CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma (Q92424232)

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29 April 2020

title

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma (English)

1 reference

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29 April 2020

main subject

hepatocellular carcinoma

1 reference

0 references

0 references

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8

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29 April 2020

author name string

Adi Zheng

1

1 reference

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29 April 2020

Nadja Chevalier

2

1 reference

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29 April 2020

Margot Calderoni

3

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29 April 2020

Gilles Dubuis

4

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29 April 2020

Olivier Dormond

5

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29 April 2020

Panos G Ziros

6

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29 April 2020

Gerasimos P Sykiotis

7

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29 April 2020

publication date

17 December 2019

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29 April 2020

1 reference

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29 April 2020

volume

10

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issue

66

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29 April 2020

page(s)

7058-7070

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Regorafenib: A Review in Hepatocellular Carcinoma

29 April 2020

cites work

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Genome-wide CRISPR screen reveals SGOL1 as a druggable target of sorafenib-treated hepatocellular carcinoma

11 February 2021

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11 February 2021

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TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma.

11 February 2021

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11 February 2021

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Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

11 February 2021

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KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

11 February 2021

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Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.

11 February 2021

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The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner

11 February 2021

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Hepatocellular carcinoma: Review of disease and tumor biomarkers

11 February 2021

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Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

11 February 2021

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

11 February 2021

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Structural basis of Keap1 interactions with Nrf2.

11 February 2021

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11 February 2021

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MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

11 February 2021

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Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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The emerging role of the Nrf2-Keap1 signaling pathway in cancer

11 February 2021

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Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma

11 February 2021

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11 February 2021

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Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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Sorafenib in advanced hepatocellular carcinoma

11 February 2021

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11 February 2021

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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

11 February 2021

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11 February 2021

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11 February 2021

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

11 February 2021

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Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions

11 February 2021

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11 February 2021

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10.18632/ONCOTARGET.27361

11 February 2021

Identifiers

DOI

1 reference

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29 April 2020

1 reference

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29 April 2020

PubMed publication ID

31903165

1 reference