Gentamicin 2024

Newborn use only

Alert The administration of antibiotics within 1 hour of the identification of sepsis is recommended. 1
New South Wales Antimicrobial Stewardship category: Restricted after 72 hours.
*Literature reports indicate that the antibiotic activity of some aminoglycosides may be impaired by
beta-lactam antibiotics. ANMF consensus: Where feasible, give at separate sites or separate the
administration time of gentamicin and beta-lactams (penicillin or cephalosporin).
Unregistered products from overseas available during shortages may contain preservatives.
Indication Treatment of gram-negative infections.
Action Bactericidal agent that acts by inhibiting protein synthesis in susceptible bacteria.
Drug type Aminoglycoside antibiotic
Trade name DBL gentamicin, Gentamicin BP (Pfizer)
Presentation 10 mg/mL ampoule – paediatric strength
80 mg/2 mL ampoule – adult strength
NOTE: SAS product may be considered in the event of a shortage. Consult the local pharmacy.
Dose Dose: 5 mg/kg as follows:2-5
Corrected Gestational Drug concentration to
Route Dosing interval
Age/Postmenstrual Age* be performed at:
22 hours after the 2nd
< 30+0 weeks* IV/IM 48 hourly
dose
22 hours after the 2nd
30+0─34+6 weeks* IV/IM 36 hourly
dose
22 hours after the 2nd
≥ 35+0 weeks* IV/IM 24 hourly
dose
Extend dosing interval
*Concurrent cyclo-oxygenase
by 12 hours
inhibitors (indomethacin or IV/IM
Example:
ibuprofen) (6-8)
48 hourly to 60 hourly
Therapeutic hypothermia (9- Trough concentrations
IV/IM 36 hourly
13) prior to every dose

Subsequent dose interval is based on a gentamicin concentration at 22 hours after the administration
of the 2nd dose as indicated in the table below.3,4

22-hour Gentamicin concentration* Interval

≤ 1.2 mg/L Every 24 hours after previous dose
1.3 mg/L ─ 2.6 mg/L Every 36 hours after previous dose
2.7 mg/L ─ 3.5 mg/L Every 48 hours after previous dose
≥ 3.6 mg/L Hold dose, repeat concentration 24 hours later
*Different to trough concentration performed prior to next dose – Refer to dose adjustment section.

Gentamicin monitoring is required ONCE only, except when the duration of gentamicin therapy is
greater than 7 days or with the conditions described in dose adjustment and monitoring section.
Dose adjustment Therapeutic hypothermia –36 hourly interval.9-13 Measure trough concentrations before every dose.
ECMO - Renal dysfunction is the main determinant. Measure trough concentration before 2 nd dose.14
Renal impairment – Measure trough concentration before every dose.
Hepatic impairment – No specific dose adjustment.
Maximum dose
Total cumulative
dose
Route IV
IM – only if IV access is not available.
Preparation 10mg/mL – paediatric strength
Draw up 1mL (10mg) gentamicin and add to 4mL of sodium chloride 0.9% to make a final volume of 5mL
with a concentration of 2mg/mL solution.

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 Gentamicin 2024
Newborn use only

80mg/2 mL – adult strength

Draw up 1mL (40mg) gentamicin and add to 19mL of sodium chloride 0.9% to make a final volume of
20mL with a concentration of 2mg/mL solution.
Administration First dose - IV bolus over 5 minutes. 1,15,36,37,38,39 Subsequent doses can be administered over 5-30
minutes.3,4,16,36
IM- only given when IV route is not available as the IM absorption is variable. Administer required dose
undiluted, deeply into anterolateral thigh muscle.
Monitoring Urine output, urine analysis, blood urea, nitrogen and creatinine
Monitor for anaphylaxis.
Trough concentrations – Target trough concentration: <2 mg/L. Repeat trough concentrations are not
required routinely unless:4
(1) duration of therapy is ≥ 7 days – In this scenario, prior to dose on day 7 and then weekly
thereafter.
(2) renal impairment or perinatal hypoxia with Apgar <5 at 5 minutes and/or concomitant use
of other nephrotoxic agents or therapeutic hypothermia.
(3) In these scenarios, perform trough concentration prior to every dose.

If trough concentration ≥2 mg/L, withhold the dose, repeat trough concentrations before the subsequent
dosing and discuss with infectious disease specialist/clinical microbiologist for either extended dosing
interval or alternate antibiotic.

Peak concentrations - Not required routinely. Target peak concentrations: 5-12 mg/L. Peak concentration
should be drawn at 30 minutes post dose.
Contraindications Hypersensitivity to aminoglycosides
Precautions CAUTION in patients with pre-existing renal impairment, auditory or vestibular impairment,
hypocalcaemia, depressed neuromuscular transmission.
Drug interactions Gentamicin should not be mixed with penicillins or cephalosporins as inactivation occurs. 15
Refer to alert section for further information.
Avoid use with other potent diuretics, neurotoxic, nephrotoxic and neuromuscular blocking agents. 16
Adverse Toxicity is rare in the newborn but can include:
reactions 1. Nephrotoxicity: Associated with excessive accumulation of gentamicin. The initial symptoms may be
due to renal tubular concentrating defect. These include excessive losses of sodium, calcium and
magnesium. This may progress to proteinuria, increased urea, oliguria, increased serum creatinine. Renal
impairment is usually reversible.
2. Ototoxicity: Primarily vestibular but also auditory toxicity. Associated with excessive accumulation of
gentamicin and duration of therapy. Effects often irreversible.
3. Neuromuscular blockade: Muscular paralysis and respiratory failure may occur particularly when used
with other neuromuscular blockers such as pancuronium.
4. Hypersensitivity: Very rare − rash, urticaria, fever, laryngeal oedema, eosinophilia.
Nephrotoxicity and ototoxicity are more pronounced with addition of other nephrotoxic/ototoxic agents
such as furosemide and vancomycin.
Overdose In adults, peritoneal dialysis or haemodialysis will aid in the removal of gentamicin from the blood. This is
particularly important in patients with renal malfunction. 16 No specific information is available for
neonates. For information on the management of overdose, contact the Poisons Information Centre on
13 11 26 (Australia).
Compatibility Fluids: Glucose 5%, glucose 10%, sodium chloride 0.9%,

Y-Site: Alprostadil, amino acid solutions, amifostine, amikacin, amiodarone, ampicillin, anidulafungin,
atracurium, aztreonam, benzylpenicillin, bivalirudin, calcium chloride, calcium gluconate, caspofungin,
cefazolin, cefepime, cefotaxime, ciprofloxacin, cisatracurium, clindamycin, dexmedetomidine, digoxin,
dobutamine, epoetin alfa, ertapenem, esmolol, fentanyl, fluconazole, foscarnet, granisetron,
hydromorphone, labetalol, linezolid, magnesium sulfate, meropenem, methylprednisolone,
metronidazole, midazolam, morphine sulfate, octreotide, pancuronium, paracetamol, penicillin G*,

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 Gentamicin 2024
Newborn use only

phenobarbital sodium, potassium chloride, remifentanil, rocuronium, suxamethonium, tigecycline,

vancomycin, vecuronium, zidovudine.
* Literature reports indicate that the antibiotic activity of some aminoglycosides may be impaired by
beta-lactam antibiotics.
Incompatibility Fluids: Fat emulsions.

Y-site: Amphotericin, azathioprine, azithromycin, chloramphenicol, dexamethasone, diazepam, diazoxide,

flucloxacillin, folic acid, furosemide (frusemide), ganciclovir, heparin sodium, hydrocortisone,
indomethacin, insulin, pentamidine, phenytoin, propofol, teicoplanin.
Stability Administer immediately, discard unused portion.
Storage Protect from light. Store below 25°C
Excipients DBL Gentamicin: Disodium edetate
Pfizer Gentamicin: Disodium edetate, sodium hydroxide, sulfuric acid.
Special
comments
Evidence Efficacy
Extended interval dosing for gentamicin in neonates provides a superior pharmacokinetic profile
compared to multiple doses a day dosing. However, there is insufficient evidence to conclude whether a
'once a day' or a 'multiple doses a day' regimen of gentamicin is clinically superior in treating proven
neonatal sepsis.17,18

Current dosing recommendations are based on 4 prospective observational studies using extended-
interval dosing interval with a single drug concentration at 22 hours after the first dose. 2-5 Three of them
were consecutive Canadian studies. First of the studies evaluated the extended interval dosing (EID)
regimen in neonates ≤28-week gestation. The dosing interval was based on a 22 h level after the first
dose of 5mg⁄kg. All neonates, except one, achieved therapeutic peak and trough levels. Based on the 22
h level, dosing interval was 36 h in 61% of neonates and 48 h in 39% of neonates. In their second
prospective, observational study, similar findings were noted in 104 neonates ≤7 days of life, gestational
age 23 weeks to full term. Appropriate peak and trough concentrations were attained in all neonates. A
third prospective observational study by the group assessed extended-interval dosing of gentamicin in
neonates >7 days old and found appropriate peak and trough concentrations in all neonates. 2-4 Fourth
observational study by Matinkova et al, in which 4 mg/kg/dose was given at various intervals based on
gestational age groups (<34 weeks-48 hourly; 34-38 weeks – 36 hourly; >38 weeks – 24 hourly). The
initial dose of gentamicin 4mg/kg during the first week of life was high enough to reach bactericidal Cmax
within 6–10mg/L. However, Cmax <6 mg/L occurred in 13% of neonates. The inter-dose interval modified
according to the recommendation resulted in Ctrough values within the target range of 0.5–2.0mg/L in all
but 2 neonates.5

Patients who have early (l-hr post-infusion) peak plasma aminoglycoside levels that are >5 ug/mL for
gentamicin and tobramycin and >20 ug/ml for amikacin are less likely to die from gram-negative
bacteraemia. Moore et al reported a 2.4% mortality rate in adults who achieved 1-hour post-infusion
gentamicin or tobramycin peak concentrations above 5 μg/mL. Mortality rate increased to 20.9% for
patients failing to achieve peak concentrations above 5 μg/mL within 24–48 hours of starting therapy.19,20
Therapeutic hypothermia (TH): Gentamicin clearance is decreased in neonates receiving hypothermia
treatment. Modified gentamicin dosing regimens are required to avoid potential toxicity related to
higher concentrations.13
ECMO: During ECMO, gentamicin has an increased volume of distribution (Vd), and decreased clearance
(Cl), leading to a prolonged elimination half-life. The renal dysfunction, which is a common multifactorial
condition during ECMO, can be considered as the main determinant of the prolonged elimination half-life
of gentamicin. Given the concentration dependent antimicrobial activity of aminoglycosides, it is
recommended to perform therapeutic drug monitoring (TDM) to ensure adequate antimicrobial
exposure.14
Cyclo-oxygenase inhibitors: Renal drug clearance of aminoglycosides is lower in infants on cyclo-
oxygenase inhibitors.6-8

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 Gentamicin 2024
Newborn use only

IV administration – bolus versus infusion: While the manufacturer recommendation is to infuse the dose
over 30 minutes or more, IV push administration provides clinical and practical advantages over longer IV
infusions in multiple case scenarios including the first dose to treat sepsis promptly. Gentamicin has
primary literature data to support IV push administration. 1,15,36,37,38,39
Safety
Ototoxicity: There is no clear association between peak or trough levels and ototoxicity in neonates.21-23
The chance of gentamicin ototoxicity is reported to be greater in those who receive the drug for a longer
duration.21
Nephrotoxicity: Nephrotoxicity does not seem to be related to peak or trough levels and more related to
drug concentration and longer duration.24 Among neonates with PDA and receiving gentamicin, non-
steroid anti-inflammatory drugs (ibuprofen, indomethacin) therapy increases the risk of acute kidney
injury.25
MT-RNR1 genotype: MT-RNR1 gene mutation is one of the common causes of hereditary hearing loss,
particularly in Asian population. In individuals who carry mutations in MT-RNR1 gene, a single dose of
gentamicin can result in hearing loss.26,27
Intraventricular antibiotics: In infants with meningitis and ventriculitis, intraventricular antibiotics in
combination resulted in a three‐fold increase in mortality compared to standard treatment with
intravenous antibiotics alone and should be avoided. 28
Pharmacokinetics
Aminoglycosides display concentration-dependent killing, suggesting higher peaks provide greater
efficacy.29,30 While a peak aminoglycoside concentration to minimum inhibitory concentration (MIC) ratio
of 8–10:1 is considered ideal, based on the usual MICs of Escherichia coli (range 0.25–1 mg/L) a peak of
at least 5 mg/L has a high likelihood of being effective.(4, 30) Aminoglycosides display a post-antibiotic
effect whereby bacterial growth is suppressed despite negligible drug concentrations. 31 Aminoglycosides
have poor CNS penetration when administered intravenously. 32
Practice points Dose
There is insufficient evidence whether a 'once a day' regimen of gentamicin is optimal in treating proven
neonatal sepsis, however, pharmacokinetic data suggests 'once a day' gentamicin regimens are superior
to a 'multiple doses a day' regimens.17 (LOE I, GOR B)
The recommended dose regimen in this formulary is a pragmatic adaptation of the dosing used in 4
prospective observational studies.2-5 (LOE III-3, GOR B)
Dose adjustment
An increased dosing interval is recommended in therapeutic hypothermia. 9-13 (LOE IV, GOR B)
An increased dosing interval is recommended in infants on cyclo-oxygenase inhibitors.6 (LOE IV, GOR B)
Monitoring
The evidence suggests a serum gentamicin concentration performed 22 hours after the 1st dose is useful
to guide dosing intervals.2-4(LOE III-3, GOR B). However, in daily practice, gentamicin is most often
discontinued within 36-48 hours of commencement (once the neonate is deemed no longer at risk of
sepsis and septic screen remain negative). Therefore, measurement of drug concentrations is
recommended only after the 2nd dose to limit the burden of blood sampling. (ANMF consensus).
Subsequent concentrations are not routinely required.2-4 (LOE III-3, GOR B)
Routine peak concentrations are not necessary as high dose extended interval dosing regimens are able
to achieve target peak concentrations in the majority of infants.2-4,17,18 (LOE III-3, GOR B)
Consider performing peak concentrations if there is poor clinical response in gram negative infections,
oedema or macrosomia.5 (LOE IV, GOR C).
A peak concentration, if required, can be performed after the 2nd or 3rd dose. 29
Target peak concentrations of 5─12 mg/L. 17-19,29 (LOE IV, GOR C)
Target trough concentrations of < 2 mg/L to reduce risk of ototoxicity and nephrotoxicity. 33,34 (LOE IV,
GOR C - adult)
Duration of therapy ≥ 7 days – Perform trough concentration prior to dose on day 7 and then weekly
thereafter.4,35 (LOE IV, GOR B)
Perinatal hypoxia – Perform trough concentrations prior to every dose.4,35 (LOE IV, GOR B)
Renal impairment – Perform trough concentrations prior to every dose.4,35 (LOE IV, GOR B)

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 Gentamicin 2024
Newborn use only

Concomitant use of other nephrotoxic agents – Perform trough concentrations prior to every dose.4,35
(LOE IV, GOR B)
ECMO – Perform trough concentration before 2nd dose.14 (LOE IV, GOR B)
Route
Intraventricular antibiotics are associated with increased mortality and should be avoided. 28 (LOE II, GOR
B)
General
Aim to minimise aminoglycoside toxicity by (1) avoiding gentamicin to patients at elevated risk (i.e. on
indomethacin, history of hypoxia and/or significant renal dysfunction), (2) minimising the duration of
treatment and (3) prescribing a dose in a way that minimizes risk (i.e. EID with dose adjustment as
necessary). (ANMF consensus)
References 1. https://www.cec.health.nsw.gov.au/keep-patients-safe/sepsis/sepsis-pathways. Released February
2024. Accessed online on 19 April 2024.
2. Alshaikh B, Dersch-Mills D, Taylor R, Akierman AR, Yusuf K. Extended interval dosing of gentamicin in
premature neonates ≤ 28-week gestation. Acta Paediatrica. 2012;101(11):1134-9.
3. Dersch-Mills D, Akierman A, Alshaikh B, Yusuf K. Validation of a Dosage Individualization Table for
Extended-Interval Gentamicin in Neonates. Annals of Pharmacotherapy. 2012;46(7-8):935-42.
4. Dersch-Mills D, Akierman A, Alshaikh B, Sundaram A, Yusuf K. Performance of a dosage
individualization table for extended interval gentamicin in neonates beyond the first week of life. The
Journal of Maternal-Fetal & Neonatal Medicine. 2016;29(9):1451-6.
5. Martínková J, Pokorná P, Záhora J, Chládek J, Vobruba V, Selke-Krulichová I, et al. Tolerability and
outcomes of kinetically guided therapy with gentamicin in critically ill neonates during the first week
of life: an open-label, prospective study. Clinical therapeutics. 2010;32(14):2400-14.
6. Allegaert K. The impact of ibuprofen or indomethacin on renal drug clearance in neonates. The
Journal of Maternal-Fetal & Neonatal Medicine. 2009;22(sup3):88-91.
7. Smits A, De Cock RFW, Allegaert K, Vanhaesebrouck S, Danhof M, Knibbe CAJ. Prospective Evaluation
of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice.
Antimicrobial Agents and Chemotherapy. 2015;59(10):6344.
8. Smits A, Kulo A, Van Den Anker J, Allegaert K. The amikacin research program: a stepwise approach to
validate dosing regimens in neonates. 2016:1-10.
9. Frymoyer A, Lee S, Bonifacio SL, Meng L, Lucas SS, Guglielmo BJ, et al. Every 36-h gentamicin dosing in
neonates with hypoxic–ischemic encephalopathy receiving hypothermia. Journal of Perinatology.
2013;33(10):778-82.
10. Bijleveld YA, De Haan TR, Van Der Lee HJH, Groenendaal F, Dijk PH, Van Heijst A, et al. Altered
gentamicin pharmacokinetics in term neonates undergoing controlled hypothermia. British Journal of
Clinical Pharmacology. 2016;81(6):1067-77.
11. Lutz IC, Allegaert K, de Hoon JN, Marynissen H. Pharmacokinetics during therapeutic hypothermia for
neonatal hypoxic ischaemic encephalopathy: a literature review. BMJ Paediatr Open.
2020;4(1):e000685-e.
12. Cristea S, Smits A, Kulo A, Knibbe CAJ, van Weissenbruch M, Krekels EHJ, et al. Amikacin
Pharmacokinetics To Optimize Dosing in Neonates with Perinatal Asphyxia Treated with Hypothermia.
Antimicrobial Agents and Chemotherapy. 2017;61(12):e01282-17.
13. Choi D, Park J, Lee S, An S. Effect of hypothermia treatment on gentamicin pharmacokinetics in
neonates with hypoxic‐ischaemic encephalopathy: A systematic review and meta‐analysis. Journal of
Clinical Pharmacy and Therapeutics. 2018;43(4):484-92.
14. Raffaeli G, Pokorna P, Allegaert K, Mosca F, Cavallaro G, Wildschut E, et al. Drug disposition and
pharmacotherapy in neonatal ECMO: from fragmented data to integrated knowledge. Frontiers in
pediatrics. 2019;7:360.
15. Spencer S, Ipema H, Hartke P, Krueger C, Rodriguez R, Gross AE, Gabay M. Intravenous push
administration of antibiotics: literature and considerations. Hospital pharmacy. 2018 Jun;53(3):157-
69.

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Newborn use only

16. DBL Gentamicin injection BP. Pfizer Australia Pty Ltd. Accessed online 19 April 2024.
17. Rao SC, Srinivasjois R, Moon K. One dose per day compared to multiple doses per day of gentamicin
for treatment of suspected or proven sepsis in neonates. Cochrane Database of Systematic Reviews.
2016.
18. Nestaas E. Aminoglycoside extended interval dosing in neonates is safe and effective: a meta-analysis.
2005;90(4):F294-f300.
19. Moore RD, Smith CR, Lietman PS. The association of aminoglycoside plasma levels with mortality in
patients with gram-negative bacteremia. Journal of infectious diseases. 1984;149(3):443-8.
20. Moore RD, Smith CR, Lietman PS. Association of aminoglycoside plasma levels with therapeutic
outcome in gram-negative pneumonia. The American journal of medicine. 1984;77(4):657-62.
21. Kent A, Turner MA, Sharland M, Heath PT. Aminoglycoside toxicity in neonates: something to worry
about? Expert Review of Anti-infective Therapy. 2014;12(3):319-31.
22. Setiabudy R, Suwento R, Rundjan L, Yasin FH, Louisa M, Dwijayanti A, et al. Lack of a relationship
between the serum concentration of aminoglycosides and ototoxicity in neonates. Int J Clin
Pharmacol Ther. 2013;51(5):401-6.
23. El-Barbary MN, Ismail RIH, Ibrahim AAA. Gentamicin extended interval regimen and ototoxicity in
neonates. 2015;79(8):1294-8.
24. Quiros Y, Vicente-Vicente L, Morales AI, López-Novoa JM, López-Hernández FJ. An integrative
overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin. Toxicological
sciences. 2011;119(2):245-56.
25. Constance JE, Reith D, Ward R, Balch A, Stockmann C, Korgenski EK, et al. Risk of nonsteroidal anti-
inflammatory drug-associated renal dysfunction among neonates diagnosed with patent ductus
arteriosus and treated with gentamicin. Journal of Perinatology. 2017;37(10):1093-102.
26. Wang X, Hong Y, Cai P, Tang N, Chen Y, Yan T, et al. Rapid and Reliable Detection of Nonsyndromic
Hearing Loss Mutations by Multicolor Melting Curve Analysis. Scientific Reports. 2017;7(1):42894.
27. Dean L. Gentamicin Therapy and MT-RNR1 Genotype: National Center for Biotechnology Information
(US), Bethesda (MD); 2012 2012.
28. Shah SS, Ohlsson A, Shah VS. Intraventricular antibiotics for bacterial meningitis in neonates.
Cochrane Database of Systematic Reviews. 2012(7).
29. Touw DJ, Westerman EM, Sprij AJ. Therapeutic Drug Monitoring of Aminoglycosides in Neonates.
Clinical Pharmacokinetics. 2009;48(2):71-88.
30. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE. Developmental
pharmacology—drug disposition, action, and therapy in infants and children. New England Journal of
Medicine. 2003;349(12):1157-67.
31. Lacy MK, Nicolau DP, Nightingale CH, Quintiliani R. The pharmacodynamics of aminoglycosides.
Clinical infectious diseases. 1998;27(1):23-7.
32. Sullins AK, Abdel-Rahman SM. Pharmacokinetics of antibacterial agents in the CSF of children and
adolescents. Pediatric Drugs. 2013;15(2):93-117.
33. Dahlgren JG, Anderson ET, Hewitt WL. Gentamicin blood levels: a guide to nephrotoxicity.
Antimicrobial agents and chemotherapy. 1975;8(1):58-62.
34. Goodman EL, Van Gelder J, Holmes R, Hull AR, Sanford JP. Prospective comparative study of variable
dosage and variable frequency regimens for administration of gentamicin. Antimicrobial Agents and
Chemotherapy. 1975;8(4):434-8.
35. de Hoog M, Mouton JW, van den Anker JN, editors. New dosing strategies for antibacterial agents in
the neonate. Seminars in Fetal and Neonatal Medicine; 2005: Elsevier.
36. MerativeTM Micromedex® Complete IV Compatibility (electronic version). Merative, Ann Arbor,
Michigan, USA. Available at: https://www.micromedexsolutions.com/ (cited: April/19/2024).
37. Bromiker R, Adelman C, Arad I, Shapiro M, Levi H. Safety of gentamicin administered by intravenous
bolus in the nursery. Clinical pediatrics. 1999 Jul;38(7):433-5.

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Newborn use only

38. Mendelson J, Portnoy J, Dick V, Black M. Safety of the bolus administration of gentamicin.
Antimicrobial Agents and Chemotherapy. 1976 Apr;9(4):633-8.
39. McLean AJ, IoannidesDemos LL, Li SC, Bastone EB, Spicer WJ. Bactericidal effect of gentamicin peak
concentration provides a rationale for administration of bolus doses. Journal of Antimicrobial
Chemotherapy. 1993 Aug 1;32(2):301-5.

VERSION/NUMBER DATE
Original version 1.0 21/10/2015
Version 1.1 23/06/2016
Version 2.0 5/11/2020
Version 3.0 18/02/2021
Current 4.0 24/04/2024
REVIEW 24/04/2029

Authors Contribution of the current version

Author/s Srinivas Bolisetty, Nilkant Phad
Evidence Review Srinivas Bolisetty, Nilkant Phad
Expert review Brendan McMullan, Karel Allegaert
Nursing Review Eszter Jozsa, Benjamin Emerson-Parker
Pharmacy Review Susannah Brew, Rebecca O’Grady
ANMF Group contributors Bhavesh Mehta, Rebecca Barzegar, Mohammad Irfan Azeem, Thao Tran, Helen Huynh, Martin
Kluckow, Michelle Jenkins, Stephanie Halena, Susannah Brew, Simarjit Kaur, Kerryn Houghton,
Natalia Srnic, Bryony Malloy, Renae Gengaroli, Amy Hobday, Corinne Beckman
Final editing Srinivas Bolisetty
Electronic version Cindy Chen, Ian Callander
Facilitator Srinivas Bolisetty

Citation for the current version

Bolisetty S, Phad N, McMullan B, Allegaert K, Jozsa E, Emerson-Parker B, Brew S, O’Grady R, Mehta B, Barzegar
R, Kluckow M, Azeem MI, Chen C, Malloy B, Tran T, Huynh H, Jenkins M, Halena S, Kaur S, Houghton K, Srnic N,
Gengaroli R, Hobday A, Beckman C, Callander I. Gentamicin. Consensus formulary by the Australasian Neonatal
Medicines Formulary group. Version 4, dated 24 April 2024. www.anmfonline.org

ANMF consensus group Gentamicin Page 7 of 7