Even though this has been the most watched show on Channel 4, it has never won a major television award since it has been on the air.
In May 2005, Richard Whiteley caught pneumonia, and his position as host was to be temporarily filled by a series of guest presenters during the recording of Series 54. He later died in June, and after auditions for a new host the show returned in October hosted by Des Lynam. The guest-presented episodes were never aired, and a new Series 54 was recorded instead. Others who auditioned included Richard Digance and Noel Edmonds; Paul Merton was also rumored to have been under consideration.
This was the first program broadcast on Channel Four, the UK's fourth television network.
The last Conundrum ever solved in Carol Vorderman's last episode was ERACLOSES, which meant that it was her last episode with Des O'Connor.