ZNF16

ZNF16
Identifikatori
Aliasi	ZNF16
Vanjski ID-jevi	OMIM: 601262 HomoloGene: 56008 GeneCards: ZNF16
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	144,950,888 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • Jedarce;
Biološki proces	• positive regulation of cell cycle phase transition; • positive regulation of kinase activity; • ćelijski ciklus; • negative regulation of apoptotic process; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of megakaryocyte differentiation; • positive regulation of cell division; • positive regulation of erythrocyte differentiation; • transcription, DNA-templated; • positive regulation of cell population proliferation; • cellular response to sodium dodecyl sulfate; • Ćelijska dioba; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	7564
	n/a
	ENSG00000170631
	n/a
	P17020
	n/a
	NM_001029976; NM_006958
	n/a
	NP_001025147; NP_008889
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Protein cinkovog prsta 16 je protein koji je kod ljudi kodiran genom ZNF16.^[3]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 682 aminokiseline, а molekulska težina 76.472 Da.^[4]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPSLRTRREE	AEMELSVPGP	SPWTPAAQAR	VRDAPAVTHP	GSAACGTPCC
SDTELEAICP	HYQQPDCDTR	TEDKEFLHKE	DIHEDLESQA	EISENYAGDV
SQVPELGDLC	DDVSERDWGV	PEGRRLPQSL	SQEGDFTPAA	MGLLRGPLGE
KDLDCNGFDS	RFSLSPNLMA	CQEIPTEERP	HPYDMGGQSF	QHSVDLTGHE
GVPTAESPLI	CNECGKTFQG	NPDLIQRQIV	HTGEASFMCD	DCGKTFSQNS
VLKNRHRSHM	SEKAYQCSEC	GKAFRGHSDF	SRHQSHHSSE	RPYMCNECGK
AFSQNSSLKK	HQKSHMSEKP	YECNECGKAF	RRSSNLIQHQ	RIHSGEKPYV
CSECGKAFRR	SSNLIKHHRT	HTGEKPFECG	ECGKAFSQSA	HLRKHQRVHT
GEKPYECNDC	GKPFSRVSNL	IKHHRVHTGE	KPYKCSDCGK	AFSQSSSLIQ
HRRIHTGEKP	HVCNVCGKAF	SYSSVLRKHQ	IIHTGEKPYR	CSVCGKAFSH
SSALIQHQGV	HTGDKPYACH	ECGKTFGRSS	NLILHQRVHT	GEKPYECTEC
GKTFSQSSTL	IQHQRIHNGL	KPHECNQCGK	AFNRSSNLIH	HQKVHTGEKP
YTCVECGKGF	SQSSHLIQHQ	IIHTGERPYK	CSECGKAFSQ	RSVLIQHQRI
HTGVKPYDCA	ACGKAFSQRS	KLIKHQLIHT	RE

Funkcija

Protein kodiran ovim genom sadrži C2H2 tip cinkovog prsta, pa može funkcionirati kao transkripcijski faktor. Ovaj gen se nalazi u regionu blizu ZNF7/KOX4, gena koji također kodira protein cinkovog prsta, na hromosomu 8. Identificirane su dvije alternativno prerađene varijante, koje kodiraju isti protein.^[3]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170631 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ZNF16 zinc finger protein 16".
^ "UniProt, P17020" (jezik: engleski). Pristupljeno 21. 9. 2021.

Dopunska literatura

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dreier B, Segal DJ, Barbas CF (2000). "Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains". J. Mol. Biol. 303 (4): 489–502. doi:10.1006/jmbi.2000.4133. PMID 11054286.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Rousseau-Merck MF, Duro D, Berger R, Thiesen HJ (1995). "Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22". Ann. Genet. 38 (2): 81–4. PMID 7486829.
Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170631 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: ZNF16 zinc finger protein 16".

[UniProt-4] "UniProt, P17020" (jezik: engleski). Pristupljeno 21. 9. 2021.

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