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Gentamicin Dosage Guidelines for Children

The daily dosage of gentamicin is 2-5 mg/kg administered in divided doses every 8 hours, with the standard adult dose being 100 ml over 20 minutes every 8 hours. Treatment should not exceed 7 days except for serious infections in neonates or compromised patients, where higher doses may be needed. The dosage and interval may be modified for impaired renal function to keep pre-dose concentrations below 2 mg/L.

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Fazle Rabbi 173-29-1103
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56 views2 pages

Gentamicin Dosage Guidelines for Children

The daily dosage of gentamicin is 2-5 mg/kg administered in divided doses every 8 hours, with the standard adult dose being 100 ml over 20 minutes every 8 hours. Treatment should not exceed 7 days except for serious infections in neonates or compromised patients, where higher doses may be needed. The dosage and interval may be modified for impaired renal function to keep pre-dose concentrations below 2 mg/L.

Uploaded by

Fazle Rabbi 173-29-1103
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Dosage

The daily dose is 2-5 mg/kg in divided doses every 8 hours. The standard adult dose is 100 ml to
be administered over 20 minutes, 8 hourly or as prescribed by the physician. Whenever
possible treatment should not exceed 7 days. Higher doses are occasionally indicated for
serious infections, especially in the neonates or the compromised hosts. The interval between
doses and even the dose itself may be modified if there is impairment of renal function or high
pre-dose plasma concentration (pre-dose 'trough' concentration should be less than 2 mg/L).

Child:
 Up to 2 weeks: 3 mg/kg every 12 hours
 2 weeks-12 years: 2 mg/kg every 8 hours

Indications
 Gentamicin is indicated in the following conditions:
 Septicemia and neonatal sepsis
 Meningitis and other CNS infections
 Serious bacterial infections of Urinary tract, Respiratory tract, Gastrointestinal tract
(including peritonitis), Skin, Bone & Soft tissue (including Burns)
 Biliary tract infections
 Acute pyelonephritis or prostatitis
 Endocarditis caused by Strep. viridans or Strep. faecalis
 Pneumonia in hospital patient
 Adjunct in listerial meningitis
 Brucellosis, Cat scratch disease, Cystic fibrosis, Endometritis, Listeriosis, Otitis media ,
Otitis externa, Peritonitis, Plague
 Prophylaxis of surgical infections and the treatment of immunocompromised patients
and those in intensive care

Adverse effects
Vestibular and auditory damage, nephrotoxicity, rarely hypomagnesaemia on prolonged
therapy, pseudomembranous colitis, neuromuscular blockade, blood dyscrasia.

Interaction
Aminoglycosides should not be given with potentially ototoxic diuretics (e.g. frusemide and
ethacrynic acid). Concurrent use of other nephrotoxic drugs including other aminoglycosides,
vancomycin and some of the cephalosporins may increase the risk of toxicity. Care is also
required if other drugs with a neuromuscular blocking action are given concomitantly.
Contraindications
Hypersensitivity to Gentamicin, pregnancy, myasthenia gravis.

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