Class Notes – Biology 101: Foundations of Life
Date: June 26, 2025
Topic: Cellular Respiration
Purpose of Cellular Respiration:
Process by which cells convert glucose into ATP (adenosine triphosphate)
ATP = usable energy for cellular processes
Occurs in both plants and animals
Overall Equation:
C₆H₁₂O₆ + 6O₂ → 6CO₂ + 6H₂O + ATP (≈36–38 molecules)
Three Main Stages of Cellular Respiration:
Glycolysis
Location: Cytoplasm
Anaerobic (does not require oxygen)
Glucose (6C) → 2 Pyruvate (3C)
Produces:
2 ATP (net gain)
2 NADH
Krebs Cycle (Citric Acid Cycle)
Location: Mitochondrial Matrix
Aerobic (requires oxygen indirectly via ETC)
Pyruvate → Acetyl-CoA → Series of reactions
Produces (per glucose):
2 ATP
6 NADH
2 FADH₂
CO₂ as waste
Electron Transport Chain (ETC) & Oxidative Phosphorylation
Location: Inner mitochondrial membrane
Uses NADH & FADH₂ to pump protons, create gradient
Final electron acceptor = O₂ → H₂O
Produces: ~32–34 ATP
Anaerobic Respiration / Fermentation:
Happens when no oxygen is present
Only glycolysis occurs
Pyruvate converted into lactic acid (animals) or ethanol + CO₂ (yeast)
Produces only 2 ATP
Quick Review – ATP Yield:
Stage ATP Produced
Glycolysis 2
Krebs Cycle 2
ETC 32–34
Total ~36–38
Key Takeaways:
Most ATP is made in the mitochondria, during the ETC
Oxygen is essential for full ATP production
Without oxygen, cells rely on less efficient fermentation