Immune inhibitor receptor LAIR1 in gliomas and fibroblast–secreted collagen

In this episode, Shashwat Tripathi and Hinda Najem discuss how, using scRNA-seq, their analysis shows that CAFs, specifically the immune modulatory subtype, are increased in frequency as a function of glioma grade. Notably, collagen is a key ligand for the immune checkpoint LAIR-1. The study also characterizes which collagens are present in gliomas and their anatomical locations within the tumor microenvironment that can serve as a reference for the scientific community.

Pulmonary artery endothelial function and hypertension are impacted by RAB7 deficiency

In this episode, Laszlo Farkas explains that the results of this study indicate that reduced endothelial expression of endolysosomal RAB7 causes dysregulation of autophagy, mitochondrial dysfunction and endothelial senescence, and induces spontaneous PH.

Microglial activation and tau transmission aggravated by Galectin-3 in tauopathy

In this episode, Yijuang Chern and Jian Jing Siew discuss the novel role of Gal3 in the regulation of extracellular vesicles, promotion of pathogenic tau fibrillation, and microglial activation.

Numerous shared tumor antigens in breast cancer immunopeptidomes

In this episode, Eralda Kina and Claude Perreault explain how using proteogenomics, their manuscript identifies tumor-specific antigens in primary human breast cancers. These antigens are more numerous in triple-negative tumors and represent attractive targets for immunotherapy.

Suppression by regulatory T cells and Foxp3-mediated blockage of ryanodine receptor 2

In this episode, Xiaobo Wang, Shuang Geng, and Junchen Meng explain how this work reestablished the suppressive functions in Tconvs absence of Foxp3 indistinguishable from Tregs by simply blocking RyR2 expression.