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Table of Contents

January 2025

Cover

Cryo-electron tomography reveals the complex flagellar motor architecture of the Lyme disease spirochete
Issue Image

Cryo-electron tomography of the Lyme disease spirochete reveals flagellar motor structure at the top panel and the cell tip at the bottom panel. Multiple flagella are located at the cell tip. Botting et al

Image Credit: Jun Liu

Pearls

The sweet side of H5N1 influenza virus infection

Marina R. Good, Devika Suja, Jenna J. Guthmiller

PLOS Pathogens: published January 23, 2025 | https://doi.org/10.1371/journal.ppat.1012847

Reviews

Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists

Sophie L. Collier, Sarah N. Farrell, Christopher D. Goodman, Geoffrey I. McFadden

PLOS Pathogens: published January 23, 2025 | https://doi.org/10.1371/journal.ppat.1012835

Malaria: Factors affecting disease severity, immune evasion mechanisms, and reversal of immune inhibition to enhance vaccine efficacy

Xin-zhuan Su, Fangzheng Xu, Rachel V. Stadler, Awet Alem Teklemichael, Jian Wu

PLOS Pathogens: published January 23, 2025 | https://doi.org/10.1371/journal.ppat.1012853

The spatial biology of HIV infection

Kevin Hu, Thomas R. O’Neil, Heeva Baharlou, Paul J. Austin, Jackson F. Karrasch, Lara Sarkawt, Yuchen Li, Kirstie M. Bertram, Anthony L. Cunningham, Ellis Patrick, Andrew N. Harman

PLOS Pathogens: published January 24, 2025 | https://doi.org/10.1371/journal.ppat.1012888

Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity

Haleema Sadia Malik, James B. Bliska

PLOS Pathogens: published January 30, 2025 | https://doi.org/10.1371/journal.ppat.1012884

Research Articles

Manganese is a potent inducer of lysosomal activity that inhibits de novo HBV infection

Lin Yu, Hao Chang, Wentao Xie, Yuan Zheng, Le Yang, Qiong Wu, Fan Bu, Yuanfei Zhu, Youhua Xie, Guoyu Pan, Ke Lan, Qiang Deng

PLOS Pathogens: published January 2, 2025 | https://doi.org/10.1371/journal.ppat.1012800

Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection

Jacques Augenstreich, Anna T. Phan, Charles N. S. Allen, Anushka Poddar, Hanzhang Chen, Lalitha Srinivasan, Volker Briken

PLOS Pathogens: published January 2, 2025 | https://doi.org/10.1371/journal.ppat.1012830

Hepatitis B virus hijacks MRE11–RAD50–NBS1 complex to form its minichromosome

Kaitao Zhao, Jingjing Wang, Zichen Wang, Mengfei Wang, Chen Li, Zaichao Xu, Qiong Zhan, Fangteng Guo, Xiaoming Cheng, Yuchen Xia

PLOS Pathogens: published January 3, 2025 | https://doi.org/10.1371/journal.ppat.1012824

Small interfering RNAs generated from the terminal panhandle structure of negative-strand RNA virus promote viral infection

Wan Zhao, Qiong Li, Mengqi Sun, Lan Luo, Xiaoming Zhang, Feng Cui

PLOS Pathogens: published January 3, 2025 | https://doi.org/10.1371/journal.ppat.1012789

USP5 inhibits anti-RNA viral innate immunity by deconjugating K48-linked unanchored and K63-linked anchored ubiquitin on IRF3

Zigang Qiao, Dapei Li, Fan Zhang, Jingfei Zhu, Siying Liu, Xue Bai, Haiping Yao, Zhengrong Chen, Yongdong Yan, Xiulong Xu, Feng Ma

PLOS Pathogens: published January 6, 2025 | https://doi.org/10.1371/journal.ppat.1012843

Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule

Tingting Wang, Huaizhi Yang, Qiushuang Sheng, Ying Ding, Jian Zhang, Feng Chen, Jianfeng Wang, Lei Song, Xuming Deng

PLOS Pathogens: published January 6, 2025 | https://doi.org/10.1371/journal.ppat.1012787

Avirulence depletion assay: Combining R gene-mediated selection with bulk sequencing for rapid avirulence gene identification in wheat powdery mildew

Lukas Kunz, Jigisha Jigisha, Fabrizio Menardo, Alexandros G. Sotiropoulos, Helen Zbinden, Shenghao Zou, Dingzhong Tang, Ralph Hückelhoven, Beat Keller, Marion C. Müller

PLOS Pathogens: published January 7, 2025 | https://doi.org/10.1371/journal.ppat.1012799

Cross-species recognition of two porcine coronaviruses to their cellular receptor aminopeptidase N of dogs and seven other species

Yuyang Tian, Junqing Sun, Xiaohan Hou, Zhimin Liu, Zeao Chen, Xiaoqian Pan, Ying Wang, Jianle Ren, Ding Zhang, Bo Yang, Longlong Si, Yuhai Bi, Kefang Liu, Guijun Shang, Wen-xia Tian, Qihui Wang, George Fu Gao, Sheng Niu

PLOS Pathogens: published January 7, 2025 | https://doi.org/10.1371/journal.ppat.1012836

SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone

Stefanos Giannakopoulos, Jin Pak, Jackson Bakse, Monika A. Ward, Vivek R. Nerurkar, Michelle D. Tallquist, Saguna Verma

PLOS Pathogens: published January 7, 2025 | https://doi.org/10.1371/journal.ppat.1012804

Key virulence factors responsible for differences in pathogenicity between clinically proven live-attenuated Japanese encephalitis vaccine SA14-14-2 and its pre-attenuated highly virulent parent SA14

Byung-Hak Song, Sang-Im Yun, Joseph L. Goldhardt, Jiyoun Kim, Young-Min Lee

PLOS Pathogens: published January 7, 2025 | https://doi.org/10.1371/journal.ppat.1012844

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via Caspase BmICE

Maoshuang Ran, Jialing Bao, Boning Li, Yulian Shi, Wenxin Yang, Xianzhi Meng, Jie Chen, Junhong Wei, Mengxian Long, Tian Li, Chunfeng Li, Guoqing Pan, Zeyang Zhou

PLOS Pathogens: published January 7, 2025 | https://doi.org/10.1371/journal.ppat.1012373

FlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi

Jack M. Botting, Md Khalesur Rahman, Hui Xu, Jian Yue, Wangbiao Guo, Joshua T. Del Mundo, Michal Hammel, Md A. Motaleb, Jun Liu

PLOS Pathogens: published January 8, 2025 | https://doi.org/10.1371/journal.ppat.1012812

An interferon-stimulated long non-coding RNA USP30-AS1 as an immune modulator in influenza A virus infection

Yi Cao, Alex W. H. Chin, Haogao Gu, Mengting Li, Yuner Gu, Sylvia P. N. Lau, Kenrie P. Y. Hui, Michael C. W. Chan, Leo L. M. Poon

PLOS Pathogens: published January 8, 2025 | https://doi.org/10.1371/journal.ppat.1012854

Enhancing vaccine half-life as a novel strategy for improving immune response durability of subunit vaccines

Zhaoling Shen, Cheng Li, Wenping Song, Litong Liu, Yu Kong, Ailing Huang, Qingui Bao, Tianlei Ying, Yanling Wu

PLOS Pathogens: published January 8, 2025 | https://doi.org/10.1371/journal.ppat.1012845

Widespread release of translational repression across Plasmodium’s host-to-vector transmission event

Kelly T. Rios, James P. McGee, Aswathy Sebastian, Sanjaya Aththawala Gedara, Robert L. Moritz, Marina Feric, Sabrina Absalon, Kristian E. Swearingen, Scott E. Lindner

PLOS Pathogens: published January 8, 2025 | https://doi.org/10.1371/journal.ppat.1012823

A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis

Erika Kroll, Carlos Bayon, Jason Rudd, Victoria J. Armer, Anjana Magaji-Umashankar, Ryan Ames, Martin Urban, Neil A. Brown, Kim Hammond-Kosack

PLOS Pathogens: published January 9, 2025 | https://doi.org/10.1371/journal.ppat.1012769

Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

Min Zhang, Karim Mouzannar, Zhensheng Zhang, Yuji Teraoka, Jason Piotrowski, Yuji Ishida, Chise Tateno-Mukaidani, Takeshi Saito, Hiromi Abe-Chayama, Kazuaki Chayama, T. Jake Liang

PLOS Pathogens: published January 9, 2025 | https://doi.org/10.1371/journal.ppat.1012803

Breaking a barrier: In trans vlsE recombination and genetic manipulation of the native vlsE gene of the Lyme disease pathogen

Preeti Singh, Troy Bankhead

PLOS Pathogens: published January 10, 2025 | https://doi.org/10.1371/journal.ppat.1012871

A Helicobacter pylori flagellar motor accessory is needed to maintain the barrier function of the outer membrane during flagellar rotation

Kyle Rosinke, Shoichi Tachiyama, Jan Mrásek, Jun Liu, Timothy R. Hoover

PLOS Pathogens: published January 10, 2025 | https://doi.org/10.1371/journal.ppat.1012860

SLC35A2 gene product modulates paramyxovirus fusion events during infection

Yanling Yang, Yuchen Wang, Danielle E. Campbell, Heng-Wei Lee, Wandy Beatty, Leran Wang, Megan Baldridge, Carolina B. López

PLOS Pathogens: published January 10, 2025 | https://doi.org/10.1371/journal.ppat.1012531

Transcriptomic HIV-1 reservoir profiling reveals a role for mitochondrial functionality in HIV-1 latency

Shirley Man, Jade Jansen, Stefanie Kroeze, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra

PLOS Pathogens: published January 10, 2025 | https://doi.org/10.1371/journal.ppat.1012822

SIV Env RhmAbs + N-803 at ART initiation prolongs viral decay without disrupting reservoir establishment in SIV-infected infant macaques

Omotayo Farinre, Tzoalli Anaya, Alexis C. King, Kedan Endrias, Anne H. Hébert, Alison L. Hill, Sherrie Jean, Jennifer S. Wood, Stephanie Ehnert, Shan Liang, Gregory M. Laird, Rosemarie D. Mason, Mario Roederer, Jeffrey T. Safrit, Maud Mavigner, Ann Chahroudi

PLOS Pathogens: published January 10, 2025 | https://doi.org/10.1371/journal.ppat.1012863

Genomic exploration of the journey of Plasmodium vivax in Latin America

Margaux J. M. Lefebvre, Fanny Degrugillier, Céline Arnathau, Gustavo A. Fontecha, Oscar Noya, Sandrine Houzé, Carlo Severini, Bruno Pradines, Antoine Berry, Jean-François Trape, Fabian E. Sáenz, Franck Prugnolle, Michael C. Fontaine, Virginie Rougeron

PLOS Pathogens: published January 13, 2025 | https://doi.org/10.1371/journal.ppat.1012811

Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation

Zhe Sun, Zicheng Ma, Wandi Cao, Chenlong Jiang, Lei Guo, Kesen Liu, Yanni Gao, Juan Bai, Jiang Pi, Ping Jiang, Xing Liu

PLOS Pathogens: published January 13, 2025 | https://doi.org/10.1371/journal.ppat.1012872

Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype

Florence E. McLean, Brian R. Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I. Abdi, Rivka Lim, Thomas D. Otto, Ashfaq Ghumra, J. Alexandra Rowe

PLOS Pathogens: published January 13, 2025 | https://doi.org/10.1371/journal.ppat.1012434

Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4′-Fluorouridine

Peiqi Yin, Elizabeth B. Sobolik, Nicholas A. May, Sainan Wang, Atef Fayed, Dariia Vyshenska, Adam M. Drobish, M. Guston Parks, Laura Sandra Lello, Andres Merits, Thomas E. Morrison, Alexander L. Greninger, Margaret Kielian

PLOS Pathogens: published January 13, 2025 | https://doi.org/10.1371/journal.ppat.1012859

Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion

Dominique Dorin-Semblat, Jean-Philippe Semblat, Romain Hamelin, Anand Srivastava, Marilou Tetard, Graziella Matesic, Christian Doerig, Benoit Gamain

PLOS Pathogens: published January 13, 2025 | https://doi.org/10.1371/journal.ppat.1012861

The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole

Marie Seveno, Manon N. Loubens, Laurence Berry, Arnault Graindorge, Maryse Lebrun, Catherine Lavazec, Mauld H. Lamarque

PLOS Pathogens: published January 14, 2025 | https://doi.org/10.1371/journal.ppat.1012455

Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin

J. B. Collins, Clayton M. Dilks, Steffen R. Hahnel, Briana Rodriguez, Bennett W. Fox, Elizabeth Redman, Jingfang Yu, Brittany Cooke, Kateryna Sihuta, Mostafa Zamanian, Peter J. Roy, Frank C. Schroeder, John S. Gilleard, Erik C. Andersen

PLOS Pathogens: published January 14, 2025 | https://doi.org/10.1371/journal.ppat.1012602

MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as a model of βHPV in typical epidermodysplasia verruciformis

Margaret Wong, Hsin-Fang Tu, Ssu-Hsieh Tseng, Rebecca Mellinger-Pilgrim, Simon Best, Hua-Ling Tsai, Deyin Xing, Chien-fu Hung, Paul F. Lambert, Richard B. S. Roden

PLOS Pathogens: published January 15, 2025 | https://doi.org/10.1371/journal.ppat.1012837

Kaposi’s sarcoma-associated herpesvirus (KSHV) gB dictates a low-pH endocytotic entry pathway as revealed by a dual-fluorescent virus system and a rhesus monkey rhadinovirus expressing KSHV gB

Shanchuan Liu, Sarah Schlagowski, Anna K. Großkopf, Natalia Khizanishvili, Xiaoliang Yang, Scott W. Wong, Elina M. Guzmán, Marija Backovic, Stefano Scribano, Arne Cordsmeier, Armin Ensser, Alexander S. Hahn

PLOS Pathogens: published January 16, 2025 | https://doi.org/10.1371/journal.ppat.1012846

Deficient neutrophil responses early in influenza infection promote viral replication and pulmonary inflammation

Henry H. Gong, Matthew J. Worley, Kyle A. Carver, Caleb J. Godin, Jane C. Deng

PLOS Pathogens: published January 17, 2025 | https://doi.org/10.1371/journal.ppat.1012449

Insights into the origin, hybridisation and adaptation of Candida metapsilosis hybrid pathogens

Valentina del Olmo, Álvaro Redondo-Río, Alicia Benavente García, Savitree Limtong, Ester Saus, Toni Gabaldón

PLOS Pathogens: published January 17, 2025 | https://doi.org/10.1371/journal.ppat.1012864

KSHV hijacks the antiviral kinase IKKε to initiate lytic replication

Xiaoqian Wang, Zhenshan Liu, Xue Xu, Xin Wang, Zizhen Ming, Chengrong Liu, Hang Gao, Tingting Li, Qiming Liang

PLOS Pathogens: published January 17, 2025 | https://doi.org/10.1371/journal.ppat.1012856

RING finger protein 5 is a key anti-FMDV host factor through inhibition of virion assembly

Wei Zhang, Weiwei Li, Yang Yang, Weijun Cao, Wenhua Shao, Mengyao Huang, Jiali Wang, Zhitong Chen, Jiantao Cai, Hongyi Liu, Xiaoyi Zhao, Xingyan Dong, Tingting Zhou, Hong Tian, Zixiang Zhu, Fan Yang, Haixue Zheng

PLOS Pathogens: published January 17, 2025 | https://doi.org/10.1371/journal.ppat.1012848

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection

Nicholas Rohlfes, Rajalingam Radhakrishnan, Parmit K. Singh, Gregory J. Bedwell, Alan N. Engelman, Adarsh Dharan, Edward M. Campbell

PLOS Pathogens: published January 17, 2025 | https://doi.org/10.1371/journal.ppat.1012354

Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance

Magdalena Widziolek, Anna Mieszkowska, Magdalena Marcinkowska, Bartlomiej Salamaga, Justyna Folkert, Krzysztof Rakus, Magdalena Chadzinska, Jan Potempa, Graham P. Stafford, Tomasz K. Prajsnar, Craig Murdoch

PLOS Pathogens: published January 21, 2025 | https://doi.org/10.1371/journal.ppat.1012821

Assessing bnAb potency in the context of HIV-1 envelope conformational plasticity

Caio Foulkes, Nikolas Friedrich, Branislav Ivan, Emanuel Stiegeler, Carsten Magnus, Daniel Schmidt, Umut Karakus, Jacqueline Weber, Huldrych F. Günthard, Chloé Pasin, Peter Rusert, Alexandra Trkola

PLOS Pathogens: published January 21, 2025 | https://doi.org/10.1371/journal.ppat.1012825

A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs

Samuel M. Goodfellow, Robert A. Nofchissey, Chunyan Ye, Jaecy K. Banther-McConnell, Thanchira Suriyamongkol, Joseph A. Cook, Jonathan L. Dunnum, Ivana Mali, Steven B. Bradfute

PLOS Pathogens: published January 21, 2025 | https://doi.org/10.1371/journal.ppat.1012849

Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread

Alexander Tishchenko, Nicolás Romero, Cliff Van Waesberghe, Jonas L. Delva, Oliver Vickman, Gregory A. Smith, Thomas C. Mettenleiter, Walter Fuchs, Barbara G. Klupp, Herman W. Favoreel

PLOS Pathogens: published January 21, 2025 | https://doi.org/10.1371/journal.ppat.1012895

The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling

Yongkui Li, Moran Li, Heng Xiao, Feng Liao, Miaomiao Shen, Weiwei Ge, Junxian Ou, Yuqing Liu, Lumiao Chen, Yue Zhao, Pin Wan, Jinbiao Liu, Jun Chen, Xianwu Lan, Shaorong Wu, Qiang Ding, Geng Li, Qiwei Zhang, Pan Pan

PLOS Pathogens: published January 22, 2025 | https://doi.org/10.1371/journal.ppat.1012886

Administration of antigenically distinct influenza viral particle combinations as an influenza vaccine strategy

Xinyu Zhu, Zhaochen Luo, Rebecca A. Leonard, Cait E. Hamele, Rachel L. Spreng, Nicholas S. Heaton

PLOS Pathogens: published January 22, 2025 | https://doi.org/10.1371/journal.ppat.1012878

A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies

Melanie Rissmann, Danny Noack, Thomas M. Spliethof, Vincent P. Vaes, Rianne Stam, Peter van Run, Jordan J. Clark, Georges M. G. M. Verjans, Bart L. Haagmans, Florian Krammer, Marion P. G. Koopmans, Judith M. A. van den Brand, Barry Rockx

PLOS Pathogens: published January 22, 2025 | https://doi.org/10.1371/journal.ppat.1012875

Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions

Miguel Ángel Pérez-Castro, Hasier Eraña, Enric Vidal, Jorge M. Charco, Nuria L. Lorenzo, Nuno Gonçalves-Anjo, Josu Galarza-Ahumada, Carlos M. Díaz-Domínguez, Patricia Piñeiro, Ezequiel González-Miranda, Samanta Giler, Glenn Telling, Manuel A. Sánchez-Martín, Joseba Garrido, Mariví Geijo, Jesús R. Requena, Joaquín Castilla

PLOS Pathogens: published January 22, 2025 | https://doi.org/10.1371/journal.ppat.1012890

Spatiotemporal profile of an optimal host response to virus infection in the primate central nervous system

Olga A. Maximova, Sarah L. Anzick, Daniel E. Sturdevant, Richard S. Bennett, Lawrence J. Faucette, Marisa St. Claire, Stephen S. Whitehead, Kishore Kanakabandi, Zong-mei Sheng, Yongli Xiao, John C. Kash, Jeffery K. Taubenberger, Craig Martens, Jeffrey I. Cohen

PLOS Pathogens: published January 22, 2025 | https://doi.org/10.1371/journal.ppat.1012530

A bacterial type III effector hijacks plant ubiquitin proteases to evade degradation

Wenjia Yu, Meng Li, Wenjun Wang, Haiyan Zhuang, Jiamin Luo, Yuying Sang, Cecile Segonzac, Alberto P. Macho

PLOS Pathogens: published January 22, 2025 | https://doi.org/10.1371/journal.ppat.1012882

Atypical memory B cells from natural malaria infection produced broadly neutralizing antibodies against Plasmodium vivax variants

Piyawan Kochayoo, Saya Moriyama, Ryutaro Kotaki, Pongsakorn Thawornpan, Chayapat Malee, Chaniya Leepiyasakulchai, Francis Babila Ntumngia, John H. Adams, Yoshimasa Takahashi, Patchanee Chootong

PLOS Pathogens: published January 23, 2025 | https://doi.org/10.1371/journal.ppat.1012866

Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques

Christopher T. Edwards, Kirti A. Karunakaran, Elijah Garcia, Nathan Beutler, Matthew Gagne, Nadia Golden, Hadj Aoued, Kathryn L. Pellegrini, Matthew R. Burnett, Christopher Cole Honeycutt, Stacey A. Lapp, Thang Ton, Mark C. Lin, Amanda Metz, Andrei Bombin, Kelly Goff, Sarah E. Scheuermann, Amelia Wilkes, Jennifer S. Wood, Stephanie Ehnert, Stacey Weissman, Elizabeth H. Curran, Melissa Roy, Evan Dessasau, Mirko Paiardini, Amit A. Upadhyay, Ian N. Moore, Nicholas J. Maness, Daniel C. Douek, Anne Piantadosi, Raiees Andrabi, Thomas R. Rogers, Dennis R. Burton, Steven E. Bosinger

PLOS Pathogens: published January 23, 2025 | https://doi.org/10.1371/journal.ppat.1012456

Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies

Peter R. McIlroy, Le Thanh Mai Pham, Thomas Sheffield, Maxwell A. Stefan, Christine E. Thatcher, James Jaryenneh, Jennifer L. Schwedler, Anupama Sinha, Christopher A. Sumner, Iris K. A. Jones, Stephen Won, Ryan C. Bruneau, Dina R. Weilhammer, Zhuoming Liu, Sean Whelan, Oscar A. Negrete, Kenneth L. Sale, Brooke Harmon

PLOS Pathogens: published January 23, 2025 | https://doi.org/10.1371/journal.ppat.1012903

Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021–2024

Andrew D. Marques, Matthew Hogenauer, Natalie Bauer, Michelle Gibison, Beatrice DeMarco, Scott Sherrill-Mix, Carter Merenstein, Ronald G. Collman, Roderick B. Gagne, Frederic D. Bushman

PLOS Pathogens: published January 24, 2025 | https://doi.org/10.1371/journal.ppat.1012883

Diverse autoinhibitory mechanisms of FIIND-containing proteins: Insight into regulation of NLRP1 and CARD8 inflammasome

Jingfan Zhou, Chengrong Liu, Xin Wang, Zhenshan Liu, Zizhen Ming, Yonggang Wang, Chunxia Wang, Qiming Liang

PLOS Pathogens: published January 24, 2025 | https://doi.org/10.1371/journal.ppat.1012877

Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt

Alyssa Hubal, Anusha Vendhoti, Charles N. Shaffer, Sarah Vos, Yalitza Lopez Corcino, Carlos S. Subauste

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012907

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir

Szu-Wei Huang, Lorenzo Briganti, Arun S. Annamalai, Juliet Greenwood, Nikoloz Shkriabai, Reed Haney, Michael L. Armstrong, Michael F. Wempe, Satya Prakash Singh, Ashwanth C. Francis, Alan N. Engelman, Mamuka Kvaratskhelia

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012862

Suppressing Tymovirus replication in plants using a variant of ubiquitin

Anuradha De Silva, Kihun Kim, John Weiland, Jihyun Hwang, Jacky Chung, Higor S. Pereira, Trushar R. Patel, Joan Teyra, Ankoor Patel, Mohammed M. Mira, Mazdak Khajehpour, Melvin Bolton, Claudio Stasolla, Sachdev S. Sidhu, Brian L. Mark

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012899

The transcriptional and translational landscape of HCoV-OC43 infection

Stefan Bresson, Emanuela Sani, Alicja Armatowska, Charles Dixon, David Tollervey

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012831

Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection

Zhihao Chen, Qiyuan Jin, Jinqi Zhong, Zonggang Xie, Qi Chen, Liubing Li, Jijie Li, Chenhao Zhao, Junfeng Wang, Xiaoying Tang, Mingxiao Han, Ru Li, Ziyuan Li, Zelei Tong, Min Wang, Hong Du, Haifang Zhang

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012896

A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection

Emily A. Fitzmeyer, Taru S. Dutt, Silvain Pinaud, Barb Graham, Emily N. Gallichotte, Jessica L. Hill, Corey L. Campbell, Hunter Ogg, Virginia Howick, Mara K. N. Lawniczak, Erin Osborne Nishimura, Sarah Hélène Merkling, Marcela Henao-Tamayo, Gregory D. Ebel

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012855

Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions

Karen Campos-León, Jack Ferguson, Thomas Günther, C. David Wood, Steven W. Wingett, Selin Pekel, Christy S. Varghese, Leanne S. Jones, Joanne D. Stockton, Csilla Várnai, Michelle J. West, Andrew Beggs, Adam Grundhoff, Boris Noyvert, Sally Roberts, Joanna L. Parish

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012506

Hatching of whipworm eggs induced by bacterial contact is serine-protease dependent

David Goulding, Charlotte Tolley, Tapoka T. Mkandawire, Stephen R. Doyle, Emily Hart, Paul M. Airs, Richard K. Grencis, Matthew Berriman, María A. Duque-Correa

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012502

M-Sec promotes the accumulation of intracellular HTLV-1 Gag puncta and the incorporation of Env into viral particles

Masateru Hiyoshi, Youssef M. Eltalkhawy, Randa A. Abdelnaser, Akira Ono, Kazuaki Monde, Yosuke Maeda, Reem M. Mahmoud, Naofumi Takahashi, Yasuyoshi Hatayama, Akihide Ryo, Satoshi Nozuma, Hiroshi Takashima, Ryuji Kubota, Shinya Suzu

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012919

PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation

Lujie Zhang, Yanni Gao, Haoran Zhou, Xiao Liang, Xiaolin Jiang, Wenqin Gong, Yangyang Sun, Desheng Zhang, Xianwei Wang, Hans Nauwynck, Juan Bai, Ping Jiang

PLOS Pathogens: published January 27, 2025 | https://doi.org/10.1371/journal.ppat.1012915

Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing

Tiana M. Scott, Lydia M. Arnold, Jordan A. Powers, Delaney A. McCann, Ana B. Rowe, Devin E. Christensen, Miguel J. Pereira, Wen Zhou, Rachel M. Torrez, Janet H. Iwasa, Philip J. Kranzusch, Wesley I. Sundquist, Jarrod S. Johnson

PLOS Pathogens: published January 28, 2025 | https://doi.org/10.1371/journal.ppat.1012206

Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infection

Santiago Boccardo, Constanza Rodriguez, Camila M. S. Gimenez, Cintia L. Araujo Furlan, Carolina P. Abrate, Laura Almada, Manuel A. Saldivia Concepción, Peter Skewes-Cox, Srinivasa P. S. Rao, Jorge H. Mukdsi, Carolina L. Montes, Adriana Gruppi, Eva V. Acosta Rodríguez

PLOS Pathogens: published January 30, 2025 | https://doi.org/10.1371/journal.ppat.1012906

Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein

Qian Qiu, Zihan He, Jing Liu, Huijun Xu, Jinyu Wang, Nannan Liu, Ning Kang, Shaokun Pan, Weien Yu, Zixiang Gao, Shimei Zhang, Yang Yang, Qiang Deng, Youhua Xie, Jiming Zhang, Zhongliang Shen

PLOS Pathogens: published January 30, 2025 | https://doi.org/10.1371/journal.ppat.1012897

Extended receptor repertoire of an adenovirus associated with human obesity

A. Manuel Liaci, Naresh Chandra, Sharvani Munender Vodnala, Michael Strebl, Pravin Kumar, Vanessa Pfenning, Paul Bachmann, Rémi Caraballo, Wengang Chai, Emil Johansson, Mikael Elofsson, Ten Feizi, Yan Liu, Thilo Stehle, Niklas Arnberg

PLOS Pathogens: published January 30, 2025 | https://doi.org/10.1371/journal.ppat.1012892

Pair combinations of human monoclonal antibodies fully protected mice against bunyavirus SFTSV lethal challenge

Bang Li, Xiang-rong Qin, Jia-chen Qu, Guan-du Wu, Wen-kang Zhang, Ze-zheng Jiang, Pan-pan Liu, Ze-min Li, Tian-mei Yu, Chuan-min Zhou, Yong-jun Jiao, Xue-jie Yu

PLOS Pathogens: published January 31, 2025 | https://doi.org/10.1371/journal.ppat.1012889

CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth

Gina L. Griffith, Kawthar Machmach, Ningbo Jian, Dohoon Kim, Margaret C. Costanzo, Matthew Creegan, Isabella Swafford, Gautam Kundu, Lauren Yum, Jessica S. Bolton, Lauren Smith, Bonnie M. Slike, Elke S. Bergmann-Leitner, Rasmi Thomas, Nelson L. Michael, Julie A. Ake, Leigh Anne Eller, Merlin L. Robb, Samantha M. Townsley, Shelly J. Krebs, Dominic Paquin-Proulx, for the RV217 Study Group

PLOS Pathogens: published January 31, 2025 | https://doi.org/10.1371/journal.ppat.1012916

Baculoviruses manipulate host lipid metabolism via adipokinetic hormone signaling to induce climbing behavior

Lin Zhu, Yuqing Xie, Chenxi Liu, Jie Cheng, Zhongjian Shen, Xiaoming Liu, Limei Cai, Xinyuan Ning, Songdou Zhang, Zhen Li, Qiuying Huang, Xiaoxia Liu

PLOS Pathogens: published January 31, 2025 | https://doi.org/10.1371/journal.ppat.1012932

Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes

Erick O. Awuoche, Gretchen Smallenberger, Daniel L. Bruzzese, Alessandra Orfano, Brian L. Weiss, Serap Aksoy

PLOS Pathogens: published January 31, 2025 | https://doi.org/10.1371/journal.ppat.1012692

Oxidative stress-driven enhanced iron production and scavenging through Ferroportin reorientation worsens anemia in antimony-resistant Leishmania donovani infection

Souradeepa Ghosh, Krishna Vamshi Chigicherla, Shirin Dasgupta, Yasuyuki Goto, Budhaditya Mukherjee

PLOS Pathogens: published January 31, 2025 | https://doi.org/10.1371/journal.ppat.1012858