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ResearchIn-Press PreviewHepatologyVirology
Open Access | 
10.1172/JCI188083
PGLYRP2 drives hepatocyte-intrinsic innate immunity by trapping and clearing hepatitis B virus
Ying Li,1 Huihui Ma,1 Yongjian Zhang,2 Tinghui He,1 Binyang Li,1 Haoran Ren,1 Jia Feng,1 Jie Sheng,1 Kai Li,3 Yu Qian,1 Yunfeng Wang,4 Haoran Zhao,4 Jie He,1 Huicheng Li,5 Hongjin Wu,6 Yuanfei Yao,7 and Ming Shi1
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Li, Y. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Ma, H. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Zhang, Y. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by He, T. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Li, B. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Ren, H. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Feng, J. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Sheng, J. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Li, K. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Qian, Y. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Wang, Y. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Zhao, H. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by He, J. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Li, H. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Wu, H. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Yao, Y. in: JCI | PubMed | Google Scholar
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
2Department of Surgery Oncology, Harbin Medical University the Sixth Affiliated Hospital, Harbin, China
3School of Medicine and Health, Harbin Institute of Technology, Harbin, China
4Department of Surgery Oncology, Harbin Medical University Cancer Hospital, Harbin, China
5Biomedical Postgraduate Workstation of Heilongjiang Province, Harbin, China
6International Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai, China
7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Shi, M. in: JCI | PubMed | Google Scholar
Published February 13, 2025 - More info
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