- Contended with Cher for roles in films. Huston auditioned for the role of Alexandra Medford in The Witches of Eastwick (1987) but Cher won the part, and Huston was chosen over Cher for the roles of the Grand High Witch in The Witches (1990) and Morticia Addams in The Addams Family (1991).
- At the end of her 17 year relationship with Jack Nicholson, Nicholson gifted her a pearl and diamond bracelet which had once been a gift from Frank Sinatra to Ava Gardner. It was Nicholson's way of concluding their relationship. Huston appeared with Nicholson in five films: One Flew Over the Cuckoo's Nest (1975), The Last Tycoon (1976), The Postman Always Rings Twice (1981), Prizzi's Honor (1985) and The Crossing Guard (1995).
- Third generation in her family to receive the star on the Hollywood Walk of Fame, after her father, John Huston and grandfather, Walter Huston. (January 22, 2010)
- As a child she wanted to be a nun because the idea of wearing a veil was aesthetically pleasing to her.
- Her parents separated in the early 1960s and had children by other people: Danny Huston, her father's son with Zoe Sallis; and Allegra Huston, her mother's daughter with John Julius Norwich. Despite this, they never divorced.
- Cat lover -- during an appearance on The Rosie O'Donnell Show (1996), she divulged that she has eight outdoor cats and three indoor cats at her Venice, California home.
- While filming The Addams Family (1991) turned Raul Julia's frightening medical issue into a laughing matter after Julia's eyeball suddenly fell out of his head. Julia was able to go to set the next day despite his shocking injury. Huston pulled a prank on her beloved co-star; she bought out a novelty shop of fake dangling eyeballs. The next day, everyone on set had these fake eyeballs coming out of their head.
- John Steinbeck, a family friend, visited the Hustons in Ireland for Christmas one year and was appointed the role of Santa Claus for Anjelica and her brother, Tony.
- Andy Warhol captured her in one of his famous Polaroids.
- Survived a near-fatal car accident. She was driving down Coldwater Canyon at dusk when a BMW came very, very fast from up ahead and clipped the bumper of the car in front of her. Huston's face smashed into the windshield and she was admitted to Cedars-Sinai, where she had a long operation to remove bone shards from her forehead and skull, and reconstruct her nose. When she woke up Jack Nicholson was there with flowers. In interview, Huston shared that the accident was a life changing. (1980)
- Born while her father was in Africa shooting The African Queen (1951).
- It took eight hours of make up time to transform into "The Grand High Witch".
- Directed by eight Academy Award winners: Clint Eastwood, Woody Allen, James Ivory, Sean Penn, Francis Ford Coppola, Milos Forman and Tony Richardson.
- When Richard Avedon, a friend of Huston's parents, first shot her, he told Ricki (Anjelica's mother) that Anjelica's shoulders were too big for her to be a model. He'd later photograph her for Vogue.
- Offered the role of Annie Wilkes in the horror film Misery (1990) but turned it down because she was committed to the role of Lilly Dillon in The Grifters (1990). The role went to Kathy Bates. In 2013, Huston described the Lilly Dillon as the most challenging role of her career. The performance ranked #84 on Premiere magazine's 100 Greatest Performances of All Time (2006).
- Although the Grand High Witch is one of Huston's most memorable performances, Roald Dahl (author of the book) originally wanted Cher, but she was unavailable filming Mermaids (1990). Frances Conroy, Liza Minnelli, Eartha Kitt, Olivia Hussey, Geneviève Bujold, Sigourney Weaver, Starr Andreeff, Linda Blair, Fiona Fullerton, Faye Dunaway, Jodie Foster, and Vanessa Redgrave were all considered for the role before it went to Huston. Ultimately, Dahl was pleased with the outcome.
- To study the character Maerose Prizzi, to master the accent and characterization of a mafia daughter, she went to a Brooklyn church.
- Member of the jury at Cannes Film Festival. (1990)
- Her hair briefly caught fire when she was filming a scene for the The Royal Tenenbaums (2001).
- Member of the jury at the Venice Film Festival. (1996)
- Worked with Christina Ricci in four different films: The Addams Family (1991), Addams Family Values (1993), Bastard Out of Carolina (1996) (Huston's directorial debut), and Buffalo '66 (1998).
- In Blood Work (2002), she works with Clint Eastwood. In White Hunter Black Heart (1990), Eastwood plays a movie director based on her father, John Huston, in a story about his experiences making The African Queen (1951).
- In 1992, married famous sculptor Robert Graham. Warren Beatty and Annette Bening, Meryl Streep, Arnold Schwarzenegger, Joe Pesci, Carrie Fisher, Lauren Hutton, Harry Dean Stanton, Lauren Bacall, Carol Kane, Michelle Phillips, Mick Jagger and Penny Marshall attended their wedding. The wedding party included Jerry Hall and Joan Juliet Buck. Graham died in 2008. Sharon Stone and Harrison Ford attended the funeral.
- Third generation of Oscar winners in the her family, after her father, John Huston, and her grandfather, Walter Huston.
- Named after her biological maternal grandmother Angelica Soma, who died when Anjelica's mother Ricki was a child.
- Was to direct Million Dollar Baby (2004) but when producer Albert S. Ruddy acquired the 'Rope Burns' rights, Hustin was busy on another project and Clint Eastwood took the job.
- Her father, John Huston, directed The African Queen (1951) with Katharine Hepburn and played Gandalf in The Return of the King (1980). Anjelica herself later worked with her father's successor, Ian McKellen, in And the Band Played On (1993) and with Cate Blanchett, who appeared in the trilogy, as well as playing Hepburn in The Aviator (2004), in The Life Aquatic with Steve Zissou (2004). Also appearing in The Aviator (2004) was her brother, Danny Huston.
- Has worn the fragrance Jean Patou's "1000" since 1986.
- PETA awarded her 'Person of the Year', for her volunteer work with helping the great apes and appealing to the New York City Council in support of a bill that would phase out the city's archaic horse-drawn carriage industry. She also sent a letter to the Irish government urging the country to honor its commitment to banning fur farms. (2012)
- (March 25, 1991) Presented Myrna Loy with her honorary Oscar at the 63rd Academy Awards ceremony.
- Named one of Barbara Walters' Ten Most Fascinating People. (1991)
- Has stated that she was "desperate" to read for Franco Zeffirelli's Romeo and Juliet (1968), but her father had her cast in A Walk with Love and Death (1969)' instead.
- Auditioned for the role of Alexandra Medford in The Witches of Eastwick (1987), but Cher won the part.
- Turned down the role of Madison in Splash (1984), the role went to Daryl Hannah.
- Offered the role of Jennifer in Backdraft (1991), but she was committed to The Addams Family (1991). The role went to Jennifer Jason Leigh.
- Aunt of Jack Huston, Laura Huston, & Matthew Huston. Great aunt of Sage Lavinia Huston & Cypress Night Huston (born to Jack Huston and his wife, Victoria's Secret and Sports Illustrated model, Shannan Click.
- She appeared in five films directed by John Huston: Casino Royale (1967), A Walk with Love and Death (1969), Sinful Davey (1969), Prizzi's Honor (1985) and The Dead (1987).
- Was considered for the role of "Catherine Tramell" in Basic Instinct (1992), which went to Sharon Stone.
- Jena Malone made her film debut in Huston's directorial debut Bastard Out of Carolina (1996).
- (March 24, 1986) 31st actress to receive the Academy Award for Best Supporting Actress. She won the Best Supporting Actress Oscar for Prizzi's Honor (1985) at The 58th Annual Academy Awards (1986). Marsha Mason and Richard Dreyfuss presented her with the Oscar. After her speech, she exited the stage back into the audience to be her father, seated in the middle of the center row, with tears down his cheeks. Tzetzi Ganev designed her Oscar dress, a green silk, in honor of her Irish upbringing.
- She and Alicia Silverstone were originally cast in the film Heartbreakers (2001). For unknown reasons, they were replaced by Sigourney Weaver and Jennifer Love Hewitt.
- launched The Huston School of Film and Digital Media at NUI Galway. (2013)
- Became Marianne Faithfull's understudy after losing the role of Ophelia to her for a production of Hamlet. Later, after Huston's mother's fatal car crash, Faithfull gave her a "long red fox coat" and drove her to the pharmacy.
- She and legendary writer Joan Juliet Buck have been close friends since childhood.
- Wanted Rosie O'Donnell to play the title part in Agnes Browne (1999) (Huston's second directorial), but after O'Donnell turned it down, Huston decided to play the part. O'Donnell would later star opposite Andie MacDowell in Huston's third directorial, the made-for-TV film, Riding the Bus with My Sister (2005).
- Lived with photographer Bob Richardson (Terry Richardson's dad) from 1969 to 1973. When they started their relationship, he was 41 and she was not yet 18.
- Appeared in Lonesome Dove (1989) as Clara. Two other actresses have played that character in her younger years: Jennifer Garner and Linda Cardellini. All three of them, however, have a connection to the role of the Joker from Batman. Huston had a long-term relationship with Jack Nicholson, who played the role in Batman (1989). Garner was married to Ben Affleck, and had appeared in Dallas Buyers Club (2013) with Jared Leto. Cardelini appeared in Brokeback Mountain (2005) with Heath Ledger.
- Offered but declined the role of the female lead in Mac and Me (1988).
- Contrary to what many people assume, her childfree status is not voluntary. In a 1998 Lifetime Intimate Portrait (1990) episode, she said that she's tried to have a baby on several occasions. Elaborating on the subject, Huston wrote in her autobiographies that she failed to conceive with husband Robert Graham as well as former boyfriends Bob Richardson and Jack Nicholson. She started trying to get pregnant with Richardson when she was still in her teens, and kept trying, on and off, until her mid-40s, even undergoing in-vitro fertilization.
- Revealed in her memoir "Watch Me" (2014) that she had an affair during the shooting of Ever After: A Cinderella Story (1998), with a married man known simply as Dolyn in the book.
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