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Pathophysiology of Hyspopadias and Epispadias PDF

This document discusses congenital defects that can occur during genital development between 5-20 weeks of gestation. Epispadias occurs when the urethra develops too far anteriorly, resulting in an opening on the upper surface of the penis or anterior vaginal wall. Hypospadias occurs when the urethral opening is on the underside of the penis rather than at the tip. These defects can cause problems like infections, deformities, or impaired reproductive functions. Proper development involves genitals developing into male or female forms through hormonal influences like testosterone between 8-20 weeks of gestation.

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Charlaine Gripal Sudla
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544 views3 pages

Pathophysiology of Hyspopadias and Epispadias PDF

This document discusses congenital defects that can occur during genital development between 5-20 weeks of gestation. Epispadias occurs when the urethra develops too far anteriorly, resulting in an opening on the upper surface of the penis or anterior vaginal wall. Hypospadias occurs when the urethral opening is on the underside of the penis rather than at the tip. These defects can cause problems like infections, deformities, or impaired reproductive functions. Proper development involves genitals developing into male or female forms through hormonal influences like testosterone between 8-20 weeks of gestation.

Uploaded by

Charlaine Gripal Sudla
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Takes place between 5th and 8 weeks

of gestation

Primordial genitalia in the absence


of hormonal stimulation

Genital tubercle grows in posterior


direction during 6th week of gestation

EPISPADIAS occur when a portion of posterior


bladder wall protrudes through a defect in the
lower abdominal and anterior bladder wall.

can cause impotentia coundi, May cause in frequent ascending can cause impotentia generandi,
which results from the dorsal infections to the prostate or which results from the
curvature of the penile shaft bladder, kidneys and physiological incomplete urethra
problem related to the deformity

In females it occurs at 5th to 8th week


of gestation (Genital tubercle)

Through the stimulation of hormone (estrogen)


the external genitalia were formed

Clitoris, vestibule and labia minora were formed

Hypospadias takes place when there is opening of


urethra in the anterior vaginal wall
In 13 th week of gestation where formation of the
urethra takes place which is situated in the
anterior to the vagina Epispadias takes place when the urethra
developed too far anteriorly
Occur during 8th and 20th weeks of
gestation

Congenital defect that occur


embryologically

8th weeks of gestation, the genital


structures are identical in males and
females

Genitals develop a masculine


phenotype in males primarily under
the influence of testosterone

Anterior or granular urethra Hypospadias occur when there is Prepuce normally forms as
develop in a proximal abnormality in which urethral meatus ridge of the skin from the
direction is located on the ventral aspect of the corona that grows
penis proximal to the tips of the glans circumferentially fusing with
penis which splayed open glans

Ectodermal core forming at


the tip of glans penis, which
canalizes more proximal Urethral folds coalesce in the midline
urethra at the level of from the base to tip, forming
corona turbulized penile urethra and median
scrotal raphe

Failure of fusion of the urethral folds in the hyspopadias impedes this process, and a dorsal
hooded prepuce results
Complications of phismosis:
1. Local infection
2. Prepuceal calculi
3. Paraphismosis
4. Obstruction to urine flow such as hydroureter and hydronephrosis
5. Balanitis
6. Posthitis
7. Penile carcinoma

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