YEAR OF THE STRENGTHENING OF NATIONAL SOVEREIGNTY

FACULTY: Food Industry Engineering

PROFESSIONAL SCHOOL: INDUSTRIAL ENGINEERING

TEACHER: GIOVANNA CORAL SUAREZ

THEME: APPLICATION OF THE INTEGRAL IN HUMAN MEDICINE

STUDENTS:

- MUÑOZ GUIMAREY DÁNICA ALONDRA

- GUTIÉRREZ AEDO JHONY ERNESTO
- MEJÍA JAMANCA RAUL FERNANDO

COURSE: MATHEMATICS II
Index.................................................................................................................................. 1

Introduction......................................................... 2

Theoretical Framework..................................................................................................................... 3

Application of integral calculus........................................................3

Applied integrals in human medicine ……………………………………………….3

Integration

Gasto cardiaco..................................................................................................................... 4

Mathematical justification...................................................................................................... 5

Conclusions

References........................................................................................................................... 7

Annexes..............................................................8
1 INTRODUCTION

Integral calculus as
mathematical concept is
widely used in the
engineering and
exact sciences, when is
talks about medicine, it would seem
not having a connection
evident among
both topics, medicine to
being a science full of
non-quantifiable variables, the
applications
mathematics have only
torn the medicine,
models of pandemics,
propagation of
diseases, analysis of
heart rate and flow of
blood in the sales among others
they are some
applications of mathematics
in medicine, in the present
work we will focus on the
calculation of cardiac output at
through the injection of a
glucose solution in the catheter
from the
pulmonary artery (method
of tincture dilution
subsequently analyzing
the curve of
termodilution using the
Stewart-Hamilton formula
Integral calculus as
mathematical concept is
widely used in the
engineerings and
exact sciences, when it
talks about medicine, it would seem
to have no connection
evident among
both topics, medicine at
to be a science full of
non-quantifiable variables, the
applications
mathematics have only
tearing the medicine,
pandemic models,
propagation of
diseases, analysis of
heart rate and flow of
blood in sales among others
they are some
applications of mathematics
in medicine, in the present
work we will focus on the
calculation of cardiac output to
through the injection of a
glucose serum in the catheter
of the
pulmonary artery (method)
of dilution of tincture)
later analyzing
the curve of
thermodilution using the
Stewart-Hamilton formula
Integral calculus as
mathematical concept is
widely used in the
engineering and
exact sciences, when they
talks about medicine, it would seem
not having a connection
evident between
both topics, medicine to
to be a science full of
non-quantifiable variables, the
applications
mathematics have only
torn the medicine,
models of pandemics
propagation of
diseases, analysis of
heart rate and flow of
blood in the sales among others
they are some
applications of mathematics
in medicine, in the present
work we will focus on the
calculation of cardiac output to
through the injection of a
glucose solution in the catheter
of the
pulmonary artery (method
of dilution of tincture,
subsequently analyzing
the curve of
thermodilution using the
Stewart-Hamilton formula
Integral calculus as
mathematical concept is
widely used in the
engineering and
exact sciences, when is it
talks about medicine, it would seem
there is no connection
evident among
both themes, medicine to
to be a science full of
non-quantifiable variables, the
applications
mathematics have only
torn the medicine,
pandemic models,
propagation of
diseases, analysis of
heart rate and flow of
blood in sales among others
they are some
applications of mathematics
in medicine, in the present
we will focus on the work
calculation of cardiac output to
through the injection of a
glucose solution in the catheter
of the
pulmonary artery (method
of dilution of tincture,
subsequently analyzing
the curve of
dilution term using the
Stewart-Hamilton formula
The purpose intended to be established with this work is to show the
importance of integral applications in medicine. calculation
Integral as a mathematical concept is widely used in the
engineering and exact sciences, when talking about medicine, it seems not to
there is an evident connection between both topics, medicine being a
science filled with unquantifiable variables, mathematical applications
they have only torn the medicine, models of pandemics, spread
of diseases, analysis of heart rate and blood flow in sales
among others are some applications of mathematics in medicine, in the
In this work, we will focus on the calculation of cardiac output through
the injection of a glucose serum into the artery catheter pulmonary
(dilution method of denture), subsequently analyzing the curve
determination of dilution using the Stewart-Hamilton formula
 Theoretical Framework

1. Application of integral calculus

Through integral calculus, we can propose causes such as speed of

spread of a disease, the reaction speed of a medication and the
cardiac output. CALCULATION OF CARDIAC OUTPUT It is the technique used to
obtain the CO through the pulmonary artery character. the CO is calculated by
analysis of the thermodilution curve using the equation
[Link] applied a the medicine humana theory

Integral calculus, framed within infinitesimal calculus, is a branch of the

mathematics in the process of integration or anti-derivation is very common in the
engineering and in science as well; it is mainly used for calculating areas.
Given a function F(x) of a real variable x and an interval [a, b] of the real line, the
Integral is equal to the area of the region in the xy plane limited by the graph of F, the axis
x and the vertical lines x = a and x = b, where the areas below the axis are negative
x.
3. Integration
The integration consists of the infinite sum of infinitely many addends.
small ones, which corresponds to the operation contrary to the derivative.
Defined geometrically. Given a function f(x), and an interval
delimited by the points a and b, the area bounded by the curve between the
points a and b with the X axis is equal to the integral from point a to point b of the
function f(x).
b

∫ f ( x) dx
a

Definite integral.

Integral calculus is considered the result of the work of Newton and Leibniz.
in which they demonstrate the connection between the derivative and the integral being
Integrals are the opposite process of differentiation, in the same way.
they propose that the result of a definite integral is the subtraction of the
indefinite integral evaluated at point a and the indefinite integral
evaluated at point b. As such, the current notation of the integral is
result of Leibniz's work
b

∫ f ( X ) dx= ∫f ( a ) of− f∫ ( b ) db
a

Result of a definite integral

The integration process allows us to calculate areas of figures.

complete, volume
- solids in revolution, obtaining data from their derivatives,
how to obtain position a
through the integral of the velocity, etc.
The integration process allows us to calculate the areas of figures.
completes, volume of solids in revolution, obtaining data to
Starting from derivatives, how to obtain the position through integration
of the speed, etc.

Cardiac output
 Cardiac output is defined as the amount (in volume) of
blood expelled by the heart in minutes.

Expressed as:

GC (gasto cardiaco) = VS (volumen sistólico) × FC (frecuencia

cardiac

Cardiac Output (CO) expressed in volume per unit

detempo

Regarding the question of medicine, integrals are

commonly used for Academically speaking,
we can locate the normal values of cardiac output in the
healthy adult around 4-6.5 l/min (2.5 l/min per M of
the body surface would be the cardiac index), at rest. Without
embargo, cardiac output, as the main determinant of
oxygen transport to the organism must adapt in each
moment. The stroke volume is defined as the amount of
blood expelled into the aorta or pulmonary artery during the
contraction, being the result of ventricular functions
contractility, contraction synergy, preload and post-load.
While the heart rate is defined as the beats of
heart in a minute

(T¿¿b−T).Vi .Vi k
CO = ¿
∫ ∆Td.t b
Calculation of cardiac output in terms of temperature

EQUATION FOR CALCULATING CARDIAC OUTPUT

Technique used to obtain the GC through the character of the

pulmonary artery. The GC is calculated by analyzing the curve of
dilution term using the equation
 ∞

∫ tracer concentration xdt

0

EQUATION FOR CALCULATING CARDIAC OUTPUT USED BY

THE PiCCO SYSTEM.

CO = gasto cardiaco; Vi= volumen inyectado; Tb = temperatura de

the blood; T1 = marker temperature; K = constant; Tb (t) dt
change in blood temperature as a function of time

Mathematical justification

For the cardiac thermodilution method, after having been

placed the temperature change between the blood
arterial and the tooth can be graphed as a function of time,
that approximately a curve with small variations,
as shown in the image, the which descend
logarithmically it is directed to zero without touching it, due to the
cyclic behavior of the circulatory system that concentration
it will return to that place, being graphed again, but
it would reach zero if the circulatory system were to stop

Because it is necessary to calculate cardiac output (volume of blood that

the heart beats at a determined tempo), it is necessary to know the
temperature is the period of time where the graph changes the fastest, which is
where it goes through the heart. With the given points, it can be approximated to a
function, which is the change in Temperature as a function of time, without
embargo, we need to saber the temperature, not its rate of change or
derivative, so it is necessary to apply the opposite step of deriving, integrating
Regarding the weather. Since it is necessary to know the temperature, this integral
it becomes defined, using the time lapses already described.

CONCLUSION

Through the calculation and the differential equations that are solved with the
integrals, you can pose things like the propagation speed of a
disease, the reaction speed of a medication, the rate of
bacterial population growth, the concentration at a given time
from a mixture that is being stirred, the cooling that a corpse has and so on
determine the time of death, in biology the growths
population areas, the spread of population areas, the flows of rivers,
hydraulic expenses, in medicine the forces of bones, tensions, pressures,
optical methods are also very commonly used, in biochemistry the determinations of the
links are made by spectra that base their areas under the curves to
determine the links, quantum chemistry is based on calculation.
On the other hand, once a mathematical model is built, a
software can process input data and give the result, it is
It is important to be able to understand the functioning of the underlying mathematics.
from the automated processes and thus be able to continue with the exploration
scientific and the development of technology so that we do not get overwhelmed in
creation skills by our own computers. Even so,
exist calculators what they can solve any integral it is of
primordial importance for the professional in the development of new
technologies dominate the functioning of mathematical logics such as
it is integral and differential calculus.

Bibliographic references

- [Link]
integral-calculation-in-medicine-cardiac-expense/

- [Link]
[Link]

- Application of
integral-calculation-in-medicine
- [Link]
integral-in-biological-sciences

ANNEXES