AmiGO 2: Term Details for "exosome (RNase complex)" (GO:0000178)

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Term Information

Accession: GO:0000178
Name: exosome (RNase complex)
Ontology: cellular_component
Synonyms: exosome (ribonucleasease complex), exosome multienzyme ribonuclease complex
Alternate IDs: None
Definition: A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. Source: PMID:26726035, PMID:17174896, PMID:20531386
Comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
History: See term history for GO:0000178 at QuickGO
Chem. react.: None
Subset: goslim_pir
Related: Link to all genes and gene products annotated to exosome (RNase complex) (excluding "regulates").; Link to all direct and indirect annotations to exosome (RNase complex) (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for exosome (RNase complex) (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
GO:0003824 catalytic activity
CARO:0000000 anatomical entity
GO:0016787 hydrolase activity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
GO:0009058 biosynthetic process
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0016788 hydrolase activity, acting on ester bonds
CARO:0000006 material anatomical entity
GO:0008152 metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0044238 primary metabolic process
GO:0009056 catabolic process
GO:0140098 catalytic activity, acting on RNA
GO:0009987 cellular process
GO:0005575 cellular_component
CARO:0000003 connected anatomical structure
GO:0004527 exonuclease activity
GO:0009059 macromolecule biosynthetic process
GO:0043170 macromolecule metabolic process
UBERON:0000465 material anatomical entity
GO:0003674 molecular_function
GO:0004518 nuclease activity
GO:0090304 nucleic acid metabolic process
GO:0034654 nucleobase-containing compound biosynthetic process
UBERON:0000061 anatomical structure
GO:0005488 binding
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0009057 macromolecule catabolic process
GO:0141187 nucleic acid biosynthetic process
GO:0034655 nucleobase-containing compound catabolic process
GO:0032991 protein-containing complex
GO:0004532 RNA exonuclease activity
GO:0016070 RNA metabolic process
GO:0004540 RNA nuclease activity
GO:0008408 3'-5' exonuclease activity
GO:1902494 catalytic complex
CL:0000000 cell
GO:0110165 cellular anatomical structure
GO:0010467 gene expression
GO:0003676 nucleic acid binding
GO:0141188 nucleic acid catabolic process
GO:0032774 RNA biosynthetic process
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters
GO:0000175 3'-5'-RNA exonuclease activity
GO:1905354 exoribonuclease complex
GO:0005622 intracellular anatomical structure
GO:0003723 RNA binding
GO:0006401 RNA catabolic process
GO:0006396 RNA processing
GO:0000178 exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000176 nuclear exosome (RNase complex)

Parents of exosome (RNase complex) (GO:0000178)

subject	relation	object
exosome (RNase complex)	RO:0002162	cellular organisms (NCBITaxon:131567)
exosome (RNase complex)	RO:0002215	RNA catabolic process (GO:0006401)
exosome (RNase complex)	BFO:0000050	intracellular anatomical structure (GO:0005622)
exosome (RNase complex)	is_a	exoribonuclease complex (GO:1905354)
exosome (RNase complex)	RO:0002215	RNA processing (GO:0006396)
exosome (RNase complex)	RO:0002215	RNA binding (GO:0003723)
exosome (RNase complex)	RO:0002215	3'-5'-RNA exonuclease activity (GO:0000175)

Children of exosome (RNase complex) (GO:0000178)

subject	relation	object
cytoplasmic exosome (RNase complex) (GO:0000177)	is_a	exosome (RNase complex)
nuclear exosome (RNase complex) (GO:0000176)	is_a	exosome (RNase complex)

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