A house is constantly shown to the left, across the street (the Donahue's house) from the Hecks' home. This is the set house used in Ma sorcière bien aimée (1964). To the right of the Hecks' home is the house used for The Partridge Family (1970) .
The fountain that appears in a few episodes is the fountain from the opening credits of Friends.
The original pilot episode starred Ricki Lake as Frankie Heck. Most of the cast was replaced after that production, with Atticus Shaffer (Brick) being the only actor remaining.
The town of Orson, Indiana, is fictional, but based on the real-life Indiana town of Jasper.
The character Brick, played by Atticus Shaffer, is rumored to have Asperger syndrome or some sort of autism. He also possesses eidetic memory. The actor has osteogenesis imperfecta type 4 which causes him to break his bones easily.