GIPC PDZ domain containing family, member 1 (Q21496415)

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mammalian protein found in Mus musculus

RGS-GAIP-interacting protein
neurophilin1-IP
PDZ domain-containing protein GIPC1
Tax interacting protein, clone 2
SEMCAP-1
synectin
regulator of G-protein signaling 19 interacting protein 1
semaF cytoplasmic domain-associated protein 1
GAIP C-terminus-interacting protein
semaF cytoplasmic domain associated protein
Gipc1
RGS19-interacting protein 1
RGS-GAIP interacting protein GIPC

Language	Label	Description	Also known as
English	GIPC PDZ domain containing family, member 1	mammalian protein found in Mus musculus	RGS-GAIP-interacting protein neurophilin1-IP PDZ domain-containing protein GIPC1 Tax interacting protein, clone 2 SEMCAP-1 synectin regulator of G-protein signaling 19 interacting protein 1 semaF cytoplasmic domain-associated protein 1 GAIP C-terminus-interacting protein semaF cytoplasmic domain associated protein Gipc1 RGS19-interacting protein 1 RGS-GAIP interacting protein GIPC

Statements

1 reference

25 May 2022

UniProt protein ID

PDZ domain-containing protein GIPC1/2/3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0G0

PDZ superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0G0

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein homodimerization activity

determination method or standard

1 reference

14 February 2019

GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

GTPase activator activity

determination method or standard

1 reference

14 February 2019

A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

determination method or standard

1 reference

14 February 2019

Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

protein binding

determination method or standard

10 references

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

determination method or standard

1 reference

14 February 2019

GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

identical protein binding

determination method or standard

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0G0&geneProductId=UniProtKB:Q9Z0G0

determination method or standard

cadherin binding

determination method or standard

1 reference

5 June 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0G0&geneProductId=UniProtKB:Q9Z0G0

determination method or standard

synaptic vesicle

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

vesicle membrane

determination method or standard

1 reference

14 February 2019

GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

dendritic spine

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

dendritic shaft

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

glutamatergic synapse

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

biological process

protein targeting

determination method or standard

2 references

14 February 2019

GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

1 reference

14 February 2019

A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

positive regulation of transforming growth factor beta receptor signaling pathway

determination method or standard

1 reference

14 February 2019

A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

regulation of protein stability

determination method or standard

1 reference

14 February 2019

A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

regulation of synaptic plasticity

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

glutamate secretion

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

14 February 2019

A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

endothelial cell migration

determination method or standard

1 reference

14 February 2019

A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

chemical synaptic transmission

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

positive regulation of GTPase activity

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

cellular response to interleukin-7

determination method or standard

1 reference

14 February 2019

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

regulation of synaptic vesicle exocytosis

determination method or standard

1 reference

14 February 2019

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

positive regulation of melanin biosynthetic process

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0G0

determination method or standard

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0G0

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000019577

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000019577

ENSMUSP00000148824

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000148824

ENSMUSP00000148847

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000148847

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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