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ResearchIn-Press PreviewGeneticsOncology
Open Access | 
10.1172/JCI179617
An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling
Bolin Tao,1 Zhenning Wang,1 Xuanyi Wang,1 Aixia Song,1 Jiaxian Liu,2 Jianan Wang,1 Qin Zhang,3 Zhaolin Chen,4 Zixian Wang,5 Wenjie Xu,5 Menghong Sun,6 Yanong Wang,7 Ping Zhang,1 Tao Xu,8 Gong-Hong Wei,3 Fei Xavier Chen,1 and Mengyun Wang1
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
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1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
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1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Wang, X. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
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1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
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1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Wang, J. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Zhang, Q. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Chen, Z. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Wang, Z. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Xu, W. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Sun, M. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Wang, Y. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Zhang, P. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Xu, T. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Wei, G. in: JCI | PubMed | Google Scholar
1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
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1Cancer Institute, Department of Radiation Oncology, Fudan University, Shanghai, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China
3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medic, Biocenter Oulu, University of Oulu, Oulu, Finland
4Department of Pharmacy, The First Affiliated Hospital of USTC, Division of , University of Science and Technology of China, Hefei, China
5MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Bioc, Shanghai Medical College of Fudan University, Shanghai, China
6Department of Pathology, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
7Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
8Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
Find articles by Wang, M. in: JCI | PubMed | Google Scholar
Published February 25, 2025 - More info
Copyright © 2025, Tao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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