HRAC Mode of Action Classification 2021

Light Activation of ROSa Cellular Metabolism Cell Division and Growth

Inhibition of Inhibition of Inhibition of Microtubule
2 3 23
Inhibition of Photosynthesis at PS II Acetolactate Synthase Microtubule Assembly Organization

5 D1 Serine 264 binders (and

other non-histidine 215 binders) Imidazolinone Sulfonylurea
Triazinones Benefin/
benfluralin Oryzalin Dinitroanilines Barban

Uracils Imazamethaben Foram- Primisulfuron- Thifensulfuron-

z-methyl ① Imazaquin Chlorsulfuron sulfuron methyl methyl Ethalfluralin Trifluralin
②
Triazines Ametryne Prometon
Terbu-
thylazine Bromacil Phenylcarbamates Azimsulfuron
Ethoxy- Metazo- Sulfometuron- Pendi-
Imazapic sulfuron sulfuron methyl Bispyribac-Na Butralin methalin Carbetamide
Desmedi- ②
Cyanazine Propazine Hexazinone pham Propyzamide/
Imazamox Imazethapyr Cinosulfuron
Halosulfuron-
methyl
Propyri-
sulfuron
Trifloxysulfuron
-Na
Pyriminobac-
methyl ① Prodiamine pronamide Carbamates Chlor-
propham

Atrazine Prometryne Terbutryne Lenacil Bensulfuron- Flaza- Metsulfuron- Sulfosulfuron Pyribenzoxim① Chlorthaldi-
Imazapyr methyl sulfuron methyl Dithiopyr methyl/DCPA
Dimetha- Phenmedi-
metryn D1 Histidine
Simazine Metamitron pham
6 215 binders
Cloransulam-
methyl
Amido-
sulfuron
Cyclo-
sulfamuron
Imazo-
sulfuron Prosulfuron
Triflusulfuron-
methyl
Pyrithiobac-
Na Butamifos
Chloro-
toluron Linuron Monuron Terbacil Amides Chlorimuron- Fluceto-
Flumetsulam ethyl sulfuron Nicosulfuron Triasulfuron Pyriftalid Pyrimidinyl benzoates Thiazopyr DMPA
②
Methabenz Chloranocryl/ Ethametsulfuron-
Fluometuron dicryl Flucarbazone- Iodosulfuron- Pyrazosulfuron-
thiazuron Metribuzin
Diclosulam Na
methyl methyl-Na ethyl Tritosulfuron Phosphoroamidates
②
Meto- Amicarbazone ②
Diuron bromuron Tebuthiuron Nitriles Propoxy- Flupyrsulfuron- Ortho- Tribenuron- Pyridines
Chloridazon/
also uncouplers
②
Metosulam carbazone-Na methyl-Na sulfamuron methyl ① Triafamone①
24 Uncouplers
Ureas Isoproturon pyrazon Propanil Thiencarbazone-
methyl Mesosulfuron-
Sulfonanilides
Bromoxynil Bentazon Florasulam Pyroxsulam methyl Rimsulfuron Pyrimisulfan

Auxin
Pyridate ① Penoxsulam Triazolinones 4 Mimics Dinitrophenols DNOC
Ioxynil Triazolopyrimidine – type 1 Triazolopyrimidine – type 2
Dinoseb
Pyridine-carboxylates

Flor-
Inhibition of Inhibition of Glutamine Inhibition of Acetyl Inhibition of Very Long-Chain Inhibition of Fatty Acid Dichlorprop pyrauxifen Fluroxypyr

14 10 1 15 Fatty Acid Synthesis 30 Thioesterase

Protoporphyrinogen Oxidase Synthetase CoA Carboxylase 2,4,5-T Aminopyralid Picloram

MCPA Halauxifen Triclopyr Pyridyloxy-carboxylates

Cyclohexanediones
N-Phenyl-imides Phosphinic acids
α-Chloroacetamides 2,4-D Clopyralid Chloramben
②
Bialaphos/ ②
Flumiclorac- bilanafos ①
pentyl PS l Electron Dimethen- Quinclorac also Benzoates
Pyraflufen-
22 Diversion Clethodim Tepraloxydim
Acetochlor amid Pretilachlor Cinmethylin MCPB ① cellulose syn
②
Dicamba

Butafenacil Pentoxazone ethyl Aminocyclo-

Butachlor Metolachlor Thenylchlor 2,4-DB ① pyrachlor Quinmerac Quinoline-carboxylates
②
Glufosinate- Profoxydim
Flumioxazin Tiafenacil ammonium Benazolin-
Alachlor Metazachlor Propachlor Benzyl ethers Methiozolin Mecoprop ethyl ①
Cycloxydim Tralkoxydim
Cinidon-
ethyl Saflufenacil Pyraclonil
Pyridiniums
Dimethachlor Pethoxamid Propisochlor Clomeprop①
Fluthiacet- Trifludi- Sethoxydim
methyl① moxazin Diquat Thiobencarb/ Auxin Transport
33 Inhibition of Homogentisate Clodinafop-
propargyl ①
Haloxyfop-
methyl ①
Cycloate Benthiocarb Anilofos Phenoxy-carboxylates 19 Inhibitors
Sulfen-
Acifluorfen Oxyfluorfen trazone Solanesyltransferase Esprocarb Vernolate Piperophos α-Thioacetamides
Fenoxaprop-
ethyl ①
Fomesafen
Carfentrazone-
ethyl Paraquat Ø Unknown Mode
Dimepiperate Tri-allate ① Mefenacet
②
Cyhalofop-
Metamifop ① of Action Aryl-carboxylates
butyl ①
Bifenox Azafenidin Oxadiazon
Molinate Cafenstrole Flufenacet α-Oxyacetamides
Fenthiaprop Naptalam
Diphenyl ethers Lactofen Oxadiargyl N-Phenyl-oxadiazolones
EPTC Benfuresate Indanofan Diflu-
Diclofop- Quizalofop-
Fosamine fenzopyr
Cyclopyrimorate ① methyl ① ethyl ①
N-Phenyl-triazolinones Oxiranes
②
Fluazifop-
Thiocarbamates Orbencarb Fentrazamide Tridiphane Dymron/
Cumyluron daimuron Diphenamid
butyl ①
Etho- Fenoxa-
fumesate sulfone Oxazi-
Inhibition of Hydroxyphenyl Inhibition of Solanesyl Aryloxphenoxy-propionates Bensulide clomefone
27 Pyruvate Dioxygenase
32 Diphosphate Synthase
Pinoxaden ①
Prosulfocarb
Ipfen- Pyroxa-
Isoxazolines
DSMA

carbazone sulfone
Difenzoquat Etobenzanid Naproanilide

Benzofuranes Azolyl-carboxamides Bromobutide Pelargonic

MSMA acid
Inhibition of Phytoene ②

Triketones 12 Desaturase Pyributicarb Flamprop-m ① Napropamide

Isoxaflutole ① Aclonifen Inhibition of Cellulose Inhibition of Serine Threonine Inhibition of Enolpyruvyl

29 Synthesis
31 Protein Phosphatase
9 Shikimate Phosphate Synthase
Fenquino-
Phenyl-ethers Legacy Legacy
trione HRAC HRAC
HRAC HRAC
Benzo-
bicyclon ① Tembotrione Diflufenican 1 A Inhibition of ACCase 19 P Auxin transport inhibitors
Inhibition of Deoxy-D-Xyulose ② ②

Mesotrione Beflu- 13 Phosphate Synthase

Alkylazines 2 B Inhibition of ALS 22 D PS l electron diversion
butamid Inhibition of microtubule 23 K2 Inhibition of microtubule organization
3 K1
Indaziflam Endothall Glyphosate assembly 24 M Uncouplers
Bicyclopyrone Tefuryltrione Picolinafen
4 O Auxin mimics
27 F2 Inhibition of HPPD
Sulcotrione
Fluro-
chloridone Isoxazolidinones Triaziflam
5 C1,2
Inhibition of photosynthesis
Inhibition of dihydroorotate
PS ll – Serine 264 28 none
Nitriles Chlorthiamid
dehydrogenase
Benzofenap ① Tolpyralate① N-Phenyl heterocycles Bixlozone ① Inhibition of Dihydroorotate Inhibition of Inhibition of photosynthesis
Norflurazon
② 28 Dehydrogenase
18 Dihydropteroate Synthase
6 C3
PS ll – Histidine 215
29 L Inhibition of cellulose synthesis
Pyrazolynate① Dichlobenil
9 G Inhibition of EPSP synthase 30 Q Inhibition of fatty acid thioesterase
Fluridone
②

Inhibition of glutamine Inhibition of serine threonine

10 H 31 R
Pyrasulfotole Topramezone Flurtamone Diphenyl heterocycles Clomazone ①
Isoxaben
synthetase protein phosphatase
Inhibition of solanesyl
②

Flupoxam 12 F1 Inhibition of PDS 32 S

Pyrazoxyfen① diphosphate synthase
②
13 F4 Inhibition of DOXP synthase Inhibition of homogentisate
Pyrazoles Inhibition of Asulam 33 T
34 14 E Inhibition of PPO solanesyltransferase
Lycopene Cyclase Amitrole
Tetflupyrolimet
15 K3 Inhibition of VLCFAs 34 F3 Inhibition of lycopene cyclase
a
Reactive oxygen species
① Indicates pro-herbicide
18 I DHP inhibition Ø Z Unknown mode of action
② HRAC’s recommendation is not to include a chemical family name when there is one active in the family. Actives without chemical family names are indicated with a white background
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