Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

026148-68-5
000083-32-9
025732-74-5
000075-07-0
000075-07-0

A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole)
Acenaphthene
Acepyrene (3,4-dihydrocyclopenta[cd]pyrene)
Acetaldehyde
Acetaldehyde associated with consumption of alcoholic
beverages
Acetamide
Acetaminophen (see Paracetamol)
Acheson process, occupational exposure associated with
Aciclovir
Acid mists, strong inorganic
Acridine orange
Acriflavinium chloride
Acrolein
Acrylamide
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Acrylic acid
Acrylic fibres
Acrylonitrile
Acrylonitrile-butadiene-styrene copolymers
Actinomycin D
Adriamycin
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
AF-2 [2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide]
Aflatoxins

000060-35-5
000103-90-2
059277-89-3
000494-38-2
008018-07-3
000107-02-8
000079-06-1

000079-10-7
000107-13-1
000050-76-0
023214-92-8

003688-53-7
001402-68-2

Group

006795-23-9 Aflatoxin M1
002757-90-6 Agaritine
Alcoholic beverages
000116-06-3 Aldicarb
000309-00-2 Aldrin
Aloe vera, whole leaf extract
000107-05-1 Allyl chloride
000057-06-7 Allyl isothiocyanate
002835-39-4 Allyl isovalerate
Alpha particles (see Radionuclides)
Aluminium production

Year

2B
3
3
2B
1

40, Sup 7
92
92
36, Sup 7, 71
100E

1987
2010
2010
1999
2012

2B

7, Sup 7, 71

1999

1
3
1
3
3
3
2A

111
76
54, 100F
16, Sup 7
13, Sup 7
63, Sup 7
60, Sup 7

3
3
2B
3
3
2A

19, Sup 7, 71
19, Sup 7
71
19, Sup 7
10, Sup 7
10, Sup 7

1999
1987
1999
1987
1987
1987

2B
1

31, Sup 7
56, 82, 100F,
Sup 7
56
31, Sup 7
44, 96, 100E
53
5, Sup 7
108
36, Sup 7, 71
73, Sup 7
36, Sup 7, 71

1987
2012

2B
3
1
3
3
2B
3
3
3
1

Volume

34, Sup 7,
92, 100F

In prep
2000
2012
1987
1987
1995
1994

1993
1987
2012
1991
1987
in prep
1999
1999
1999
2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

000915-67-3
004657-93-6
000117-79-3
000060-09-3
000097-56-3
000150-13-0
000092-67-1

Amaranth
5-Aminoacenaphthene
2-Aminoanthraquinone
para-Aminoazobenzene
ortho-Aminoazotoluene
para-Aminobenzoic acid
4-Aminobiphenyl

3
3
3
2B
2B
3
1

000081-49-2
000082-28-0
000712-68-5
000099-57-0
000121-88-0
000119-34-6
000121-66-4
002432-99-7
000061-82-5

1-Amino-2,4-dibromoanthraquinone
1-Amino-2-methylanthraquinone
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
2-Amino-4-nitrophenol
2-Amino-5-nitrophenol
4-Amino-2-nitrophenol
2-Amino-5-nitrothiazole
11-Aminoundecanoic acid
Amitrole
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
Ampicillin
Amsacrine
Androgenic (anabolic) steroids
Anaesthetics, volatile
Angelicin plus ultraviolet A radiation
Aniline
ortho-Anisidine
para-Anisidine
Anthanthrene
Anthracene
Anthranilic acid
Anthraquinone
Antimony trioxide
Antimony trisulfide
Apholate
para-Aramid fibrils
Aramite
Areca nut

000069-53-4
051264-14-3

000523-50-2
000062-53-3
000090-04-0
000104-94-9
000191-26-4
000120-12-7
000118-92-3
000084-65-1
001309-64-4
001345-04-6
000052-46-0
024938-64-5
000140-57-8

Group

Volume

Year

2B
3
2B
3
3
3
3
3
3

8, Sup 7
16, Sup 7
27, Sup 7
8, Sup 7
8, Sup 7
16, Sup 7
1, Sup 7, 99,
100F
101
27, Sup 7
7, Sup 7
57
57
16, Sup 7
31, Sup 7
39, Sup 7
79, Sup 7

1987
1987
1987
1987
1987
1987
2012
2013
1987
1987
1993
1993
1987
1987
1987
2001

3
2B
2A
3
3
3
2B
3
3
3
3
2B
2B
3
3
3
2B
1

50
76
Sup 7
11, Sup 7
40, Sup 7
27, Sup 7
Sup 7, 73
27, Sup 7
92, Sup 7
92, Sup 7
16, Sup 7
101
47
47
9, Sup 7
68
5, Sup 7
85, 100E

1990
2000
1987
1987
1987
1987
1999
1987
2010
2010
1987
2013
1989
1989
1987
1997
1987
2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000313-67-7 Aristolochic acid

(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
000313-67-7 Aristolochic acid, plants containing
007440-38-2 Arsenic and inorganic arsenic compounds
064436-13-1 Arsenobetaine and other organic arsenic compounds that
are not metabolized in humans
Art glass, glass containers and pressed ware
(manufacture of)
001332-21-4 Asbestos (all forms, including actinolite, amosite,
013768-00-8 anthophyllite, chrysotile, crocidolite, tremolite)
(NB: Mineral substances (e.g. talc or vermiculite) that
012172-73-5
contain asbestos should also be regarded as
017068-78-9 carcinogenic to humans.)
012001-29-5
012001-28-4
014567-73-8
001912-24-9 Atrazine
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
012174-11-7 Attapulgite (see Palygorskite)
000492-80-8 Auramine
Auramine production

000151-56-4 Aziridine
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
001072-52-2 2-(1-Aziridinyl)ethanol
000800-24-8 Aziridyl benzoquinone
000103-33-3 Azobenzene
000202-94-8 11H-Benz[bc]aceanthrylene
000202-33-5 Benz[j]aceanthrylene
(NB: Overall evaluation upgraded to Group 2B with
supporting mechanistic and other relevant data)

Year

82, 100A

2012

1
1

82, 100A
23, Sup 7,
100C
100C

2012
2012

58

1993

14, Sup 7,
100C

2012

53, 73

1999

1, Sup 7, 99,
100F
Sup 7, 99,
100F
13, Sup 7
50

2012

3
2A

2B
1

012192-57-3 Aurothioglucose
000320-67-2 Azacitidine
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000115-02-6 Azaserine
000446-86-6 Azathioprine

Volume

3
2A

2B
1

2012

2012
1987
1990

1987
2012

2B

10, Sup 7
26, Sup 7,
100A
9, Sup 7, 71

3
3
3
3
2B

9, Sup 7
9, Sup 7
8, Sup 7
92
92

1987
1987
1987
2010
2010

1999

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000211-91-6 Benz[l]aceanthrylene
000225-11-6 Benz[a]acridine

3
3

000225-51-4 Benz[c]acridine

000056-55-3 Benz[a]anthracene
000071-43-2 Benzene

000214-17-5
000196-78-1
000203-33-8
000205-99-2
000203-12-3
000205-82-3
000207-08-9
000238-84-6
000243-17-4
000205-12-9
000271-89-6
000239-35-0
000191-24-2
000195-19-7

000119-61-9
000050-32-8

000192-97-2
000105-11-3
000094-36-0
000140-11-4
001694-09-3
007440-41-7

2010
2013

3
3
3
2B
3
2B
2B
3
3
3
2B
3
3
2B

92
92
92, Sup 7
92
92, Sup 7
92
92
92, Sup 7
92, Sup 7
92, Sup 7
63
103
92, Sup 7
92, Sup 7

2010
2010
2010
2010
2010
2010
2010
2010
2010
2010
1995
2013
2010
2010

2B
1

101
Sup 7, 92,
100F

2013
2012

3
3
3
3
2B
1

92, Sup 7
29, Sup 7, 71
36, Sup 7, 71
40, Sup 7, 71
16, Sup 7
Sup 7, 58,
100C

2010
1999
1999
1999
1987
2012

Benzidine, dyes metabolized to

(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
Benzo[b]chrysene
Benzo[g]chrysene
Benzo[a]fluoranthene
Benzo[b]fluoranthene
Benzo[ghi]fluoranthene
Benzo[j]fluoranthene
Benzo[k]fluoranthene
Benzo[a]fluorene
Benzo[b]fluorene
Benzo[c]fluorene
Benzofuran
Benzo[b]naphtho[2,1-d]thiophene
Benzo[ghi]perylene
Benzo[c]phenanthrene
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
Benzophenone
Benzo[a]pyrene
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
Benzo[e]pyrene
para-Benzoquinone dioxime
Benzoyl peroxide
Benzyl acetate
Benzyl violet 4B
Beryllium and beryllium compounds
Beta particles (see Radionuclides)

Year

92
32, Sup 7,
103
32, Sup 7,
103
92, Sup 7
29, Sup 7.
100F
29, Sup 7,
99, 100F
99, 100F

2B
1

000092-87-5 Benzidine

Volume

2013
2010
2012
2012
2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

002168-68-5
003296-90-0
000111-44-4
000494-03-1

Agent

Group

Betel quid with tobacco

Betel quid without tobacco

Biomass fuel (primarily wood), indoor emissions from

household combustion of
Bis(1-aziridinyl)morpholinophosphine sulfide
2,2-Bis(bromomethyl)propane-1,3-diol
Bis(2-chloroethyl)ether
N,N-Bis(2-chloroethyl)-2-naphthylamine (see
Chlornaphazine)
Bischloroethyl nitrosourea (BCNU)
1,2-Bis(chloromethoxy)ethane
1,4-Bis(chloromethoxymethyl)benzene
Bis(chloromethyl)ether; chloromethyl methyl ether
(technical-grade)

000154-93-8
013483-18-6
056894-91-8
000542-88-1
000107-30-2
000108-60-1 Bis(2-chloro-1-methylethyl)ether
002386-90-5 Bis(2,3-epoxycyclopentyl)ether
000117-81-7 Bis(2-ethylhexyl) phthalate (see Di(2-ethylhexyl)
phthalate)
001675-54-3 Bisphenol A diglycidyl ether (Araldite)
Bisulfites
008052-42-4 Bitumens, extracts of steam-refined and air-refined;
steam-refined, cracking-residue and air-refined
bitumens
(see Bitumens, occupational exposures)
Bitumens, occupational exposure to hard bitumens and
their emissions during mastic asphalt work
064742-93-4 Bitumens, occupational exposure to oxidized bitumens
and their emissions during roofing
008052-42-4 Bitumens, occupational exposure to straight-run bitumens
064741-56-6 and their emissions during road paving
BK polyomavirus (BKV)
011056-06-7 Bleomycins
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
000129-17-9 Blue VRS
Boot and shoe manufacture and repair (see Leather dust,
Benzene)
Bracken fern
003844-45-9 Brilliant Blue FCF, disodium salt

Volume

Year

2A

Sup 7, 85,
100E
Sup 7, 85,
100E
95

2012

2010

3
2B
3

9, Sup 7
77
9, Sup 7, 71

1987
2000
1999

2A
3
3
1

26, Sup 7
15; Sup 7, 71
15; Sup 7, 71
4, Sup 7,
100F

1987
1999
1999
2012

3
3

41, Sup 7, 71
47, 71

1999
1999

3
3

47, 71
54
35, Sup 7

1999
1992
1987

2B

103

2013

2A

103

2013

2B

103

2013

2B
2B

104
26, Sup 7

2013
1987

16, Sup 7
25, Sup 7

1987
1987

2B
3

40, Sup 7
16, Sup 7

1987
1987

2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

005589-96-8
083463-62-1
000075-27-4
000074-96-4
000075-25-2
000055-98-1

Bromochloroacetic acid
Bromochloroacetonitrile
Bromodichloromethane
Bromoethane
Bromoform
Busulfan

Group
2B
3
2B
3
3
1

000106-99-0 1,3-Butadiene
000055-98-1
000111-76-2
057018-52-7
000141-32-2
025013-16-5
000128-37-0
000085-68-7
003068-88-0
000096-48-0
007440-43-9
000331-39-5
000058-08-2
000056-25-7
000105-60-2
002425-06-1

000133-06-2
000063-25-2
000086-74-8

020073-24-9 3-Carbethoxypsoralen
001333-86-4 Carbon black
Carbon electrode manufacture
308068-56-6 Carbon nanotubes, multi-walled MWCNT-7
308068-56-6 Carbon nanotubes, multi-walled, other than MWCNT-7
308068-56-6 Carbon nanotubes, single-walled
000056-23-5 Carbon tetrachloride
003567-69-9 Carmoisine

Year

101
52, 71
52, 71
52, 71
52, 71
4, Sup 7,
100A
Sup 7, 54,
71, 97, 100F

2013
1999
1999
1999
1999
2012

3
3
3
2B
3
3
2B
3
1
2B
3
3
3
4
2A

88
88
39, Sup 7, 71
40, Sup 7
40, Sup 7
Sup 7, 73
11, Sup 7, 71
11, Sup 7, 71
58, 100C
56
51
92
10, Sup 7
39, Sup 7, 71
53

2006
2006
1999
1987
1987
1999
1999
1999
2012
1993
1991
2010
1987
1999
1991

3
3
2B

30, Sup 7
12, Sup 7
32, Sup 7,
71, 103
40, Sup 7
Sup 7, 65, 93
92
111
111
111
20, Sup 7, 71
8, Sup 7

1987
1987
2013

1,4-Butanediol dimethanesulfonate (see Busulfan)

2-Butoxyethanol
1-tert-Butoxypropan-2-ol
n-Butyl acrylate
Butylated hydroxyanisole (BHA)
Butylated hydroxytoluene (BHT)
Butyl benzyl phthalate
beta-Butyrolactone
gamma-Butyrolactone
Cadmium and cadmium compounds
Caffeic acid
Caffeine
Calcium carbide production
Cantharidin
Caprolactam
Captafol
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Captan
Carbaryl
Carbazole

Volume

3
2B
2A
2B
3
3
2B
3

2012

1987
2010
2010
In prep
In prep
In prep
1999
1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

053973-98-1
009000-07-1
000120-80-9
000075-87-6
000302-17-0
000305-03-3

Agent

Group

Carpentry and joinery

Carrageenan, degraded (Poligeenan)
Carrageenan, native
Catechol
Chimney sweeping (see Soot)
Chloral
Chloral hydrate
Chlorambucil

2B
2B
3
2B

000107-14-2
000106-47-8
000510-15-6
000124-48-1
077439-76-0
000075-45-6
000075-00-3
013010-47-4

Chloroacetonitrile
para-Chloroaniline
Chlorobenzilate
Chlorodibromomethane
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
Chlorodifluoromethane
Chloroethane
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
013909-09-6 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
(see Methyl-CCNU)
000593-70-4 Chlorofluoromethane
000067-66-3 Chloroform

Year
1987
1987
1987
1999
2010
2014
2014
2012

3
2A

25, Sup 7
31, Sup 7
31, Sup 7
15, Sup 7, 71
92
63, 84, 106
63, 84, 106
26, Sup 7,
100A
84
Sup 7, 50

2B
2B
3
2B
3
2B

Sup 7, 53, 79
20, Sup 7
30, Sup 7
48
52
48

2001
1987
1987
1990
1991
1990

2A

29, Sup 7, 71

1999

2012

3
2B
3
3
2B
3
3
2A

4, Sup 7,
100A
52, 71
57
30, Sup 7
52, 71
84
41, Sup 7, 71
52, 71
26, Sup 7

1999
1993
1987
1999
2004
1999
1999
1987

3
2B

41, Sup 7, 71
Sup 7, 73

1999
1999

2A
2A
1

010599-90-3 Chloramine
000056-75-7 Chloramphenicol
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000057-74-9 Chlordane
000143-50-0 Chlordecone (Kepone)
006164-98-3 Chlordimeform
000115-28-6 Chlorendic acid
Chlorinated drinking-water
Chlorinated paraffins of average carbon chain length C12
and average degree of chlorination approximately 60%
000098-87-3 alpha-Chlorinated toluenes (benzal chloride,
000098-07-7 benzotrichloride, benzyl chloride) and benzoyl chloride
(combined exposures)
000100-44-7
000098-88-4
000494-03-1 Chlornaphazine

Volume

2004
1990

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000107-30-2 Chloromethyl methyl ether (see Bis(chloromethyl)ether;

chloromethyl methyl ether)
000513-37-1 1-Chloro-2-methylpropene
000563-47-3 3-Chloro-2-methylpropene
000088-73-3 Chloronitrobenzenes
000121-73-3
000100-00-5
Chlorophenols (see Polychlorophenols)
Chlorophenoxy herbicides
005131-60-2 4-Chloro-meta-phenylenediamine
000095-83-0 4-Chloro-ortho-phenylenediamine
000126-99-8 Chloroprene
000101-21-3 Chloropropham
000054-05-7 Chloroquine
001897-45-6 Chlorothalonil
000095-69-2 4-Chloro-ortho-toluidine
000095-79-4 5-Chloro-ortho-toluidine
000075-88-7 2-Chloro-1,1,1-trifluoroethane
054749-90-5 Chlorozotocin
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000057-88-5 Cholesterol
007440-47-3 Chromium, metallic
016065-83-1 Chromium (III) compounds
018540-29-9 Chromium (VI) compounds
000218-01-9
000532-82-1
006373-74-6
000523-44-4
006459-94-5
000569-61-9
001937-37-7
002602-46-2
002429-74-5
016071-86-6
001936-15-8
002425-85-6
059865-13-3

Chrysene
Chrysoidine
CI Acid Orange 3
CI Acid Orange 20
CI Acid Red 114
CI Basic Red 9
CI Direct Black 38 (see Benzidine, dyes metabolized to)
CI Direct Blue 6 (see Benzidine, dyes metabolized to)
CI Direct Blue 15
CI Direct Brown 95 (see Benzidine, dyes metabolized to)
CI Orange G
CI Pigment Red 3
Ciclosporin

Volume

Year

2B
3
3

63
63
65

1995
1995
1996

2B
3
2B
2B
3
3
2B
2A
3
3
2A

41, Sup 7
27, Sup 7
27, Sup 7
Sup 7, 71
12, Sup 7
13, Sup 7
Sup 7, 73
77, 99
77, 99
41, Sup 7, 71
50

1987
1987
1987
1999
1987
1987
1999
2010
2010
1999
1990

1987
1990
1990
2012

2B
3
3
3
2B
2B

31, Sup 7
Sup 7, 49
49
Sup 7, 49,
100C
92
8, Sup 7
57
8, Sup 7
57
57, 99

2010
1987
1993
1987
1993
2010

2B

57

1993

8, Sup 7
57
50, 100A

1987
1993
2012

3
3
3
1

3
3
1

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

051481-61-9 Cimetidine
000087-29-6 Cinnamyl anthranilate
015663-27-1 Cisplatin
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000518-75-2 Citrinin
006358-53-8 Citrus Red No. 2
000637-07-0 Clofibrate
000050-41-9 Clomiphene citrate
Clonorchis sinensis (infection with)
Coal, indoor emissions from household combustion of
Coal dust
Coal gasification
008007-45-2 Coal tars (see Coal-tar distillation)
008007-45-2 Coal-tar distillation
065996-93-2 Coal-tar pitch

010380-28-6
000191-07-1
000091-64-5
008001-58-9
000102-50-1
000120-71-8
004170-30-3

Continuous glass filament (see Glass filament)

Copper 8-hydroxyquinoline
Coronene
Coumarin
Creosotes
meta-Cresidine
para-Cresidine
Crotonaldehyde

Year

3
3
2A

50
Sup 7, 77
26, Sup 7

1990
2000
1987

3
2B
3
3
1
1
3
1

1987
1987
1996
1987
2012
2012
1997
2012

2B

40, Sup 7
8, Sup 7
Sup 7, 66
21, Sup 7
61, 100B
95, 100E
68
Sup 7, 92,
100F
35, Sup 7
92, 100F
35, Sup 7,
100F
52

2A

86

2006

2B
2B
2B
2B

86
86
101
51

2006
2006
2013
1991

Sup 7, 92,
100F

2012

15, Sup 7
32, Sup 7, 92
Sup 7, 77
Sup 7, 92
27, Sup 7
27, Sup 7
63

1987
1987
2000
2010
1987
1987
1995

1
1

007440-48-4 Cobalt and cobalt compounds

(NB: Evaluated as a group)
007440-48-4 Cobalt metal with tungsten carbide
012070-12-1
007440-48-4 Cobalt metal without tungsten carbide
010026-24-1 Cobalt sulfate and other soluble cobalt(II) salts
068603-42-9 Coconut oil diethanolamine condensate
Coffee (urinary bladder)
(NB: There is some evidence of an inverse relationship
between coffee drinking and cancer of the large bowel;
coffee drinking could not be classified as to its
carcinogenicity to other organs)
Coke production

Volume

3
3
3
2A
3
2B
3

1987
2012
2012
1991

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

008002-05-9
000098-82-8
014901-08-7
000139-05-9
012663-46-6
000108-94-1
000202-98-2
027208-37-3

Crude oil
Cumene
Cycasin
Cyclamates (sodium cyclamate)
Cyclochlorotine
Cyclohexanone
4H-Cyclopenta[def]chrysene
Cyclopenta[cd]pyrene
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
007099-43-6 5,6-Cyclopenteno-1,2-benzanthracene
000050-18-0 Cyclophosphamide
006055-19-2
059865-13-3 Cyclosporine (see ciclosporin)
079217-60-0
004342-03-4 Dacarbazine
005160-02-1 D & C Red No. 9
000117-10-2 Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)
000080-08-0 Dapsone
020830-81-3 Daunomycin
000050-29-3 DDT (4,4'-Dichlorodiphenyltrichloroethane)
001163-19-5 Decabromodiphenyl oxide
052918-63-5 Deltamethrin
000083-63-6 Diacetylaminoazotoluene
000613-35-4 N,N'-Diacetylbenzidine
002303-16-4 Diallate
000615-05-4 2,4-Diaminoanisole
000101-80-4 4,4'-Diaminodiphenyl ether
000099-56-9 1,2-Diamino-4-nitrobenzene
005307-14-2 1,4-Diamino-2-nitrobenzene
000095-80-7 2,4-Diaminotoluene
000095-70-5 2,5-Diaminotoluene
000439-14-5 Diazepam
333-41-5 Diazinon
000334-88-3 Diazomethane
000226-36-8 Dibenz[a,h]acridine

10

Volume

Year

3
2B
2B
3
3
3
3
2A

45
101
10, Sup 7
Sup 7, 73
10, Sup 7
47, 71
92
Sup 7, 92

1989
2013
1987
1999
1987
1999
2010
2010

3
1

92
26, Sup 7,
100A

2010
2012

2B
3
2B
3
2B
2B
3
3
3
2B
3
2B
2B
3
3
2B
3
3
2A
3
2B

26, Sup 7
Sup 7, 57
50
24, Sup 7
10, Sup 7
Sup 7, 53
48, 71
53
8, Sup 7
16, Sup 7
30, Sup 7
Sup 7, 79
29, Sup 7
16, Sup 7
Sup 7, 57
16, Sup 7
16, Sup 7
Sup 7, 66
112
7, Sup 7
32, Sup 7,
103

1987
1993
1990
1987
1987
1991
1999
1991
1987
1987
1987
2001
1987
1987
1993
1987
1987
1996
in prep
1987
2013

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000224-42-0 Dibenz[a,j]acridine
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000224-53-3 Dibenz[c,h]acridine
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
000215-58-7 Dibenz[a,c]anthracene
000053-70-3 Dibenz[a,h]anthracene
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000224-41-9 Dibenz[a,j]anthracene
000194-59-2 7H-Dibenzo[c,g]carbazole
000262-12-4
005385-75-1
000207-83-0
000192-47-2
000192-65-4
000189-64-0
000189-55-9
000191-30-0

000192-51-8
000132-65-0
000631-64-1
003252-43-5
000096-12-8
000096-13-9
000079-43-6
003018-12-0
007572-29-4
000541-73-1
000095-50-1
000106-46-7
000091-94-1
000110-57-6
028434-86-8
000107-06-2

Dibenzo-para-dioxin
Dibenzo[a,e]fluoranthene
13H-Dibenzo[a,g]fluorene
Dibenzo[h,rst]pentaphene
Dibenzo[a,e]pyrene
Dibenzo[a,h]pyrene
Dibenzo[a,i]pyrene
Dibenzo[a,l]pyrene
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Dibenzo[e,l]pyrene
Dibenzothiophene
Dibromoacetic acid
Dibromoacetonitrile
1,2-Dibromo-3-chloropropane
2,3-Dibromopropan-1-ol
Dichloroacetic acid
Dichloroacetonitrile
Dichloroacetylene
meta-Dichlorobenzene
ortho-Dichlorobenzene
para-Dichlorobenzene
3,3'-Dichlorobenzidine
trans-1,4-Dichlorobutene
3,3'-Dichloro-4,4'-diaminodiphenyl ether
1,2-Dichloroethane

11

Volume

Year

2A

32, Sup 7,
103

2013

2B

103

2013

3
2A

Sup 7, 92
Sup 7, 92

2010
2010

3
2B

2010
2013

3
3
3
3
3
2B
2B
2A

Sup 7, 92
32, Sup 7,
103
69
Sup 7, 92
92
Sup 7, 92
Sup 7, 92
Sup 7, 92
92
Sup 7, 92

1997
2010
2010
2010
2010
2010
2010
2010

3
3
2B
2B
2B
2B
2B
3
3
3
3
2B
2B
3
2B
2B

92
103
101
52, 71, 101
20, Sup 7, 71
77
63, 84, 106
52, 71
39, Sup 7, 71
73
Sup 7, 73
Sup 7, 73
29, Sup 7
15, Sup 7, 71
16, Sup 7
20, Sup 7, 71

2010
2013
2013
2013
1999
2000
2014
1999
1999
1999
1999
1999
1987
1999
1987
1999

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000075-09-2 Dichloromethane (Methylene chloride)

000609-20-1 2,6-Dichloro-para-phenylenediamine
000078-87-5 1,2-Dichloropropane

2A
3
1

000096-23-1
000542-75-6
000062-73-7
000115-32-2
069655-05-6
000060-57-1
001464-53-5

1,3-Dichloro-2-propanol
1,3-Dichloropropene (technical-grade)
Dichlorvos
Dicofol
Didanosine
Dieldrin
1,2:3,4-Diepoxybutane (see Monographs on 1,3Butadiene)
Diesel engine exhaust (see Engine exhaust, diesel)
Diesel fuels, distillate (light)
Diesel fuel, marine
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
000111-42-2 Diethanolamine
000103-23-1 Di(2-ethylhexyl) adipate
000117-81-7 Di(2-ethylhexyl)phthalate

2B
2B
2B
3
3
3

001615-80-1 1,2-Diethylhydrazine
000056-53-1 Diethylstilbestrol

2B
1

000064-67-5 Diethyl sulfate

(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000105-55-5 N,N'-Diethylthiourea
000101-90-6 Diglycidyl resorcinol ether
020830-75-5 Digoxin
000641-48-5 Dihydroaceanthrylene
000094-58-6 Dihydrosafrole
000794-93-4 Dihydroxymethylfuratrizine (see also Panfuran S)
002973-10-6 Diisopropyl sulfate
000828-00-2 Dimethoxane
000119-90-4 3,3'-Dimethoxybenzidine (ortho-Dianisidine)
000091-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate
000060-11-7 para-Dimethylaminoazobenzene
000140-56-7 para-Dimethylaminoazobenzenediazo sodium sulfonate

12

Volume

Year

Sup 7, 71,
110
39, Sup 7
41, Sup 7,
71, 110
101
41, Sup 7, 71
Sup 7, 53
30, Sup 7
76
5, Sup 7
11, Sup 7

in prep
1987
in prep
2013
1999
1991
1987
2000
1987
1987

3
2B

45
45

1989
1989

2B
3
2B

2013
2000
2013

2A

77, 101
Sup 7, 77
Sup 7, 77,
101
4, Sup 7, 71
21, Sup 7,
100A
54, 71

3
2B
2B
3
2B
3
2B
3
2B
3
2B
3

79
36, Sup 7, 71
108
92
10, Sup 7
24, Sup 7
54, 71
15, Sup 7
4, Sup 7
39, Sup 7
8, Sup 7
8, Sup 7

2001
1999
in prep
2010
1987
1987
1999
1987
1987
1987
1987
1987

1999
2012
1999

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

Volume

Year

2B

7, Sup 7

1987

3
3
2B
3
2B
2B
2A

Sup 7
Sup 7
57
57
100C
1, Sup 7
12, Sup 7, 71

1987
1987
1993
1993
2012
1987
1999

3
2B
2A

47, 71
4, Sup 7, 71
4, Sup 7, 71

1999
1999
1999

025962-77-0 trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2furyl)-vinyl]-1,3,4-oxadiazole
022975-76-4 4,4'-Dimethylangelicin plus ultraviolet A radiation
004063-41-6 4,5'-Dimethylangelicin plus ultraviolet A radiation
000087-62-7 2,6-Dimethylaniline (2,6-Xylidine)
000121-69-7 N,N-Dimethylaniline
000075-60-5 Dimethylarsinic acid
000119-93-7 3,3'-Dimethylbenzidine (ortho-Tolidine)
000079-44-7 Dimethylcarbamoyl chloride
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000068-12-2 Dimethylformamide
000057-14-7 1,1-Dimethylhydrazine
000540-73-8 1,2-Dimethylhydrazine
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000868-85-9 Dimethyl hydrogen phosphite
022349-59-3 1,4-Dimethylphenanthrene
000077-78-1 Dimethyl sulfate
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
105735-71-5 3,7-Dinitrofluoranthene
022506-53-2 3,9-Dinitrofluoranthene
075321-20-9 1,3-Dinitropyrene
042397-64-8 1,6-Dinitropyrene
042397-65-9 1,8-Dinitropyrene

3
3
2A

48, 71
Sup 7, 92
4, Sup 7, 71

1999
2010
1999

2B
2B
2B
2B
2B

2013
2013
2013
2013
2013

000101-25-7
000121-14-2
000606-20-2
000618-85-9
000123-91-1
000492-17-1
002475-45-8
002832-40-8
000097-77-8
001143-38-0
040762-15-0
000562-10-7
082413-20-5

3
2B
2B
3
2B
3
2B
3
3
3
3
3
3

46, 65, 105

46, 65, 105
46, 105
46, 105
Sup 7, 46,
105
11, Sup 7
65
65
65
11, Sup 7, 71
16, Sup 7
48
48
12, Sup 7
13; Sup 7
66
79
66

Dinitrosopentamethylenetetramine
2,4-Dinitrotoluene
2,6-Dinitrotoluene
3,5-Dinitrotoluene
1,4-Dioxane
2,4'-Diphenyldiamine
Disperse Blue 1
Disperse Yellow 3
Disulfiram
Dithranol
Doxefazepam
Doxylamine succinate
Droloxifene

13

1987
1996
1996
1996
1999
1987
1990
1990
1987
1987
1996
2001
1996

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

000150-69-6

000072-20-8

015086-94-9
000106-89-8

000106-88-7

000141-37-7
024560-98-3
066733-21-9

Agent

Group

Dry cleaning (occupational exposures in)

Dulcin
Dyes metabolized to benzidine (see Benzidine, dyes
metabolized to)
Electric fields, extremely low-frequency
Electric fields, static
Endrin
Engine exhaust, diesel
Engine exhaust, gasoline
Eosin
Epichlorohydrin
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
1,2-Epoxybutane
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
3,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6methylcyclo-hexanecarboxylate
cis-9,10-Epoxystearic acid
Epstein-Barr virus
Erionite

029975-16-4 Estazolam
Estrogen therapy, postmenopausal (see Estrogen-only
menopausal therapy)
Estrogen-only menopausal therapy
Estrogen-progestogen menopausal therapy (combined)
Estrogen-progestogen oral contraceptives (combined)
(NB: There is also convincing evidence in humans that
these agents confer a protective effect against cancer in
the endometrium and ovary)
000064-17-5 Ethanol in alcoholic beverages
000536-33-4 Ethionamide
000140-88-5 Ethyl acrylate
000100-41-4 Ethylbenzene
000051-79-6 Ethyl carbamate (Urethane)
000074-85-1 Ethylene
000106-93-4 Ethylene dibromide
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)

14

Volume

Year

2B
3

63
12, Sup 7

1995
1987

3
3
3
1
2B
3
2A

80
80
5, Sup 7
46, 105
46, 105
15, Sup 7
11, Sup 7, 71

2002
2002
1987
2013
2013
1987
1999

2B

47, 71

1999

11, Sup 7, 71

1999

3
1
1

1999
2012
2012

11, Sup 7, 71
70, 100B
42, Sup 7,
100C
66

1
1
1

72, 100A
72, 91, 100A
72, 91, 100A

2012
2012
2012

1
3
2B
2B
2A
3
2A

96, 100E
13, Sup 7
39, Sup 7, 71
77
7, Sup 7, 96
Sup 7, 60
15, Sup 7, 71

2012
1987
1999
2000
2010
1994
1999

1996

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000075-21-8 Ethylene oxide

(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
000420-12-2 Ethylene sulfide
000096-45-7 Ethylenethiourea
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
000103-11-7 2-Ethylhexyl acrylate
000062-50-0 Ethyl methanesulfonate
000759-73-9 N-Ethyl-N-nitrosourea
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
005456-28-0 Ethyl selenac
020941-65-5 Ethyl tellurac
033419-42-0 Etoposide
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
033419-42-0 Etoposide in combination with cisplatin and bleomycin
015663-27-1
011056-06-7
000097-53-0 Eugenol
000314-13-6 Evans blue
002353-45-9 Fast Green FCF
051630-58-1 Fenvalerate
014484-64-1 Ferbam
001309-37-1 Ferric oxide
Firefighter (occupational exposure as a)
Fission products, including strontium-90
Flat-glass and specialty glass (manufacture of)
002164-17-2 Fluometuron
000206-44-0 Fluoranthene
000086-73-7 Fluorene
Fluorescent lighting
016984-48-8 Fluorides (inorganic, used in drinking-water)
Fluoro-edenite fibrous amphibole
000051-21-8 5-Fluorouracil
Foreign bodies (see Surgical implants and other foreign
bodies)
000050-00-0 Formaldehyde

15

Volume

Year

Sup 7, 60,
97, 100F

2012

3
3

11, Sup 7
Sup 7, 79

1987
2001

3
2B
2A

60
7, Sup 7
17, Sup 7

1994
1987
1987

3
3
1

12, Sup 7
12, Sup 7
76, 100A

1987
1987
2012

76, 100A

2012

3
3
3
3
3
3
2B
1
3
3
3
3
3
3
1
3

36, Sup 7
8, Sup 7
16, Sup 7
53
12, Sup 7
1, Sup 7
98
100D
58
30, Sup 7
Sup 7, 92
Sup 7, 92
55
27, Sup 7
111
26, Sup 7

1987
1987
1987
1991
1987
1987
2010
2012
1993
1987
2010
2010
1992
1987
In prep
1987

Sup 7, 62,
88, 100F

2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

003570-75-0 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
Frying, emissions from high-temperature
Fuel oils, distillate (light)
Fuel oils, residual (heavy)
116355-83-0 Fumonisin B1
000110-00-9 Furan
000067-45-8 Furazolidone
000098-01-1 Furfural
Furniture and cabinet making (see Wood dust)
000054-31-9 Furosemide (Frusemide)
Fusarium graminearum, F. culmorum, and F.
crookwellense, toxins derived from (zearalenone,
deoxynivalenol, nivalenol, and fusarenone X)
116355-83-0 Fusarium moniliforme, toxins derived from (fumonisin B1,
fumonisin B2, and fusarin C)
Fusarium sporotrichioides, toxins derived from (T-2 toxin)
001303-00-0 Gallium arsenide (see Arsenic and inorganic arsenic
compounds)
Gamma-Radiation (see X- and Gamma-Radiation)
Gasoline
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
Gasoline engine exhaust (see Engine exhaust, gasoline)
025812-30-0 Gemfibrozil
090045-36-6 Ginkgo biloba extract
Glass filament, continuous
067730-11-4 Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'd]imidazole)
067730-10-3 Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)
000765-34-4 Glycidaldehyde
000556-52-5 Glycidol
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
005431-33-4 Glycidyl oleate
007460-84-6 Glycidyl stearate
1071-83-6 Glyphosate
Goldenseal root powder
000126-07-8 Griseofulvin
004680-78-8 Guinea Green B
016568-02-8 Gyromitrin

16

2B
2A
3
2B
2B
2B
3
3

Volume

Year

7, Sup 7
95
45
45
82
63
31, Sup 7
63
25, Sup 7
50
Sup 7, 56

1987
2010
1989
1989
2002
1995
1987
1995
1987
1990
1993

56

1993

56
86, 100C

1993
2012

2B

45

1989

3
2B
3
2B

66
108
43, 81
40, Sup 7

2B
2B
2A

40, Sup 7
11, Sup 7, 71
77

3
3
2A
2B
2B
3
3

11, Sup 7
11, Sup 7
112
108
Sup 7, 79
16, Sup 7
31, Sup 7

3
3

2B
3

1996
in prep
2002
1987
1987
1999
2000

1987
1987
in prep
in prep
2001
1987
1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

001317-60-8 Haematite
Haematite mining (underground)

002784-94-3
033229-34-4
002871-01-4
059820-43-8

000076-44-8
000118-74-1
000087-68-3
000067-72-1
000070-30-4
000142-83-6
000680-31-9

3
1

Hair colouring products (personal use of)

Hairdresser or barber (occupational exposure as a)
HC Blue No. 1
HC Blue No. 2
HC Red No. 3
HC Yellow No. 4
Helicobacter pylori (infection with)
Hepatitis B virus (chronic infection with)
Hepatitis C virus (chronic infection with)
Hepatitis D virus
Heptachlor
Hexachlorobenzene
Hexachlorobutadiene
Hexachlorocyclohexanes
Hexachloroethane
Hexachlorophene
2,4-Hexadienal
Hexamethylphosphoramide
High-temperature frying (see Frying)
Hot mate (see Mate, hot)
Household combustion of biomass fuel (see Biomass
fuel, indoor emissions from household combustion of)
Household combustion of coal (see Coal, indoor
emissions from household combustion)
Human herpesvirus type 4 (see Epstein-Barr virus)
Human herpesvirus type 8 (see Kaposi sarcoma
herpesvirus)
Human immunodeficiency virus type 1 (infection with)
Human immunodeficiency virus type 2 (infection with)
Human papillomavirus genus beta (except types 5 and 8)
and genus gamma
Human papillomavirus types 5 and 8 (in patients with
epidermodysplasia verruciformis)
Human papillomavirus types 6 and 11

17

Volume

Year

3
2A
2B
3
3
3
1
1
1
3
2B
2B
3
2B
2B
3
2B
2B

1, Sup 7
1, Sup 7,
100D
57, 99
57, 99
57
57
57
57
61, 100B
59, 100B
59, 100B
59
Sup 7, 53, 79
Sup 7, 79
73
20, Sup 7
73
20, Sup 7
101
15, Sup 7, 71

2010
2010
1993
1993
1993
1993
2012
2012
2012
1994
2001
2001
1999
1987
1999
1987
2013
1999

1
2B
3

67, 100B
67
90, 100B

2012
1996
2012

2B

100B

2012

90, 100B

2012

1987
2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

023255-93-8
000086-54-4
000302-01-2
007647-01-0
000058-93-5
007722-84-1
000123-31-9
000129-43-1
001689-82-3
000148-24-3
026782-43-4
000127-07-1

Human papillomavirus types 16, 18, 31, 33, 35, 39, 45,
51, 52, 56, 58, 59
(NB: The HPV types that have been classified as
carcinogenic to humans can differ by an order of
magnitude in risk for cervical cancer)
Human papillomavirus types 26, 53, 66, 67, 70, 73, 82
Human papillomavirus types 30, 34, 69, 85, 97
(NB: Classified by phylogenetic analogy to the HPV
genus alpha types classified in Group 1)
Human papillomavirus type 68
Human T-cell lymphotropic virus type I
Human T-cell lymphotropic virus type II
Hycanthone mesylate
Hydralazine
Hydrazine
Hydrochloric acid
Hydrochlorothiazide
Hydrogen peroxide
Hydroquinone
1-Hydroxyanthraquinone
4-Hydroxyazobenzene
8-Hydroxyquinoline
Hydroxysenkirkine
Hydroxyurea
Hypochlorite salts
Indeno[1,2,3-cd]pyrene
Indium phosphide
(NB: Overall evaluation upgraded to Group 2A)
Insulation glass wool
Involuntary smoking (see Tobacco smoke, second-hand)
Iodine-131 (see Radioiodines)
Ionizing radiation (all types)
IQ (2-Amino-3-methylimidazo[4,5-f]quinoline)
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Iron and steel founding (occupational exposure during)

000193-39-5
022398-80-7

010043-66-0
076180-96-6

Group

009004-66-4 Iron-dextran complex

009004-51-7 Iron-dextrin complex
001338-16-5 Iron sorbitol-citric acid complex

Year

64, 90, 100B

2012

2B
2B

100B
100B

2012
2012

2A
1
3
3
3
2B
3
2B
3
3
2B
3
3
3
3
3
2B
2A

100B
67, 100B
67
13, Sup 7
24, Sup 7
4, Sup 7, 71
54
50, 108
36, Sup 7, 71
15, Sup 7, 71
82
8, Sup 7
13, Sup 7
10, Sup 7
76
52
Sup 7, 92
86

2012
2012
1996
1987
1987
1999
1992
in prep
1999
1999
2002
1987
1987
1987
2000
1991
2010
2006

43, 81

2002

1
2A

100D
Sup 7, 56

2012
1993

34, Sup 7,
100F
2, Sup 7
2, Sup 7
2, Sup 7

2012

2B
3
3

18

Volume

1987
1987
1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

015503-86-3
000054-85-3
003778-73-2
000078-79-5
000067-63-0

Isatidine
Isonicotinic acid hydrazide (Isoniazid)
Isophosphamide
Isoprene
Isopropyl alcohol
Isopropyl alcohol manufacture using strong acids
Isopropyl oils
Isosafrole
Jacobine
JC polyomavirus (JCV)
Jet fuel
Kaempferol
Kaposi sarcoma herpesvirus
Kava extract
Kojic acid
Lasiocarpine
Lauroyl peroxide
Lead
Lead compounds, inorganic
Lead compounds, organic
(NB: Organic lead compounds are metabolized at least
in part, to ionic lead both in humans and animals. To the
extent that ionic lead, generated from organic lead, is
present in the body, it will be expected to exert the
toxicities associated with inorganic lead.)
Leather dust
Leather goods manufacture
Leather tanning and processing
Light Green SF
d-Limonene
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
Lumber and sawmill industries (including logging)
Luteoskyrin
Madder root (Rubia tinctorum)
Magenta

000120-58-1
006870-67-3

000520-18-3
009000-38-8
000501-30-4
000303-34-4
000105-74-8
007439-92-1

005141-20-8
005989-27-5

021884-44-6
000632-99-5

Group

Magenta production

3
3
3
2B
3
1
3
3
3
2B
3
3
1
2B
3
2B
3
2B
2A
3

19

Year

10, Sup 7
4, Sup 7
26, Sup 7
60, 71
15, Sup 7, 71
Sup 7, 100F
15, Sup 7, 71
10, Sup 7
10, Sup 7
104
45
31, Sup 7
70, 100B
108
79
10, Sup 7
36, Sup 7, 71
23, Sup 7
Sup 7, 87
23, Sup 7, 87

1987
1987
1987
1999
1999
2012
1999
1987
1987
2013
1989
1987
2012
in prep
2001
1987
1999
1987
2006
2006

1
3
3
3
3

100C
25, Sup 7
25, Sup 7
16, Sup 7
56, 73

2012
1987
1987
1987
1999

3
3
3
2B

25, Sup 7
10, Sup 7
82
Sup 7, 57,
99, 100F
Sup 7, 57,
99, 100F
80

1987
1987
2002
2012

Magnetic fields, extremely low-frequency

Volume

2B

2012
2002

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

Volume

Magnetic fields, static

Malaria (caused by infection with Plasmodium falciparum
in holoendemic areas)
000121-75-5 Malathion

3
2A

80
104

2A

000123-33-1
000542-78-9
012427-38-2
000551-74-6

3
3
3
3
3
2A
2B
3
2B
2B
2B
3

30, Sup 7,
112
4, Sup 7
36, Sup 7, 71
12, Sup 7
9, Sup 7
51
51
40, Sup 7
9, Sup 7
21, Sup 7
Sup 7, 56
Sup 7, 56
Sup 7, 73

068006-83-7
013045-94-8
000071-58-9
077094-11-2
077500-04-0
000108-78-1

000148-82-3

Maleic hydrazide
Malonaldehyde
Maneb
Mannomustine dihydrochloride
Mate
Mate, hot
MeA-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole)
Medphalan
Medroxyprogesterone acetate
MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline)
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline)
Melamine
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
Melphalan

000050-44-2 6-Mercaptopurine
007439-97-6 Mercury and inorganic mercury compounds
Merkel cell polyomavirus (MCV)
000531-76-0 Merphalan
Metabisulfites
000060-56-0 Methimazole
000059-05-2 Methotrexate
000072-43-5 Methoxychlor
000298-81-7 Methoxsalen (8-methoxypsoralen) plus ultraviolet A
radiation
000484-20-8 5-Methoxypsoralen
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000096-33-3 Methyl acrylate
073459-03-7 5-Methylangelicin plus ultraviolet A radiation
000124-58-3 Methylarsonic acid
000075-55-8 2-Methylaziridine (Propyleneimine)
000592-62-1 Methylazoxymethanol acetate
000074-83-9 Methyl bromide

20

Year
2002
2013
in prep
1987
1999
1987
1987
1991
1991
1987
1987
1987
1993
1993
1999

1987
1993
2013
1987
1992
2001
1987
1987
2012

2A

9, Sup 7,
100A
26, Sup 7
58
104
9, Sup 7
54
79
26, Sup 7
20, Sup 7
24, Sup 7,
100A
40, Sup 7

3
3
2B
2B
2B
3

39, Sup 7, 71
Sup 7
100C
9, Sup 7, 71
10, Sup 7
41, Sup 7, 71

1999
1987
2012
1999
1987
1999

3
3
2A
2B
3
3
3
3
1

2012

1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

001634-04-4
000598-55-0
013909-09-6
000074-87-3
003351-28-8
003351-32-4
003351-31-3
003351-30-2
003697-24-3
001705-85-7
000099-80-9
000101-14-4

Methyl tert-butyl ether

Methyl carbamate
Methyl-CCNU
Methyl chloride
1-Methylchrysene
2-Methylchrysene
3-Methylchrysene
4-Methylchrysene
5-Methylchrysene
6-Methylchrysene
N-Methyl-N,4-dinitrosoaniline
4,4'-Methylenebis(2-chloroaniline) (MOCA)
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
4,4'-Methylene bis(2-methylaniline)
Methylene blue
4,4'-Methylenedianiline
4,4'-Methylenediphenyl diisocyanate
Methyleugenol
2-Methylfluoranthene
3-Methylfluoranthene
Methylglyoxal
2-Methylimidazole
4-Methylimidazole
Methyl iodide
Methyl isobutyl ketone
Methylmercury compounds
(NB: Evaluated as a group)
Methyl methacrylate
Methyl methanesulfonate
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
2-Methyl-1-nitroanthraquinone (uncertain purity)
N-Methyl-N-nitro-N-nitrosoguanidine (MNNG)
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
N-Methyl-N-nitrosourea
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
N-Methyl-N-nitrosourethane

000838-88-0
007220-79-3
000101-77-9
000101-68-8
000093-15-2
033543-31-6
001706-01-0
000078-98-8
000693-98-1
000822-36-6
000074-88-4
000108-10-1

000080-62-6
000066-27-3

000129-15-7
000070-25-7

000684-93-5

000615-53-2

Group

21

Volume

Year

3
3
1
3
3
3
3
3
2B
3
3
1

73
12, Sup 7
Sup 7, 100A
41, Sup 7, 71
Sup 7, 92
Sup 7, 92
Sup 7, 92
Sup 7, 92
Sup 7, 92
Sup 7, 92
1, Sup 7
Sup 7, 57,
99, 100F

1999
1987
2012
1999
2010
2010
2010
2010
2010
2010
1987
2012

2B
3
2B
3
2B
3
3
3
2B
2B
3
2B
2B

4, Sup 7
108
39, Sup 7
19, Sup 7, 71
101
Sup 7, 92
Sup 7, 92
51
101
101
41, Sup 7, 71
101
58

1987
in prep
1987
1999
2013
2010
2010
1991
2013
2013
1999
2013
1993

3
2A

Sup 7, 60
7, Sup 7, 71

1994
1999

2B
2A

27, Sup 7
4, Sup 7

1987
1987

2A

17, Sup 7

1987

2B

4, Sup 7

1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

090456-67-0
000298-00-0
000832-69-9
085878-63-3
000493-52-7
000144-34-3
000098-83-9

N-Methylolacrylamide
Methyl parathion
1-Methylphenanthrene
7-Methylpyrido[3,4-c]psoralen
Methyl red
Methyl selenac

000056-04-2
000443-48-1
000101-61-1
000090-94-8
101043-37-2

Group

-Methylstyrene
Methylthiouracil
Metronidazole
Michlers base [4,4-methylenebis(N,N-dimethyl)benzenamine]
Michlers ketone [4,4-Bis(dimethylamino)benzophenone]
Microcystin-LR
Microcystis extracts
Mineral oils, highly-refined
Mineral oils, untreated or mildly treated

002385-85-5 Mirex
000050-07-7 Mitomycin C
065271-80-9 Mitoxantrone
Modacrylic fibres
000096-24-2 3-Monochloro-1,2-propanediol
000315-22-0 Monocrotaline
000124-58-3 Monomethylarsonic acid (see Methylarsonic acid)
000150-68-5 Monuron
MOPP and other combined chemotherapy including
alkylating agents
000110-91-8 Morpholine
003795-88-8 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2oxazolidinone
308068-56-6 Multi-walled carbon nanotubes MWCNT-7 (see Carbon
nanotubes, multi-walled MWCNT-7)
308068-56-6 Multi-walled carbon nanotubes other than MWCNT-7
(see Carbon nanotubes, multi-walled, other than
MWCNT-7)
000083-66-9 Musk ambrette
000081-15-2 Musk xylene
000505-60-2 Mustard gas (see Sulfur mustard)
000055-98-1 Myleran (see Busulfan)
003771-19-5 Nafenopin

22

Volume

Year

3
3
3
3
3
3
2B

60
30, Sup 7
Sup 7, 92
40, Sup 7
8, Sup 7
12, Sup 7
101

1994
1987
2010
1987
1987
1987
2013

2B
2B
2B

Sup 7, 79
13, Sup 7
27, Sup 7, 99

2001
1987
2010

2B
2B
3
3
1

2010
2010
2010
1987
2012

2B
2B
2B
3
2B
2B
2B
3
1

99
94
94
33, Sup 7
33, Sup 7,
100F
20, Sup 7
10, Sup 7
76
19, Sup 7
101
10, Sup 7
100C
Sup 7, 53
Sup 7, 100A

1987
1987
2000
1987
2013
1987
2012
1991
2012

3
2B

47, 71
7, Sup 7

1999
1987

65
65

1996
1996

24, Sup 7

1987

3
3

2B

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

000091-20-3
002243-62-1
003173-72-6
111189-32-3
000203-20-3
000193-09-9
000134-32-7
000091-59-8

Naphthalene
1,5-Naphthalenediamine
1,5-Naphthalene diisocyanate
Naphtho[1,2-b]fluoranthene
Naphtho[2,1-a]fluoranthene
Naphtho[2,3-e]pyrene
1-Naphthylamine
2-Naphthylamine

Group
2B
3
3
3
3
3
3
1

000086-88-4 1-Naphthylthiourea (ANTU)

000139-94-6 Nithiazide
Neutron radiation
(NB: Overall evaluation upgraded to Group 1 with
supporting evidence from other relevant data)
007440-02-0 Nickel, metallic and alloys
Nickel compounds

Volume

Year

82
27, Sup 7
19, Sup 7, 71
92
92
92
4, Sup 7
4, Sup 7, 99,
100F
30, Sup 7
31, Sup 7
75, 100D

2002
1987
1999
2010
2010
2010
1987
2012

1990
2012

2B
2A

Sup 7, 49
Sup 7, 49,
100C
11
13, Sup 7
94

1976
1987
2010

3
3
1

2B
1

1987
1987
2012

2B

48, 73

1999

000602-87-9
000099-59-2
000091-23-6
000602-60-8
017117-34-9
000098-95-3
020268-51-3
063041-90-7
000092-93-3
007496-02-8

Nickel refining (see Nickel compounds)

Niridazole
Nitrate or nitrite (ingested) under conditions that result in
endogenous nitrosation
Nitrilotriacetic acid and its salts
(NB: Evaluated as a group)
5-Nitroacenaphthene
5-Nitro-ortho-anisidine
2-Nitroanisole
9-Nitroanthracene
3-Nitrobenzanthrone
Nitrobenzene
7-Nitrobenz[a]anthracene
6-Nitrobenzo[a]pyrene
4-Nitrobiphenyl
6-Nitrochrysene

2B
3
2B
3
2B
2B
3
3
3
2A

1987
1987
1996
1987
2013
1996
1989
1989
1987
2013

001836-75-5
000892-21-7
000607-57-8
000059-87-0
000067-20-9
000555-84-0

Nitrofen (technical-grade)
3-Nitrofluoranthene
2-Nitrofluorene
Nitrofural (Nitrofurazone)
Nitrofurantoin
1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone

2B
3
2B
3
3
2B

16, Sup 7
27, Sup 7
65
33, Sup 7
105
65
46
Sup 7, 46
4, Sup 7
Sup 7, 46,
105
30, Sup 7
33, Sup 7
46, 105
50
50
7, Sup 7

000061-57-4

000139-13-9

23

1987
1987
2013
1990
1990
1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

000531-82-8
000051-75-2
000126-85-2
000075-52-5
000086-57-7
000581-89-5
020589-63-3
000079-46-9
005522-43-0

N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide
Nitrogen mustard
Nitrogen mustard N-oxide
Nitromethane
1-Nitronaphthalene
2-Nitronaphthalene
3-Nitroperylene
2-Nitropropane
1-Nitropyrene

2B
2A
2B
2B
3
3
3
2B
2A

000789-07-1
057835-92-4
037620-20-5
071267-22-6
000924-16-3
001116-54-7
000055-18-5

2-Nitropyrene
4-Nitropyrene
N'-Nitrosoanabasine (NAB)
N'-Nitrosoanatabine (NAT)
N-Nitrosodi-n-butylamine
N-Nitrosodiethanolamine
N-Nitrosodiethylamine
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
N-Nitrosodimethylamine
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
N-Nitrosodiphenylamine
para-Nitrosodiphenylamine
N-Nitrosodi-n-propylamine
N-Nitrosofolic acid
N-Nitrosoguvacine
N-Nitrosoguvacoline
N-Nitrosohydroxyproline
3-(N-Nitrosomethylamino)propionaldehyde
3-(N-Nitrosomethylamino)propionitrile
N-Nitrosomethylethylamine
N-Nitrosomethylvinylamine
N-Nitrosomorpholine
N'-Nitrosonornicotine (NNN) and 4-(NNitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
N-Nitrosopiperidine
N-Nitrosoproline

000062-75-9

000086-30-6
000156-10-5
000621-64-7
029291-35-8
055557-01-2
055557-02-3
030310-80-6
085502-23-4
060153-49-3
010595-95-6
004549-40-0
000059-89-2
016543-55-8
064091-91-4

000100-75-4
007519-36-0

Group

24

Volume

Year
1987
1987
1987
2000
1989
1989
1989
1999
2013

3
2B
3
3
2B
2B
2A

7, Sup 7
9, Sup 7
9, Sup 7
77
46
46
46
29, Sup 7, 71
Sup 7, 46,
105
46
46, 105
37, Sup 7, 89
37, Sup 7, 89
17, Sup 7
17, Sup 7, 77
17, Sup 7

2A

17, Sup 7

1987

3
3
2B
3
3
3
3
3
2B
2B
2B
2B
1

27, Sup 7
27, Sup 7
17, Sup 7
17, Sup 7
Sup 7, 85
Sup 7, 85
17, Sup 7
Sup 7, 85
Sup 7, 85
17, Sup 7
17, Sup 7
17, Sup 7
Sup 7, 89,
100E

1987
1987
1987
1987
2004
2004
1987
2004
2004
1987
1987
1987
2012

2B
3

17, Sup 7
17, Sup 7

1987
1987

1989
2013
2007
2007
1987
2000
1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000930-55-2 N-Nitrosopyrrolidine
013256-22-9 N-Nitrososarcosine
000088-72-2 2-Nitrotoluene
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000099-08-1 Nitrotoluenes
000099-99-0
000099-55-8 5-Nitro-ortho-toluidine
000804-36-4 Nitrovin
118399-22-7 Nodularins
Non-arsenical insecticides (occupational exposures in
spraying and application of)
025038-54-4 Nylon 6
000303-47-9 Ochratoxin A
022966-79-6 Oestradiol mustard
Oestrogen (see Estrogen)
002646-17-5 Oil Orange SS
Opisthorchis felineus (infection with)
Opisthorchis viverrini (infection with)
Oral contraceptives, combined estrogen-progestogen
(see Estrogen-progestogen oral contraceptives)
000523-44-4 Orange I (see CI Acid Orange 20)
001936-15-8 Orange G (see CI Orange G)
Outdoor air pollution
Outdoor air pollution, particulate matter in
000604-75-1 Oxazepam
000129-20-4 Oxyphenbutazone
Painter (occupational exposure as a)
Paint manufacture (occupational exposure in)
012174-11-7 Palygorskite (Attapulgite) (long fibres, > 5 micrometres)
012174-11-7 Palygorskite (Attapulgite)(short fibres, < 5 micrometres)
000794-93-4 Panfuran S (containing dihydroxymethylfuratrizine)
000103-90-2 Paracetamol (Acetaminophen)
010048-32-5 Parasorbic acid
000056-38-2 Parathion
Particulate matter in outdoor air pollution (see Outdoor air
pollution, particulate matter in)
000149-29-1 Patulin

25

2B
2B
2A

Volume

Year

17, Sup 7
17, Sup 7
101

1987
1987
2013

65

1996

3
3
3
2A

48
31, Sup 7
94
53

1990
1987
2010
1991

3
2B
3

19, Sup 7
Sup 7, 56
9, Sup 7

1987
1993
1987

2B
3
1

8, Sup 7
61
61, 100B

1987
1994
2012

1
1
2B
3
1
3
2B
3
2B
3
3
2B

109
109
Sup 7, 66
13, Sup 7
47, 98, 100F
47
68
68
24, Sup 7
50, 73
10, Sup 7
30, Sup 7,
112

40, Sup 7

in prep
in prep
1996
1987
2012
1989
1997
1997
1987
1999
1987
in prep

1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

Paving and roofing with coal-tar pitch (see Coal-tar pitch)

000090-65-3 Penicillic acid
057465-28-8 3,4,5,3,4-Pentachlorobiphenyl (PCB-126)
(see Polychlorinated biphenyls, dioxin-like, with a TEF
according to WHO)
057117-31-4 2,3,4,7,8-Pentachlorodibenzofuran
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
000076-01-7 Pentachloroethane
000087-86-5 Pentachlorophenol (see Polychlorophenols)
037319-17-8 Pentosan polysulfate sodium
000335-67-1 Perfluorooctanoic acid
052645-53-1 Permethrin
000198-55-0 Perylene
060102-37-6 Petasitenine
Petroleum refining (occupational exposures in)
Petroleum solvents
Pickled vegetables (traditional Asian)
000062-44-2 Phenacetin
(NB: Overall evaluation upgraded to Group 1 with
supporting evidence from other relevant data)
Phenacetin, analgesic mixtures containing
000085-01-8 Phenanthrene
000136-40-3 Phenazopyridine hydrochloride
000156-51-4 Phenelzine sulfate
000103-03-7 Phenicarbazide
000050-06-6 Phenobarbital
000108-95-2 Phenol
000077-09-8 Phenolphthalein
000063-92-3 Phenoxybenzamine hydrochloride
000050-33-9 Phenylbutazone
000108-45-2 meta-Phenylenediamine
000106-50-3 para-Phenylenediamine
000122-60-1 Phenyl glycidyl ether
000135-88-6 N-Phenyl-2-naphthylamine
000090-43-7 ortho-Phenylphenol
000057-41-0 Phenytoin
105650-23-5 PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)
014596-37-3 Phosphorus-32, as phosphate

26

Volume

Year

3
1

35, Sup 7,
92, 100F
10, Sup 7
100F

1987
2012

100F

2012

41, Sup 7, 71
53, 71
108
110
53
Sup 7, 92
31, Sup 7
45
47
56
24, Sup 7,
100A

1999
1999
in prep
in prep
1991
2010
1987
1989
1989
1993
2012

Sup 7, 100A
Sup 7, 92
24, Sup 7
24, Sup 7
12, Sup 7
Sup 7, 79
47, 71
76
24, Sup 7
13, Sup 7
16, Sup 7
16, Sup 7
47, 71
16, Sup 7
73
Sup 7, 66
56
78, 100D

2012
2010
1987
1987
1987
2001
1999
2000
1987
1987
1987
1987
1999
1987
1999
1996
1993
2012

2B
2B
3
3
3
2A
3
2B
1

1
3
2B
3
3
2B
3
2B
2B
3
3
3
2B
3
3
2B
2B
1

2010

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000213-46-7
001918-02-1
111025-46-8
000051-03-6
007440-07-5
053973-98-1
009003-01-4
059536-65-1

Picene
Picloram
Pioglitazone
Piperonyl butoxide
Plutonium
Poligeenan (see Carrageenan, degraded)
Polyacrylic acid
Polybrominated biphenyls
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data, namely
mechanistic similarity with polychlorinated biphenyls
classified in Group 1)
001336-36-3 Polychlorinated biphenyls

009010-98-4
009002-88-4
009016-87-9
009011-14-7
009003-07-0
009003-53-6
009002-84-0
009009-54-5
009003-20-7
009002-89-5
009002-86-2
009003-39-8
003564-09-8
003761-53-3
004548-53-2
023746-34-1

Polychlorinated biphenyls, dioxin-like, with a Toxicity

Equivalency Factor (TEF) according to WHO (PCBs 77,
81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189)
(NB: Overall evaluation upgraded to Group 1 with
strong supporting evidence from other relevant data)
Polychlorinated dibenzo-para-dioxins (other than 2,3,7,8tetrachlorodibenzo-para-dioxin)
Polychlorinated dibenzofurans
(see 2,3,4,7,8-Pentachlorodibenzofuran)
Polychlorophenols and their sodium salts (mixed
exposures)
Polychloroprene
Polyethylene
Polymethylene polyphenyl isocyanate
Polymethyl methacrylate
Polypropylene
Polystyrene
Polytetrafluoroethylene
Polyurethane foams
Polyvinyl acetate
Polyvinyl alcohol
Polyvinyl chloride
Polyvinyl pyrrolidone
Ponceau 3R
Ponceau MX
Ponceau SX
Potassium bis(2-hydroxyethyl)dithiocarbamate

27

Volume

Year

3
3
2A
3
1

92
53
108
30, Sup 7
78, 100D

2010
1991
in prep
1987
2012

3
2A

19, Sup 7
41, Sup 7,
107

1987
in prep

in prep

18, Sup 7,
107
107

69

1997

69

1997

2B

53, 71

1999

3
3
3
3
3
3
3
3
3
3
3
3
2B
2B
3
3

19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7, 71
8, Sup 7
8, Sup 7
8, Sup 7
12, Sup 7

1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987

in prep

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

007758-01-2
002955-38-6
029069-24-7
000053-03-2
000125-33-7

Potassium bromate
Prazepam
Prednimustine
Prednisone
Primidone
Printing inks
Printing processes (occupational exposures in)
Procarbazine hydrochloride
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Proflavine salts
Progestins
Progestogen-only contraceptives
Pronetalol hydrochloride
1,3-Propane sultone
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Propham
beta-Propiolactone
n-Propyl carbamate
Propylene
Propylene oxide
Propylthiouracil
Ptaquiloside
Pulegone
Pulp and paper manufacture
Pyrene
Pyridine
Pyrido[3,4-c]psoralen
Pyrimethamine
Quercetin
para-Quinone
Quintozene (Pentachloronitrobenzene)
Radiofrequency electromagnetic fields1
Radioiodines, including iodine-131
Radionuclides, alpha-particle-emitting, internally
deposited
(NB: Specific radionuclides for which there is sufficient
evidence in humans are also listed individually as
Group 1 agents)

000366-70-1

000051-02-5
001120-71-4

000122-42-9
000057-57-8
000627-12-3
000115-07-1
000075-56-9
000051-52-5
087625-62-5
000089-82-7
000129-00-0
000110-86-1
085878-62-2
000058-14-0
000117-39-5
000106-51-4
000082-68-8

Group

28

Volume

Year

2B
3
3
3
2B
3
2B
2A

Sup 7, 73
66
50
26, Sup 7
108
65
65
26, Sup 7

1999
1996
1990
1987
in prep
1996
1996
1987

3
2B
2B
3
2A

24, Sup 7
Sup 7
72
13, Sup 7
4, Sup 7, 71,
110

1987
1987
1999
1987
in prep

3
2B
3
3
2B
2B
3
2B
3
3
3
3
3
3
3
3
2B
1
1

12, Sup 7
4, Sup 7, 71
12, Sup 7
Sup 7, 60
Sup 7, 60
Sup 7, 79
40, Sup 7
108
25, Sup 7
Sup 7, 92
77
40, Sup 7
13, Sup 7
Sup 7, 73
15, Sup 7, 71
5, Sup 7
102
78, 100D
78, 100D

1987
1999
1987
1994
1994
2001
1987
in prep
1987
2010
2000
1987
1987
1999
1999
1987
2013
2012
2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

013233-32-4
013982-63-3
015262-20-1
010043-92-2
000050-55-5
000108-46-3
000480-54-6
000081-88-9
000989-38-8
023246-96-0
013292-46-1
026308-28-1
122320-73-4

Agent

Group

Radionuclides, beta-particle-emitting, internally deposited

(NB: Specific radionuclides for which there is sufficient
evidence in humans are also listed individually as
Group 1 agents)
Radium-224 and its decay products
Radium-226 and its decay products
Radium-228 and its decay products
Radon-222 and its decay products
Refractory ceramic fibres
Reserpine
Resorcinol
Retrorsine
Rhodamine B
Rhodamine 6G
Riddelliine
Rifampicin
Ripazepam
Rosiglitazone
Rubber manufacturing industry

023537-16-8 Rugulosin
Rock (stone) wool
008047-67-4 Saccharated iron oxide
000081-07-2 Saccharin and its salts
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
000094-59-7 Safrole
Salted fish, Chinese-style
000085-83-6 Scarlet Red
Schistosoma haematobium (infection with)
Schistosoma japonicum (infection with)
Schistosoma mansoni (infection with)
007782-49-2 Selenium and selenium compounds
000563-41-7 Semicarbazide hydrochloride
013909-09-6 Semustine (see Methyl-CCNU)
000480-81-9 Seneciphylline
002318-18-5 Senkirkine
015501-74-3 Sepiolite
068308-34-9 Shale oils

29

1
1
1
1
2B
3
3
3
3
3
2B
3
3
3
1
3
3
3
3

Volume
78, 100D

78, 100D
78, 100D
78, 100D
43, 78, 100D
43, 81
24, Sup 7
15, Sup 7, 71
10, Sup 7
16, Sup 7
16, Sup 7
10, Sup 7, 82
24, Sup 7
66
108
28, Sup 7,
100F
40, Sup 7
43, 81
2, Sup 7
Sup 7, 73

Year
2012

2012
2012
2012
2012
2002
1987
1999
1987
1987
1987
2002
1987
1996
in prep
2012
1987
2002
1987
1999

2B
1
3
1
2B
3
3
3

10, Sup 7
56, 100E
8, Sup 7
61, 100B
61
61
9, Sup 7
12, Sup 7

1987
2012
1987
2012
1994
1994
1987
1987

3
3
3
1

10, Sup 7
31, Sup 7
Sup 7, 68
35, Sup 7,
100F

1987
1987
1997
2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

Shiftwork that involves circadian disruption

000138-59-0 Shikimic acid
007631-86-9 Silica, amorphous
014808-60-7 Silica dust, crystalline, in the form of quartz or cristobalite

2A
3
3
1

308076-74-6
409-21-2
000122-34-9
308068-56-6

2B
2A
3

007758-19-2
000148-18-5
000132-27-4

000052-01-7
010048-13-2
018883-66-4
007664-93-9
010098-97-2
000100-42-5
009003-54-7
009003-55-8
000096-09-3

000108-30-5
000842-07-9
003118-97-6
000085-86-9
006416-57-5
006368-72-5
000127-69-5
000095-06-7

Silicon carbide, fibrous

Silicon carbide whiskers
Simazine
Single-walled carbon nanotubes (see Carbon nanotubes,
single-walled)
Slag wool
Sodium chlorite
Sodium diethyldithiocarbamate
Sodium ortho-phenylphenate
Solar radiation
Soot (as found in occupational exposure of chimney
sweeps)
Special-purpose fibres such as E-glass and '475' glass
fibres
Spironolactone
Sterigmatocystin
Streptozotocin
Strong-inorganic-acid mists containing sulfuric acid (see
Acid mists)
Strontium-90 (see Fission products)
Styrene
Styrene-acrylonitrile copolymers
Styrene-butadiene copolymers
Styrene-7,8-oxide
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Succinic anhydride
Sudan I
Sudan II
Sudan III
Sudan Brown RR
Sudan Red 7B
Sulfafurazole (Sulfisoxazole)
Sulfallate

30

3
3
3
2B
1
1

Volume
98
40, Sup 7
Sup 7, 68
Sup 7, 68,
100C
111
111
53, 73

Year
2010
1987
1997
2012
In prep
In prep
1999

2002
1991
1987
1999
2012
2012

2B

43, 81
52
12, Sup 7
Sup 7, 73
55, 100D
35, Sup 7,
92, 100F
81

3
2B
2B

Sup 7, 79
10, Sup 7
17, Sup 7

2001
1987
1987

2B
3
3
2A

60, 82
19, Sup .7
19, Sup 7
Sup 7, 60

2002
1987
1987
1994

3
3
3
3
3
3
3
2B

15, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
24, Sup 7
30, Sup 7

1987
1987
1987
1987
1987
1987
1987
1987

2002

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

000057-68-1 Sulfamethazine
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
000723-46-6 Sulfamethoxazole
000599-79-1 Sulfasalazine
Sulfites
007446-09-5 Sulfur dioxide
000505-60-2 Sulfur mustard

002783-94-0

022571-95-5
014807-96-6
014807-96-6
014807-96-6
010540-29-1

001401-55-4
000846-50-4

Sunlamps and sunbeds (see Ultraviolet-emitting tanning

devices)
Sunset Yellow FCF
Surgical implants and other foreign bodies:
- Polymeric implants prepared as thin smooth film (with
the exception of poly(glycolic acid))
- Metallic implants prepared as thin smooth films
- Implanted foreign bodies of metallic cobalt, metallic
nickel and an alloy powder containing 66-67% nickel,
13-16% chromium and 7% iron
Surgical implants and other foreign bodies:
- Organic polymeric materials (as a group)
- Orthopaedic implants of complex composition
- Cardiac pacemakers
- Silicone breast implants
- Implanted foreign bodies of metallic chromium or
titanium and of cobalt-based, chromium-based and
titanium-based alloys, stainless steel and depleted
uranium
- Dental materials
- Ceramic implants
SV40 polyomavirus
Symphytine
Talc containing asbestiform fibres (see Asbestos)
Talc not containing asbestos or asbestiform fibres
Talc-based body powder (perineal use of)
Tamoxifen
(NB: There is also conclusive evidence that tamoxifen
reduces the risk of contralateral breast cancer in breast
cancer patients)
Tannic acid and tannins
Tea
Temazepam

31

Volume
79

Year
2001

3
2B
3
3
1

Sup 7, 79
108
54
54
9, Sup 7,
100F

2001
in prep
1992
1992
2012

3
2B

8, Sup 7
74

1987
1999

74

1999

3
3

104
31, Sup 7
42, Sup 7
42, Sup 7, 93
93
66, 100A

2013
1987
1987
2010
2010
2012

10, Sup 7
51
66

1987
1991
1996

3
2B
1

3
3
3

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

029767-20-2 Teniposide
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
008001-50-1 Terpene polychlorinates (Strobane)
015721-02-5 2,2',5,5'-Tetrachlorobenzidine
001746-01-6 2,3,7,8-Tetrachlorodibenzo-para-dioxin

2A

000630-20-6 1,1,1,2-Tetrachloroethane

2B

000079-34-5 1,1,2,2-Tetrachloroethane

2B

000127-18-4 Tetrachloroethylene (Perchloroethylene)

2A

022248-79-9 Tetrachlorvinphos

2B

000116-14-3 Tetrafluoroethylene
(NB: Overall evaluation upgraded to Group 2A)
Tetrakis(hydroxymethyl)phosphonium salts
000509-14-8 Tetranitromethane
Textile manufacturing industry (work in)
000083-67-0 Theobromine
000058-55-9 Theophylline
000062-55-5 Thioacetamide
000139-65-1 4,4'-Thiodianiline
000052-24-4 Thiotepa

2A

000141-90-2
000062-56-6
000137-26-8
007440-29-1
013463-67-7

2B
3
3
1
2B
1

Thiouracil
Thiourea
Thiram
Thorium-232 and its decay products
Titanium dioxide
Tobacco, smokeless

3
3
1

3
2B
2B
3
3
2B
2B
1

Tobacco smoke, second-hand

Tobacco smoking
000108-88-3 Toluene
026471-62-5 Toluene diisocyanates
000095-53-4 ortho-Toluidine

1
1
3
2B
1

089778-26-7 Toremifene
008001-35-2 Toxaphene (Polychlorinated camphenes)

3
2B

32

Volume

Year

76

2000

5, Sup 7
27, Sup 7
Sup 7, 69,
100F
41, Sup 7,
71, 106
20, Sup 7,
71, 106
Sup 7, 63,
106
30, Sup 7,
112
19, Sup 7,
71, 110
48, 71
65
48
51
51
7, Sup 7
27, Sup 7
Sup 7, 50,
100A
Sup 7, 79
Sup 7, 79
Sup 7, 53
78, 100D
47, 93
Sup 7, 89,
100E
83, 100E
83, 100E
47, 71
39, Sup 7, 71
Sup 7, 77,
99, 100F
66
Sup 7, 79

1987
1987
2012
2014
2014
2014
in prep
in prep
1999
1996
1990
1991
1991
1987
1987
2012
2001
2001
1991
2012
2010
2012
2012
2012
1999
1999
2012
1996
2001

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

Toxins derived from certain Fusarium species (see

Fusarium)
000299-75-2 Treosulfan
000396-01-0
021259-20-1
000052-68-6
000817-09-4
000076-03-9
000545-06-2
000071-55-6
000079-00-5
000079-01-6

Triamterene
T2-Trichothecene
Trichlorfon
Trichlormethine (Trimustine hydrochloride)
Trichloroacetic acid
Trichloroacetonitrile
1,1,1-Trichloroethane
1,1,2-Trichloroethane
Trichloroethylene

2B
3
3
2B
2B
3
3
3
1

000096-18-4
000102-71-6
001954-28-5
001582-09-8
090370-29-9
000137-17-7
000088-05-1
003902-71-4
000118-96-7
000217-59-4
000068-76-8
000545-55-1
000051-18-3
000115-96-8
038571-73-2
000126-72-7

1,2,3-Trichloropropane
Triethanolamine
Triethylene glycol diglycidyl ether
Trifluralin
4,4',6-Trimethylangelicin plus ultraviolet A radiation
2,4,5-Trimethylaniline
2,4,6-Trimethylaniline
4,5',8-Trimethylpsoralen
2,4,6-Trinitrotoluene
Triphenylene
Tris(aziridinyl)-para-benzoquinone (Triaziquone)
Tris(1-aziridinyl)phosphine oxide
2,4,6-Tris(1-aziridinyl)-s-triazine
Tris(2-chloroethyl) phosphate
1,2,3-Tris(chloromethoxy)propane
Tris(2,3-dibromopropyl) phosphate
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Tris(2-methyl-1-aziridinyl)phosphine oxide
Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole)
Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole)
Trypan blue
Tungsten carbide with cobalt metal (see Cobalt metal
with tungsten carbide)

2A
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2A

26, Sup 7,
100A
108
31, Sup 7
30, Sup 7
Sup 7, 50
63, 84, 106
52, 71
20, Sup 7, 71
52, 71
Sup 7, 63,
106
63
77
11, Sup 7, 71
53
Sup 7
27, Sup 7
27, Sup 7
40, Sup 7
65
Sup 7, 92
9, Sup 7
9, Sup 7
9, Sup 7
48, 71
15, Sup 7, 71
20, Sup 7, 71

3
2B
2B
2B

9, Sup 7
31, Sup 7
31, Sup 7
8, Sup 7

000057-39-6
062450-06-0
062450-07-1
000072-57-1
012070-12-1
007440-48-4

33

Volume

Year

2012
in prep
1987
1987
1990
2014
1999
1999
1999
2014
1995
2000
1999
1991
1987
1987
1987
1987
1996
2010
1987
1987
1987
1999
1999
1999

1987
1987
1987
1987

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

000066-75-1
001314-62-1
000128-66-5
000143-67-9
002068-78-2
000108-05-4
000593-60-2

000075-01-4
009003-22-9
000100-40-3
000106-87-6
000075-02-5

000075-35-4
009011-06-7
000075-38-7
000088-12-0
025013-15-4
012001-79-5

013983-17-0

Agent

Group

Ultraviolet radiation (wavelengths 100-400 nm,

encompassing UVA, UVB, and UVC)
Ultraviolet-emitting tanning devices
Uracil mustard
Urethane (see Ethyl carbamate)
Vanadium pentoxide
Vat Yellow 4
Vinblastine sulfate
Vincristine sulfate
Vinyl acetate
Vinyl bromide
(NB: (1) Overall evaluation upgraded to Group 2A
based on mechanistic and other relevant data;
(2) For practical purposes, vinyl bromide should be
considered to act similarly to the human carcinogen
vinyl chloride.)
Vinyl chloride
Vinyl chloride-vinyl acetate copolymers
4-Vinylcyclohexene
4-Vinylcyclohexene diepoxide
Vinyl fluoride
(NB: (1) Overall evaluation upgraded to Group 2A
based on mechanistic and other relevant data;
(2) For practical purposes, vinyl fluoride should be
considered to act similarly to the human carcinogen
vinyl chloride.)
Vinylidene chloride
Vinylidene chloride-vinyl chloride copolymers
Vinylidene fluoride
N-Vinyl-2-pyrrolidone
Vinyl toluene
Vitamin K substances
Welding fumes
(NB: Volume 100D concluded that there is sufficient
evidence for ocular melanoma in welders)
Wollastonite
Wood dust
Wood smoke (see Biomass fuel, indoor emissions from
household combustion)
X- and Gamma-Radiation

34

Volume

Year

55, 100D

2012

1
2B

100D
9, Sup 7

2012
1987

2B
3
3
3
2B
2A

86
48
26, Sup 7
26, Sup 7
Sup 7, 63
39, Sup 7,
71, 97

2006
1990
1987
1987
1995
2008

2012

3
2B
2B
2A

Sup 7, 97,
100F
19, Sup 7
Sup 7, 60
Sup 7, 60
Sup 7, 63, 97

1987
1994
1994
2008

3
3
3
3
3
3
2B

39, Sup 7, 71
19, Sup 7
39, Sup 7, 71
19, Sup 7, 71
60
76
49

1999
1987
1999
1999
1994
2000
1990

3
1

Sup 7, 68
62, 100C

1997
2012

75, 100D

2012

Agents Classified by the IARC Monographs, Volumes 1112

CAS No

Agent

Group

001330-20-7
000095-68-1
000095-78-3
000085-84-7
000131-79-3
007481-89-2
000315-18-4
001318-02-1

Xylenes
2,4-Xylidine
2,5-Xylidine
Yellow AB
Yellow OB
Zalcitabine
Zectran
Zeolites other than erionite (clinoptilolite,
phillipsite,mordenite, non-fibrous Japanese zeolite,
synthetic zeolites)
030516-87-1 Zidovudine (AZT)
012122-67-7 Zineb
000137-30-4 Ziram
1

Includes radiofrequency electromagnetic fields from wireless phones

Last update: 7 April 2015

35

Volume

Year

3
3
3
3
3
2B
3
3

47, 71
16, Sup 7
16, Sup 7
8, Sup 7
8, Sup 7
76
12, Sup 7
68

1999
1987
1987
1987
1987
2000
1987
1997

2B
3
3

76
12, Sup 7
Sup 7, 53

2000
1987
1991