- She was the original choice for the title role in Xena: Warrior Princess (1995). Due to an illness, she was not able to fly to New Zealand to start work in the role of "Xena". A replacement had to be found quickly in New Zealand and so Lucy Lawless, who was already there, was cast.
- She was introduced to her future husband Rick Otto by her Weird Science (1994) co-star Lee Tergesen.
- Started a clothing line in 2009, VANE la, which sells in top boutiques in Los Angeles, including Ron Herman and Belle Gray. She designs 1970s-inspired dresses and tops in silk, vintage prints.
- Vanessa and her ex-husband Rick Otto have a daughter named India Otto (DOB: March 10, 2001) who played women's basketball for the University of Southern California.
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