AmiGO 2: Term Details for "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" (GO:0000184)

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Term Information

Accession: GO:0000184
Name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Ontology: biological_process
Synonyms: mRNA breakdown, nonsense-mediated decay, mRNA catabolic process, nonsense-mediated, mRNA catabolism, nonsense-mediated, mRNA degradation, nonsense-mediated decay, nonsense-mediated mRNA decay, nuclear mRNA catabolic process, nonsense-mediated decay
Alternate IDs: None
Definition: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. Source: GOC:krc, PMID:10025395, GOC:ma
Comment: None
History: See term history for GO:0000184 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (excluding "regulates").; Link to all direct and indirect annotations to nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (excluding "regulates").

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0008152 metabolic process
GO:0048519 negative regulation of biological process
GO:0050794 regulation of cellular process
GO:0009058 biosynthetic process
GO:0043170 macromolecule metabolic process
GO:0048523 negative regulation of cellular process
GO:0044238 primary metabolic process
GO:0019222 regulation of metabolic process
GO:0009056 catabolic process
GO:0009059 macromolecule biosynthetic process
GO:0009892 negative regulation of metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009889 regulation of biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0010467 gene expression
GO:0009057 macromolecule catabolic process
GO:0009890 negative regulation of biosynthetic process
GO:0010605 negative regulation of macromolecule metabolic process
GO:0090304 nucleic acid metabolic process
GO:0034655 nucleobase-containing compound catabolic process
GO:0010556 regulation of macromolecule biosynthetic process
GO:0010558 negative regulation of macromolecule biosynthetic process
GO:0141188 nucleic acid catabolic process
GO:0010468 regulation of gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0010629 negative regulation of gene expression
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO:0070479 nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay
GO:2000624 positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Parents of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)

subject	relation	object
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	is_a	nuclear-transcribed mRNA catabolic process (GO:0000956)

Children of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)

subject	relation	object
positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:2000624)	RO:0002213	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay (GO:0070479)	is_a	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:2000622)	RO:0002211	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:2000623)	RO:0002212	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay (GO:0070478)	is_a	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Reactome: R-HSA-927802
Wikipedia: Nonsense-mediated_mRNA_decay; Nonsense-mediated_decay