overbearing" sister for all the problems in her life despite the fact that it's Lisa who is the overbearing and obnoxious type.

It's the first day of school and Jamie is reluctant about going, being the "new kid on the block", she's afraid that when she goes to the cafeteria, she will have her fish sticks and since she doesn't know anybody, she will eat alone and is using the excuse that Paul doesn't want her to go. Paul, along with Lisa Ira and Fran, throw a small surprise party that morning for Jamie's first day of school. Jamie is ready to go, and Paul finds an envelope containing her prepayment for tuition and registration that he forgot to mail. Paul finds out from the college, that he can pay the tuition today, so he decides to rush to the college with Ira and has Fran and Lisa stall Jamie. When Paul and Ira arrive at the college, they pay the tuition, but they find out that each course card must be signed by the department head. Paul enlists Ira, Fran and Lisa to go to the department heads; Paul for intermediate French, Lisa to logic, Fran for Psychology, Ira to Ethics as they all have to pose as Jamie and beg, bribe and outwit each department head for their signature and get Jamie registered, before she arrives.

Favors to each other abound with each one asking another one to complete a favor. Everything is complicated by Paul's fancy new camera.

Previously Paul & Jamie did a pregnancy test and it indicates YES. Jamie does not want them to tell anyone until they have the official news from the doctor. They avoid telling people while they search for a new gynecologist.

Paul and Jamie each have strange dreams with sexual undertones and bizarre happenings. They try to interpret them, but even the interpretations are bizarre.