Director Fede Alvarez sought out the special effects crew from Aliens (1986) to work on the creatures. Physical sets, practical creatures, and miniatures were used wherever possible to help ground later VFX work.
Cailee Spaeny said this film takes place between Alien (1979) and Aliens (1986). It takes place in the year 2142, exactly 20 years after Alien (situated in 2122) and 37 years before Aliens (2179).
The film's production design draws not only on the previous films in the series, but also the Alien: Isolation (2014) video game, including the "Emergency" communication stations which served as save points in the game. Fede Alvarez played the game around the time Don't Breathe (2016) was released, and later said, "I was playing, and realizing how terrifying Alien could be if you take it back to that tone."
The fictional chronology of all the films in the Alien franchise is as follows:
- Prometheus (2012) takes place in 2093.
- Alien: Covenant (2017) takes place in 2104.
- Alien (1979) takes place in 2122.
- Alien: Romulus (2024) takes place in 2142.
- Aliens (1986) takes place in 2179.
- Alien³ (1992) takes place in 2179.
- Alien Resurrection (1997) takes place in 2381.
The film was shot chronologically.