- She always does her own German, French, and English voice dubbing for the foreign releases of her films.
- She is fluent in German, English, and French. Additionally, she studied Latin for eight years in school, and learned Russian for the film The Tiger Brigades (2006).
- While filming Frankie (2005), she would live in an actual mental hospital where the film was shot with members of the crew in order to shoot scenes.
- Was a professional model under her birth name, Diane Heidkrüger, from 1992 to 1997.
- In a relationship with Norman Reedus since 2016. They have a daughter together, Nova Tennessee (b. November 2018).
- Was considered too thin for the role of Helen of Troy in Wolfgang Petersen's film Troy (2004) and had to gain 15 lbs. in order to appear rounder.
- Began training at the Royal Ballet School in London during her summer breaks from school when she was 11 with aspirations of becoming a professional ballerina. However, when she was 13 she suffered a knee injury that required two metal plates to be inserted, effectively ending her dreams.
- Was in a long-term relationship with Joshua Jackson from 2006 until 2016.
- Has stated that she has a deathly fear of horses and will not star in any movies that requires her riding a horse.
- Studied acting at the Cours Florent, a prestigious drama school in Paris, France. She won the Classe Libre award as the best actor in her year.
- Was made an Officer in the Order of Arts and Letters (Ordre des Arts et des Lettres), a French Order of Merit, for her contributions to French cinema in 2014.
- Member of the jury at the 58th Berlin Film Festival in 2008. She was a member of the jury for the main competition at the 65th Cannes Film Festival in 2012, and at the 72nd Venice International Film Festival in 2015.
- In August 2021, Kruger announced her engagement to actor Norman Reedus.
- Was the hostess (maitresse de cérèmonie) of the 60th Cannes Film Festival in 2007. She was the first German to host the film festival.
- Is an active supporter of the United Nations Children's Fund (UNICEF).
- Named the "Sexiest International Import" on Victoria's Secret's "What Is Sexy" list in 2012.
- Parents are Hans-Heinrich, and computer specialist, and Maria-Theresa Heidkrüger, a bank employee. Her father left the family, and her parents divorced when she was 13.
- Stated that she dreamed about having a career like Romy Schneider's - an Austrian-German actress who had a successful career in France, had a relationship with a French actor and made Hollywood films.
- Was a finalist in the famous Elite Model Look contest the same year as former First Lady of the United States Melania Trump.
- Is very good friends with ex-husband Guillaume Canet.
- Attended the Episcopal Gymnasium Josephinum, a Catholic high school in Hildesheim, Lower Saxony, German, through the tenth grade.
- Represented Germany in Elite Model Management's "Look of the Year" competition in 1992, at the age of 16.
- People magazine included Diane in its annual "50 Most Beautiful People in the World" issue in 2004.
- She has a younger brother, Stefan.
- Ranked #83 on AskMen's "Top 99 Women" list in 2010.
- Ranked #88 on Maxim's "Hot 100" list in 2009.
- Ranked #50 on Maxim's "Hot 100" list in 2005.
- Born at 12:00 PM (MET).
- Born on the same date as Gabriel Iglesias.
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